iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045001

UUCD1 version

UUC-GoG-00590

Ensembl Protein ID

ENSGGOP00000014635.2

UniProt Accession

G3RG92; G3RG92_GORGO

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014988.2	ENSGGOT00000015048.2	ENSGGOP00000014635.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.70e-135	450.2	501	833

Active Site

Position(s)	Description	Evidence
802	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 501  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 588
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 589  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 674
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 675  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 762
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 763  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 833
           *********************************************************************96 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MATASPRSDT SDNHSGRLQL QVTVERVKEQ LKLSLENKNG IAQTGELTVV LDGLVIEQEN 60
ITNCSSSPTI EIQENGDALH ENGEPSARTT ARLAVEGTNG IDNHVPTSTL VQNSCCSYVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CTTCACCAAG GTCTGATACT AGTGATAACC ACAGTGGAAG GTTGCAGTTA 60
CAGGTAACTG GTAAGTTATT TTTATATTTA ATATGGTGAT TCCCTGATGA ACTTTTCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	94.20	0.00e+00	1571.00
IUUC-Apl-003310	Anas platyrhynchos	82.64	0.00e+00	1365.00
IUUC-Aca-005388	Anolis carolinensis	80.10	0.00e+00	1304.00
IUUC-Bta-012857	Bos taurus	93.59	0.00e+00	1534.00
IUUC-Cja-019448	Callithrix jacchus	97.53	0.00e+00	1637.00
IUUC-Cfa-020728	Canis familiaris	95.31	0.00e+00	1575.00
IUUC-Cpo-021635	Cavia porcellus	88.83	0.00e+00	1485.00
IUUC-Csa-023805	Chlorocebus sabaeus	98.68	0.00e+00	1387.00
IUUC-Cho-024943	Choloepus hoffmanni	84.50	0.00e+00	1216.00
IUUC-Cin-025212	Ciona intestinalis	73.70	0.00e+00	883.00
IUUC-Csv-026256	Ciona savignyi	72.66	0.00e+00	877.00
IUUC-Dre-028245	Danio rerio	91.07	0.00e+00	1118.00
IUUC-Dno-029618	Dasypus novemcinctus	95.19	0.00e+00	1582.00
IUUC-Dor-030665	Dipodomys ordii	82.36	0.00e+00	1085.00
IUUC-Dme-032041	Drosophila melanogaster	71.02	0.00e+00	875.00
IUUC-Ete-032779	Echinops telfairi	94.89	0.00e+00	1119.00
IUUC-Eca-033313	Equus caballus	91.62	0.00e+00	1490.00
IUUC-Eeu-035259	Erinaceus europaeus	83.85	0.00e+00	1377.00
IUUC-Fca-035420	Felis catus	93.46	0.00e+00	1561.00
IUUC-Fal-037335	Ficedula albicollis	82.66	0.00e+00	1357.00
IUUC-Gmo-039172	Gadus morhua	86.44	0.00e+00	1019.00
IUUC-Gga-040246	Gallus gallus	82.66	0.00e+00	1354.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.11	0.00e+00	1127.00
IUUC-Hsa-046544	Homo sapiens	99.63	0.00e+00	1669.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	91.43	0.00e+00	1562.00
IUUC-Lch-050398	Latimeria chalumnae	78.06	0.00e+00	1245.00
IUUC-Loc-052116	Lepisosteus oculatus	75.58	0.00e+00	1214.00
IUUC-Laf-053551	Loxodonta africana	91.89	0.00e+00	1518.00
IUUC-Meu-056455	Macropus eugenii	67.16	0.00e+00	822.00
IUUC-Mga-059986	Meleagris gallopavo	82.25	0.00e+00	1355.00
IUUC-Mmr-060945	Microcebus murinus	92.73	0.00e+00	1542.00
IUUC-Mdo-063024	Monodelphis domestica	82.00	0.00e+00	1310.00
IUUC-Mmu-063202	Mus musculus	90.51	0.00e+00	1456.00
IUUC-Mpu-065773	Mustela putorius furo	94.46	0.00e+00	1556.00
IUUC-Mlu-067373	Myotis lucifugus	66.06	0.00e+00	943.00
IUUC-Nle-069188	Nomascus leucogenys	98.89	0.00e+00	1656.00
IUUC-Opr-070965	Ochotona princeps	88.29	0.00e+00	1445.00
IUUC-Oan-073497	Ornithorhynchus anatinus	85.22	0.00e+00	1367.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.16	0.00e+00	1456.00
IUUC-Ola-087438	Oryzias latipes	89.11	0.00e+00	1133.00
IUUC-Oga-087922	Otolemur garnettii	94.46	0.00e+00	1563.00
IUUC-Oar-089429	Ovis aries	93.09	0.00e+00	1518.00
IUUC-Ptr-090484	Pan troglodytes	99.51	0.00e+00	1668.00
IUUC-Pan-092117	Papio anubis	98.77	0.00e+00	1657.00
IUUC-Psi-093338	Pelodiscus sinensis	82.88	0.00e+00	1365.00
IUUC-Pma-094279	Petromyzon marinus	74.91	0.00e+00	846.00
IUUC-Pfo-096171	Poecilia formosa	92.47	0.00e+00	1135.00
IUUC-Pab-098654	Pongo abelii	84.53	0.00e+00	1378.00
IUUC-Pva-102811	Pteropus vampyrus	87.66	0.00e+00	1316.00
IUUC-Rno-106125	Rattus norvegicus	90.26	0.00e+00	1463.00
IUUC-Sha-107243	Sarcophilus harrisii	84.46	0.00e+00	1372.00
IUUC-Sre-114929	Sporisorium reilianum	45.76	4.00e-152	531.00
IUUC-Ssc-115368	Sus scrofa	93.00	0.00e+00	1534.00
IUUC-Tgu-117079	Taeniopygia guttata	82.13	0.00e+00	1338.00
IUUC-Tru-118062	Takifugu rubripes	71.51	0.00e+00	1182.00
IUUC-Tsy-119507	Tarsius syrichta	90.01	0.00e+00	1483.00
IUUC-Tni-120151	Tetraodon nigroviridis	70.25	0.00e+00	1152.00
IUUC-Ttr-129260	Tursiops truncatus	82.86	0.00e+00	1328.00
IUUC-Uma-129332	Ustilago maydis	45.93	6.00e-145	508.00
IUUC-Xtr-132877	Xenopus tropicalis	68.49	0.00e+00	1056.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence