iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000120833.13	ENST00000340600.6	ENSP00000339428.2
ENSG00000120833.13	ENST00000548537.1	ENSP00000448709.1
ENSG00000120833.13	ENST00000551883.1	ENSP00000474805.1
ENSG00000120833.13	ENST00000549510.1	ENSP00000474888.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	miRWalk	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	17997974; 17363902

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-15	58.5	153	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ +SLqhLCRl+I++c+g      i++LPLP +LkdYL+++++q
   Q: 153  TKPLYTSAPSLQHLCRLTINKCTGA-----IWGLPLPTRLKDYLEEYKFQ 197
           678999*******************.....8***************9886 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.

Protein Sequence
(Fasta)

MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCCATAG CCGCGGCCTC AACTAAAAGT GGCCATTGAC CTTTCAAGCT TTCGAGCAGT 60
GATGCAATAG AATAGTATTT CAAAGAAAAA TGCTTATCGA AATTTTGGAT CCGGTTTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005131--F:growth hormone receptor binding
GO:0005159--F:insulin-like growth factor receptor binding
GO:0008269--F:JAK pathway signal transduction adaptor activity
GO:0004860--F:protein kinase inhibitor activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0032870--P:cellular response to hormone stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0009966--P:regulation of signal transduction
GO:0032355--P:response to estradiol

KEGG

hsa:8835

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	95.96	3.00e-105	373.00
IUUC-Apl-003484	Anas platyrhynchos	80.39	6.00e-73	266.00
IUUC-Aca-004253	Anolis carolinensis	71.95	5.00e-72	263.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	3.10e-02	33.10
IUUC-Ame-011267	Astyanax mexicanus	62.87	2.00e-59	221.00
IUUC-Bta-013183	Bos taurus	94.44	8.00e-99	352.00
IUUC-Bra-017915	Brassica rapa	33.90	5.60e-02	32.00
IUUC-Cja-018862	Callithrix jacchus	98.99	5.00e-104	369.00
IUUC-Cfa-020226	Canis familiaris	94.42	2.00e-96	344.00
IUUC-Cpo-022414	Cavia porcellus	95.96	4.00e-105	373.00
IUUC-Csa-023758	Chlorocebus sabaeus	98.48	4.00e-108	383.00
IUUC-Cho-024471	Choloepus hoffmanni	86.84	4.00e-72	263.00
IUUC-Dre-028288	Danio rerio	56.48	4.00e-63	234.00
IUUC-Dno-029036	Dasypus novemcinctus	96.46	9.00e-107	379.00
IUUC-Dor-030447	Dipodomys ordii	98.68	2.00e-87	314.00
IUUC-Ete-033023	Echinops telfairi	93.94	3.00e-110	390.00
IUUC-Fca-036469	Felis catus	96.97	5.00e-101	359.00
IUUC-Fal-036642	Ficedula albicollis	73.37	6.00e-71	259.00
IUUC-Gmo-039331	Gadus morhua	61.54	3.00e-35	140.00
IUUC-Gga-040809	Gallus gallus	77.36	3.00e-73	266.00
IUUC-Gac-041398	Gasterosteus aculeatus	55.61	3.00e-58	218.00
IUUC-Ggo-045341	Gorilla gorilla	99.49	4.00e-104	370.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	82.21	5.00e-93	333.00
IUUC-Lch-050160	Latimeria chalumnae	62.59	2.00e-49	188.00
IUUC-Loc-051825	Lepisosteus oculatus	64.46	2.00e-61	228.00
IUUC-Laf-053560	Loxodonta africana	94.95	2.00e-98	351.00
IUUC-Mcc-055890	Macaca mulatta	98.48	4.00e-103	366.00
IUUC-Meu-056218	Macropus eugenii	80.30	5.00e-96	343.00
IUUC-Mga-059755	Meleagris gallopavo	79.61	2.00e-71	261.00
IUUC-Mmr-061387	Microcebus murinus	96.97	1.00e-105	375.00
IUUC-Mdo-062383	Monodelphis domestica	81.31	4.00e-96	343.00
IUUC-Mmu-063443	Mus musculus	93.43	7.00e-102	362.00
IUUC-Mpu-066459	Mustela putorius furo	95.45	2.00e-99	354.00
IUUC-Mlu-068040	Myotis lucifugus	96.97	3.00e-107	380.00
IUUC-Nle-069016	Nomascus leucogenys	93.43	4.00e-100	357.00
IUUC-Opr-071087	Ochotona princeps	88.38	9.00e-103	365.00
IUUC-Ont-072340	Oreochromis niloticus	57.29	4.00e-60	223.00
IUUC-Oan-073443	Ornithorhynchus anatinus	78.28	4.00e-90	323.00
IUUC-Ocu-074539	Oryctolagus cuniculus	94.92	2.00e-99	355.00
IUUC-Ogu-078951	Oryza glumaepatula	27.03	5.00e-02	32.70
IUUC-Oin-079476	Oryza indica	27.03	4.60e-02	32.70
IUUC-Oni-082613	Oryza nivara	27.03	4.60e-02	32.70
IUUC-Oru-085265	Oryza rufipogon	27.03	4.90e-02	32.70
IUUC-Ola-087004	Oryzias latipes	60.13	3.00e-55	207.00
IUUC-Oga-088438	Otolemur garnettii	96.46	4.00e-106	377.00
IUUC-Oar-089932	Ovis aries	94.44	2.00e-98	351.00
IUUC-Ptr-091037	Pan troglodytes	99.49	4.00e-104	370.00
IUUC-Pan-092767	Papio anubis	98.48	4.00e-103	366.00
IUUC-Psi-093099	Pelodiscus sinensis	77.36	4.00e-74	270.00
IUUC-Pma-094671	Petromyzon marinus	48.37	5.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	50.52	4.00e-55	207.00
IUUC-Pab-098319	Pongo abelii	98.99	2.00e-109	387.00
IUUC-Pca-101117	Procavia capensis	93.43	6.00e-100	356.00
IUUC-Pva-102117	Pteropus vampyrus	94.95	1.00e-97	348.00
IUUC-Rno-105913	Rattus norvegicus	92.93	2.00e-101	361.00
IUUC-Sha-106500	Sarcophilus harrisii	81.22	2.00e-94	337.00
IUUC-Ssc-115252	Sus scrofa	95.96	3.00e-105	374.00
IUUC-Tgu-117524	Taeniopygia guttata	76.10	2.00e-70	257.00
IUUC-Tsy-119335	Tarsius syrichta	95.36	1.00e-85	307.00
IUUC-Tni-120263	Tetraodon nigroviridis	54.26	3.00e-56	211.00
IUUC-Tca-121866	Theobroma cacao	42.86	1.40e-02	34.30
IUUC-Tbe-127915	Tupaia belangeri	94.44	5.00e-96	343.00
IUUC-Ttr-128372	Tursiops truncatus	95.45	1.00e-104	372.00
IUUC-Vpa-130422	Vicugna pacos	98.68	3.00e-87	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence