iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132390

Ensembl Protein ID

ENSXETP00000008404.3

UniProt Accession

Q0IJ33; TM129_XENTR

Genbank Protein ID

AAI21211.1

Protein Name

E3 ubiquitin-protein ligase TM129; RING-type E3 ubiquitin transferase TM129

Genbank Nucleotide ID

BC121210

Gene Name

tmem129

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000003875.3	ENSXETT00000008404.3	ENSXETP00000008404.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	74.86	2.00e-167	586.00	IUUC-Hsa-046951

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2.

Protein Sequence
(Fasta)

MESPEVTFTL AYVVFSVCFV FTPNEFHSAG ITVQNLLSGW LGSEDVAFVH YHIRRSTATL 60
LTHSLLPMGY FIGMCFAAPE KELYNVYKAA DGWKVFVLIT VLLPVTTSIL AFYWSQKRWG 120

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Nucleotide Sequence
(Fasta)

CGGAAGTGCA TGCCCTGCGC TTTGCTGGCA TGGAGAGCCC GGAGGTTACT TTTACACTTG 60
CCTATGTGGT GTTTTCCGTG TGTTTCGTAT TCACCCCCAA TGAGTTCCAC TCGGCAGGGA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018801--Tmpp129

Pfam

PF10272--Tmpp129

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0016740--F:transferase activity
GO:0016567--P:protein ubiquitination
GO:0006986--P:response to unfolded protein

KEGG

xtr:548871

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001914	Ailuropoda melanoleuca	75.07	1.00e-169	588.00
IUUC-Apl-003347	Anas platyrhynchos	79.61	2.00e-172	597.00
IUUC-Ame-010846	Astyanax mexicanus	67.51	6.00e-156	543.00
IUUC-Bta-012669	Bos taurus	72.65	8.00e-165	572.00
IUUC-Cel-018636	Caenorhabditis elegans	25.59	8.00e-18	84.70
IUUC-Cja-019250	Callithrix jacchus	70.99	2.00e-159	554.00
IUUC-Cfa-020230	Canis familiaris	74.86	1.00e-169	588.00
IUUC-Cpo-022023	Cavia porcellus	75.97	5.00e-173	600.00
IUUC-Csa-023823	Chlorocebus sabaeus	74.59	3.00e-167	580.00
IUUC-Cin-025745	Ciona intestinalis	42.15	7.00e-92	330.00
IUUC-Csv-025856	Ciona savignyi	40.16	2.00e-88	318.00
IUUC-Dre-028722	Danio rerio	71.87	2.00e-162	564.00
IUUC-Dno-029635	Dasypus novemcinctus	72.73	7.00e-129	452.00
IUUC-Dor-030657	Dipodomys ordii	74.86	5.00e-167	580.00
IUUC-Dse-031278	Dothistroma septosporum	36.67	8.60e-02	31.60
IUUC-Dme-031679	Drosophila melanogaster	32.47	3.00e-62	232.00
IUUC-Ete-032708	Echinops telfairi	75.22	2.00e-101	361.00
IUUC-Eca-033244	Equus caballus	73.47	1.00e-134	471.00
IUUC-Fca-035762	Felis catus	74.86	1.00e-168	585.00
IUUC-Fal-036939	Ficedula albicollis	80.66	1.00e-179	622.00
IUUC-Gmo-039282	Gadus morhua	65.07	1.00e-104	372.00
IUUC-Gga-040148	Gallus gallus	80.11	2.00e-178	617.00
IUUC-Gac-042319	Gasterosteus aculeatus	65.12	1.00e-148	518.00
IUUC-Hsa-046951	Homo sapiens	74.86	7.00e-169	586.00
IUUC-Itr-048030	Ictidomys tridecemlineatus	75.69	5.00e-170	590.00
IUUC-Lch-050659	Latimeria chalumnae	81.06	0.00e+00	642.00
IUUC-Loc-052168	Lepisosteus oculatus	76.80	2.00e-177	614.00
IUUC-Laf-054003	Loxodonta africana	75.69	3.00e-171	594.00
IUUC-Mcc-055211	Macaca mulatta	74.03	2.00e-166	577.00
IUUC-Mga-059834	Meleagris gallopavo	79.87	1.00e-144	505.00
IUUC-Mdo-062514	Monodelphis domestica	81.99	0.00e+00	639.00
IUUC-Mmu-063651	Mus musculus	75.69	3.00e-165	574.00
IUUC-Mpu-066843	Mustela putorius furo	75.69	4.00e-172	597.00
IUUC-Mlu-067390	Myotis lucifugus	64.95	3.00e-78	284.00
IUUC-Nle-069501	Nomascus leucogenys	73.00	4.00e-136	477.00
IUUC-Ont-071406	Oreochromis niloticus	65.40	5.00e-145	506.00
IUUC-Oan-073199	Ornithorhynchus anatinus	75.69	3.00e-154	537.00
IUUC-Ola-086495	Oryzias latipes	62.74	5.00e-142	497.00
IUUC-Oga-087914	Otolemur garnettii	75.14	1.00e-168	585.00
IUUC-Oar-089585	Ovis aries	57.43	3.00e-96	344.00
IUUC-Ptr-090660	Pan troglodytes	73.47	3.00e-133	467.00
IUUC-Pan-092206	Papio anubis	74.59	2.00e-167	581.00
IUUC-Psi-093829	Pelodiscus sinensis	81.97	0.00e+00	635.00
IUUC-Pma-094399	Petromyzon marinus	65.38	3.00e-148	517.00
IUUC-Pfo-096826	Poecilia formosa	62.19	5.00e-143	500.00
IUUC-Pab-097827	Pongo abelii	74.59	4.00e-169	587.00
IUUC-Pca-100182	Procavia capensis	75.97	1.00e-165	575.00
IUUC-Pva-103236	Pteropus vampyrus	73.21	6.00e-44	170.00
IUUC-Rno-105429	Rattus norvegicus	75.14	1.00e-164	572.00
IUUC-Sha-107104	Sarcophilus harrisii	79.46	1.00e-146	511.00
IUUC-Ssc-116316	Sus scrofa	74.03	1.00e-155	541.00
IUUC-Tgu-116563	Taeniopygia guttata	79.83	4.00e-178	616.00
IUUC-Tbe-127698	Tupaia belangeri	75.09	6.00e-136	476.00
IUUC-Ttr-128759	Tursiops truncatus	72.93	9.00e-162	562.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence