iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020806

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03005649

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000012582.3	ENSCAFT00000020013.3	ENSCAFP00000018565.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.10e-38	130.8	410	718

Active Site

Position(s)	Description	Evidence
688	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v+E+   g +++G+++efl ll+++l+n+     +++ + +++l+ n+ +      +++l++ +G++l+++l++g + + ++
   Q: 410  HTIEVAYVNENdnfGREHPGSKQEFLCLLMQHLENSP----VFEGSLSKNLSLNSRAL-----EENLYYEAGKILAISLVHGGPSPGFF 489
           57899999998888**********************9....46777888888888885.....579*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + ++  ++  ++ +  +dl++      ++e++++  + g+ +i    ++k++  ++++ y
   Q: 490  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQMIIRV--NTATNVADLNSV-----VNECYNYLELIGCLRIITSLSDKYRLAEDILVY 568
           ***********8...9**********99988887774..555555777776.....7889999999*********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerk....af 264
           ++ ++++  +e+f++G++++  le+++ + e   ++++++ e+++++ l++   ++  +t ++ +   Fw+ + +++++ + +    ++
   Q: 569  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFYSIFCHKPENLSAKVLSD--LFTV-CTLSDVQALGFWNNYlQAVEDGKSAitmeDL 654
           *************************************************99..7777.6666666669998663666666654222267 PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           L F+Tg++++P++Gf++ + ++ +++      ++P  n+C n+L LP  +++++++e++ +Ai++t ++e
   Q: 655  LIFATGCNSIPPAGFKPTP-SIECLHM-----DFPIGNKCNNCLALPITNTYQEFQENMDFAIRNTLRLE 718
           77****************9.9999999.....********************************987665 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MPWVLAVRRR RGGEDVTTYK IKMNENKPGA SQNLACVFCR KNDDCPNKYG EKKTNEKWNI 60
TVHYYCLLMS SGIWQRGKEE EGVYGFLIED IRKEVNRASK LKCSICKKTG ASIGCVAPRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGTTACC TTTGTTGAAA ATCAAATGAC TGGAAAATAT TTTTCTTGGC TTTCTAGTTT 60
TGTTCCATTG GTCTATGTGG AATTGTGTAT ACTAATATAC TTTGGAAAAC TACATAAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

cfa:490639

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	94.48	0.00e+00	1410.00
IUUC-Apl-003763	Anas platyrhynchos	60.03	0.00e+00	860.00
IUUC-Aca-004328	Anolis carolinensis	60.81	0.00e+00	869.00
IUUC-Ame-011288	Astyanax mexicanus	40.79	3.00e-166	578.00
IUUC-Bta-012496	Bos taurus	87.20	0.00e+00	1307.00
IUUC-Cja-019756	Callithrix jacchus	88.49	0.00e+00	1323.00
IUUC-Cpo-022519	Cavia porcellus	87.11	0.00e+00	1286.00
IUUC-Csa-023957	Chlorocebus sabaeus	89.52	0.00e+00	1343.00
IUUC-Cho-024375	Choloepus hoffmanni	83.12	0.00e+00	1192.00
IUUC-Cin-025325	Ciona intestinalis	42.23	4.00e-68	251.00
IUUC-Csv-026262	Ciona savignyi	42.33	3.00e-68	252.00
IUUC-Dre-027829	Danio rerio	41.20	2.00e-155	543.00
IUUC-Dno-029362	Dasypus novemcinctus	88.28	0.00e+00	1308.00
IUUC-Dor-030710	Dipodomys ordii	83.00	0.00e+00	1256.00
IUUC-Dme-031692	Drosophila melanogaster	34.53	3.00e-42	166.00
IUUC-Ete-032282	Echinops telfairi	79.72	0.00e+00	1146.00
IUUC-Eca-033963	Equus caballus	91.78	0.00e+00	1373.00
IUUC-Eeu-035029	Erinaceus europaeus	86.24	0.00e+00	1295.00
IUUC-Fca-036229	Felis catus	95.18	0.00e+00	1423.00
IUUC-Fal-037015	Ficedula albicollis	58.17	0.00e+00	871.00
IUUC-Gmo-039715	Gadus morhua	40.43	1.00e-79	289.00
IUUC-Gga-040298	Gallus gallus	58.32	0.00e+00	895.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.20	2.00e-143	503.00
IUUC-Ggo-045456	Gorilla gorilla	89.24	0.00e+00	1336.00
IUUC-Hsa-046297	Homo sapiens	89.39	0.00e+00	1345.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.08	0.00e+00	920.00
IUUC-Lch-050287	Latimeria chalumnae	66.14	9.00e-106	377.00
IUUC-Loc-052839	Lepisosteus oculatus	55.05	2.00e-32	130.00
IUUC-Laf-053581	Loxodonta africana	87.72	0.00e+00	1292.00
IUUC-Mcc-055615	Macaca mulatta	89.53	0.00e+00	1347.00
IUUC-Meu-056753	Macropus eugenii	48.88	3.00e-130	459.00
IUUC-Mga-059902	Meleagris gallopavo	58.50	0.00e+00	897.00
IUUC-Mmr-061522	Microcebus murinus	90.81	0.00e+00	1358.00
IUUC-Mdo-063022	Monodelphis domestica	64.78	0.00e+00	897.00
IUUC-Mmu-063609	Mus musculus	76.28	0.00e+00	1170.00
IUUC-Mpu-066656	Mustela putorius furo	92.00	0.00e+00	1414.00
IUUC-Mlu-067011	Myotis lucifugus	89.12	0.00e+00	1330.00
IUUC-Nle-069949	Nomascus leucogenys	89.09	0.00e+00	1338.00
IUUC-Opr-071224	Ochotona princeps	83.46	1.00e-130	460.00
IUUC-Ont-072174	Oreochromis niloticus	38.20	8.00e-139	487.00
IUUC-Oan-072712	Ornithorhynchus anatinus	67.43	0.00e+00	978.00
IUUC-Ocu-073776	Oryctolagus cuniculus	89.24	0.00e+00	1330.00
IUUC-Ola-087247	Oryzias latipes	37.68	2.00e-131	463.00
IUUC-Oga-088094	Otolemur garnettii	86.36	0.00e+00	1219.00
IUUC-Oar-090248	Ovis aries	86.03	0.00e+00	1310.00
IUUC-Ptr-090634	Pan troglodytes	89.24	0.00e+00	1340.00
IUUC-Pan-092876	Papio anubis	89.66	0.00e+00	1346.00
IUUC-Psi-093580	Pelodiscus sinensis	60.55	0.00e+00	880.00
IUUC-Pma-094295	Petromyzon marinus	53.36	1.00e-73	269.00
IUUC-Pfo-096351	Poecilia formosa	38.02	4.00e-148	518.00
IUUC-Pab-097596	Pongo abelii	89.94	0.00e+00	1348.00
IUUC-Pca-100309	Procavia capensis	81.16	0.00e+00	1201.00
IUUC-Pva-102526	Pteropus vampyrus	92.47	0.00e+00	857.00
IUUC-Rno-105432	Rattus norvegicus	80.20	0.00e+00	1207.00
IUUC-Sha-107089	Sarcophilus harrisii	64.97	0.00e+00	1014.00
IUUC-Sar-113667	Sorex araneus	67.90	0.00e+00	978.00
IUUC-Ssc-116200	Sus scrofa	90.79	0.00e+00	1357.00
IUUC-Tgu-116467	Taeniopygia guttata	57.36	0.00e+00	856.00
IUUC-Tru-117690	Takifugu rubripes	39.03	9.00e-155	540.00
IUUC-Tsy-119481	Tarsius syrichta	87.00	0.00e+00	912.00
IUUC-Tni-119669	Tetraodon nigroviridis	38.47	5.00e-136	478.00
IUUC-Tbe-127241	Tupaia belangeri	81.25	0.00e+00	1167.00
IUUC-Ttr-129057	Tursiops truncatus	81.73	0.00e+00	1172.00
IUUC-Vpa-130685	Vicugna pacos	88.48	0.00e+00	1295.00
IUUC-Xtr-132555	Xenopus tropicalis	52.31	0.00e+00	750.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence