iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000016512.1	ENSONIT00000020810.1	ENSONIP00000020791.1
ENSONIG00000016512.1	ENSONIT00000020811.1	ENSONIP00000020792.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-114	382.9	569	898

Active Site

Position(s)	Description	Evidence
869	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+    + re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al++++l+++ 
   Q: 569  EKLKQGIAVRFHGEEGMYK-HLVREWFDILSNEIINPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALYHRQLVNIY 654
           78999**********9988.8*********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 655  FTRSFYKHILGIPVNYQDVSSIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGTSILVTQDNKAEYVQLVTEL 740
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf++ ip +l++lF+e elell++G++eidv+d+ ++t y++gy +++++iqwFw+v+ ++++eer  +LqFvT
   Q: 741  RMTRAIQPQINAFLQGFHTFIPASLIQLFDEYELELLLSGMPEIDVQDWCRNTDYTSGYDAQEQVIQWFWDVVTGLTQEERVLLLQFVT 829
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+l+     ++f+i     + + lP+s+TC+n+LkLPeY+ske+l+++Ll+A + +  g
   Q: 830  GSSRVPHGGFAYLMggsgLQKFTIAAvPYTSNLLPTSSTCINMLKLPEYPSKEVLRDRLLVALHCGsYG 898
           ******************88899998677779*******************************986555 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MERAMEQLNV QLSRLTRSLR RARTVELPED NETAVYTLMP MVMADQHRSV SELLLNSKFD 60
VNYAFGRVKR SLLHIAANCG SVECLVLLLK RGANPNYQDI SGSTPVHLAA RNGQKKCMGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACGTCATC ACAACAGGAA GTGTGAACAT GGCAATAACA GCCTCATAAA TCATTGTGTC 60
CAGCACAGAA ACGAGTTGCT GTCCATCCTG GCTAATGGAA GACAGCAGAT AACAACACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	84.47	0.00e+00	1607.00
IUUC-Apl-003400	Anas platyrhynchos	79.10	0.00e+00	1044.00
IUUC-Aca-005375	Anolis carolinensis	84.00	0.00e+00	1603.00
IUUC-Ame-011847	Astyanax mexicanus	89.27	0.00e+00	1706.00
IUUC-Bta-012831	Bos taurus	84.70	0.00e+00	1570.00
IUUC-Cja-019160	Callithrix jacchus	84.66	0.00e+00	1610.00
IUUC-Cfa-020346	Canis familiaris	84.75	0.00e+00	1615.00
IUUC-Cpo-021766	Cavia porcellus	84.31	0.00e+00	1603.00
IUUC-Csa-023768	Chlorocebus sabaeus	84.53	0.00e+00	1610.00
IUUC-Cho-024688	Choloepus hoffmanni	78.91	0.00e+00	986.00
IUUC-Cin-025417	Ciona intestinalis	48.25	2.00e-136	480.00
IUUC-Csv-025993	Ciona savignyi	44.06	0.00e+00	759.00
IUUC-Dre-027819	Danio rerio	89.71	0.00e+00	1689.00
IUUC-Dno-029027	Dasypus novemcinctus	83.87	0.00e+00	1596.00
IUUC-Dor-030327	Dipodomys ordii	77.59	0.00e+00	1402.00
IUUC-Ete-032966	Echinops telfairi	78.56	0.00e+00	1477.00
IUUC-Eca-034339	Equus caballus	84.42	0.00e+00	1607.00
IUUC-Eeu-034544	Erinaceus europaeus	58.00	2.00e-155	543.00
IUUC-Fca-035617	Felis catus	82.24	0.00e+00	1113.00
IUUC-Fal-036687	Ficedula albicollis	82.33	0.00e+00	1615.00
IUUC-Gmo-039508	Gadus morhua	82.02	0.00e+00	1214.00
IUUC-Gga-040845	Gallus gallus	82.77	0.00e+00	1628.00
IUUC-Gac-041894	Gasterosteus aculeatus	92.93	0.00e+00	1701.00
IUUC-Ggo-044465	Gorilla gorilla	81.22	0.00e+00	1537.00
IUUC-Hsa-045731	Homo sapiens	84.64	0.00e+00	1613.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	85.14	0.00e+00	1615.00
IUUC-Lch-050436	Latimeria chalumnae	86.74	0.00e+00	1653.00
IUUC-Loc-052287	Lepisosteus oculatus	86.11	0.00e+00	1699.00
IUUC-Laf-053846	Loxodonta africana	84.87	0.00e+00	1620.00
IUUC-Mcc-055845	Macaca mulatta	84.64	0.00e+00	1613.00
IUUC-Meu-056060	Macropus eugenii	88.82	0.00e+00	637.00
IUUC-Mga-059935	Meleagris gallopavo	84.96	0.00e+00	1617.00
IUUC-Mmr-060960	Microcebus murinus	84.86	0.00e+00	1618.00
IUUC-Mdo-061851	Monodelphis domestica	81.83	0.00e+00	1598.00
IUUC-Mmu-063657	Mus musculus	84.31	0.00e+00	1606.00
IUUC-Mpu-066161	Mustela putorius furo	89.70	0.00e+00	756.00
IUUC-Mlu-067354	Myotis lucifugus	83.43	0.00e+00	1535.00
IUUC-Nle-069112	Nomascus leucogenys	84.42	0.00e+00	1612.00
IUUC-Opr-070686	Ochotona princeps	79.95	0.00e+00	736.00
IUUC-Oan-073194	Ornithorhynchus anatinus	84.77	0.00e+00	1555.00
IUUC-Ocu-074397	Oryctolagus cuniculus	77.81	0.00e+00	1423.00
IUUC-Ola-086777	Oryzias latipes	85.35	0.00e+00	1637.00
IUUC-Oga-088684	Otolemur garnettii	84.87	0.00e+00	1611.00
IUUC-Oar-089428	Ovis aries	83.87	0.00e+00	1575.00
IUUC-Ptr-090529	Pan troglodytes	84.53	0.00e+00	1610.00
IUUC-Pan-091702	Papio anubis	84.75	0.00e+00	1614.00
IUUC-Psi-093969	Pelodiscus sinensis	82.04	0.00e+00	1549.00
IUUC-Pfo-097364	Poecilia formosa	92.47	0.00e+00	1703.00
IUUC-Pab-098574	Pongo abelii	84.64	0.00e+00	1613.00
IUUC-Pca-100525	Procavia capensis	77.62	5.00e-161	561.00
IUUC-Pva-102365	Pteropus vampyrus	74.51	0.00e+00	1365.00
IUUC-Rno-105153	Rattus norvegicus	84.10	0.00e+00	1607.00
IUUC-Sha-107319	Sarcophilus harrisii	82.21	0.00e+00	1600.00
IUUC-Sar-113449	Sorex araneus	64.95	2.00e-135	476.00
IUUC-Ssc-115865	Sus scrofa	84.31	0.00e+00	1605.00
IUUC-Tgu-117225	Taeniopygia guttata	82.65	0.00e+00	1623.00
IUUC-Tru-118026	Takifugu rubripes	90.17	0.00e+00	1695.00
IUUC-Tsy-119407	Tarsius syrichta	73.42	0.00e+00	1338.00
IUUC-Tni-120234	Tetraodon nigroviridis	91.61	0.00e+00	1348.00
IUUC-Tbe-127708	Tupaia belangeri	71.63	0.00e+00	704.00
IUUC-Ttr-128667	Tursiops truncatus	84.20	0.00e+00	1605.00
IUUC-Vpa-130200	Vicugna pacos	84.23	0.00e+00	1553.00
IUUC-Xtr-132176	Xenopus tropicalis	82.37	0.00e+00	1615.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence