iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003501

Ensembl Protein ID

ENSAPLP00000001811.1

UniProt Accession

U3I3J0; U3I3J0_ANAPL

Genbank Protein ID

ENSAPLP00000001811

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01059572

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000002302.1	ENSAPLT00000002387.1	ENSAPLP00000001811.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.10e-38	132.5	93	263
UBD/ZnF/ZnF_A20	1.80e-23	81.9	759	790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak 76
           l++lkt+gDGnCL++A+sq+++g+ d d+ l++ l++aLre  ++++    q+e+ + +ef+e++        e+e+e++ ++ +pe+ 
   Q: 93   LVPLKTNGDGNCLMHAASQYMWGIEDIDLvLRKTLFSALREIDTRNFklrwQREAIKSQEFVETGlrydtrnwEEEWEYLIEMTSPETS 181
           5789***********************************************************************************99 PP
   S: 77   g..........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           g          eeihif+La+iL+rpiiv++++ ++s          +vgg++lpll+p+e+ +++pivL+Y+++H+ +Lv+
   Q: 182  GarnrlpynalEEIHIFILANILRRPIIVLADKVVRSlesgssfaplNVGGVYLPLLWPAEEcYRYPIVLGYDNMHFTPLVT 263
           8899****************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrr 33
           +k++C++ +C++YGn ++ngyC++Cy++++ +
   Q: 759  PKQRCRApACDHYGNTKCNGYCNECYQFKQIY 790
           79***************************977 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MAGQHVLPQA LYQSNMLKAV KIRERTPEDL VKPPNGIIHH FRTMHRYTIE MFRMCQFCPQ 60
FREMLQKALT DQATQTSLER QRKLNWCMEV RKLVPLKTNG DGNCLMHAAS QYMWGIEDID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGCC AACATGTCCT TCCTCAGGCT TTGTATCAGA GCAATATGCT GAAAGCTGTG 60
AAGATCAGAG AGAGAACACC TGAAGATCTG GTCAAACCCC CCAATGGAAT AATTCACCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	65.62	0.00e+00	1066.00
IUUC-Aca-004245	Anolis carolinensis	68.94	0.00e+00	1146.00
IUUC-Ame-011789	Astyanax mexicanus	47.17	0.00e+00	710.00
IUUC-Bta-012664	Bos taurus	64.69	0.00e+00	1030.00
IUUC-Cja-019895	Callithrix jacchus	66.46	0.00e+00	1066.00
IUUC-Cfa-020754	Canis familiaris	66.00	0.00e+00	1071.00
IUUC-Cpo-021780	Cavia porcellus	64.99	0.00e+00	1038.00
IUUC-Csa-023568	Chlorocebus sabaeus	66.58	0.00e+00	1076.00
IUUC-Cho-024300	Choloepus hoffmanni	76.70	2.00e-159	555.00
IUUC-Dre-028577	Danio rerio	48.57	0.00e+00	687.00
IUUC-Dno-029382	Dasypus novemcinctus	64.90	0.00e+00	1036.00
IUUC-Dor-030874	Dipodomys ordii	63.43	0.00e+00	1008.00
IUUC-Ete-032721	Echinops telfairi	75.42	0.00e+00	666.00
IUUC-Eca-033596	Equus caballus	66.54	0.00e+00	1071.00
IUUC-Eeu-035159	Erinaceus europaeus	62.28	0.00e+00	788.00
IUUC-Fca-035847	Felis catus	66.42	0.00e+00	1075.00
IUUC-Fal-036681	Ficedula albicollis	84.65	0.00e+00	1381.00
IUUC-Gmo-038521	Gadus morhua	60.44	2.00e-150	526.00
IUUC-Gga-040975	Gallus gallus	88.05	0.00e+00	1445.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.53	2.00e-156	545.00
IUUC-Ggo-045258	Gorilla gorilla	66.20	0.00e+00	1071.00
IUUC-Hsa-046071	Homo sapiens	66.33	0.00e+00	1072.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	66.08	0.00e+00	1059.00
IUUC-Lch-050326	Latimeria chalumnae	57.02	0.00e+00	904.00
IUUC-Loc-051945	Lepisosteus oculatus	48.03	0.00e+00	628.00
IUUC-Laf-053722	Loxodonta africana	67.47	0.00e+00	1087.00
IUUC-Mcc-055503	Macaca mulatta	66.20	0.00e+00	1071.00
IUUC-Meu-056481	Macropus eugenii	62.24	0.00e+00	989.00
IUUC-Mga-059690	Meleagris gallopavo	85.88	0.00e+00	1332.00
IUUC-Mmr-061233	Microcebus murinus	65.83	0.00e+00	1048.00
IUUC-Mdo-062446	Monodelphis domestica	66.62	0.00e+00	1094.00
IUUC-Mmu-063436	Mus musculus	64.32	0.00e+00	1033.00
IUUC-Mpu-066808	Mustela putorius furo	66.67	0.00e+00	1078.00
IUUC-Mlu-067339	Myotis lucifugus	66.50	0.00e+00	1074.00
IUUC-Nle-069888	Nomascus leucogenys	66.08	0.00e+00	1067.00
IUUC-Opr-070303	Ochotona princeps	66.42	0.00e+00	1061.00
IUUC-Ont-072283	Oreochromis niloticus	59.33	5.00e-152	531.00
IUUC-Oan-072925	Ornithorhynchus anatinus	67.29	0.00e+00	1098.00
IUUC-Ocu-073889	Oryctolagus cuniculus	66.33	0.00e+00	1048.00
IUUC-Ola-087417	Oryzias latipes	60.29	6.00e-154	537.00
IUUC-Oga-088708	Otolemur garnettii	65.83	0.00e+00	1024.00
IUUC-Oar-089271	Ovis aries	65.07	0.00e+00	1040.00
IUUC-Ptr-091296	Pan troglodytes	66.33	0.00e+00	1071.00
IUUC-Pan-092474	Papio anubis	66.33	0.00e+00	1072.00
IUUC-Psi-093447	Pelodiscus sinensis	75.79	0.00e+00	1238.00
IUUC-Pfo-096511	Poecilia formosa	44.46	0.00e+00	647.00
IUUC-Pab-098700	Pongo abelii	66.54	0.00e+00	1071.00
IUUC-Pca-100246	Procavia capensis	62.65	0.00e+00	722.00
IUUC-Pva-102606	Pteropus vampyrus	62.53	1.00e-141	496.00
IUUC-Rno-105818	Rattus norvegicus	65.49	0.00e+00	1056.00
IUUC-Sha-106559	Sarcophilus harrisii	65.88	0.00e+00	1075.00
IUUC-Sar-113454	Sorex araneus	76.15	1.00e-156	546.00
IUUC-Ssc-116064	Sus scrofa	65.70	0.00e+00	1040.00
IUUC-Tgu-117212	Taeniopygia guttata	85.73	0.00e+00	1398.00
IUUC-Tru-118230	Takifugu rubripes	61.65	1.00e-156	546.00
IUUC-Tsy-119066	Tarsius syrichta	64.02	0.00e+00	1031.00
IUUC-Tni-119825	Tetraodon nigroviridis	47.87	0.00e+00	684.00
IUUC-Tur-126383	Triticum urartu	52.00	1.50e-01	27.30
IUUC-Tbe-127601	Tupaia belangeri	76.15	8.00e-157	546.00
IUUC-Ttr-128930	Tursiops truncatus	63.81	0.00e+00	1027.00
IUUC-Vpa-130450	Vicugna pacos	74.50	0.00e+00	638.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence