iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037199

Ensembl Protein ID

ENSFALP00000010022.1

UniProt Accession

U3K4R8; U3K4R8_FICAL

Genbank Protein ID

ENSFALP00000010022

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTO01020440

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000009614.1	ENSFALT00000010062.1	ENSFALP00000010022.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-59	201.9	191	720

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenp..............kepkgellkslqklfeelwkskkkavsp 70
           +G++NlgNtC++N+v+Q L++++ l el+ e           + +                 ++ g+l++++  +++++ +  k+  sp
   Q: 191  KGINNLGNTCFFNAVMQNLAQTHVLNELMYEikekgT-----KLK-IchtsdsqldplvvnLSSPGPLTSAMFLFLHSMREAGKGPLSP 273
           59*****************************554431.....222.22334456666666677888*********************** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksq 153
           + l+++l+++a++f+g++qqD+qE+l++lld+++ e +k+ ++ + +++++ ++++ de      + +  +  + ++i+++F g+l+s+
   Q: 274  KVLFSQLCQKAPRFKGFQQQDSQELLHYLLDAIRIEETKRIQTGILKAFNNPTTKTADEetrrkvKAYGREGVKMNFIDRIFVGELTST 362
           ***********************************9999788888888777777777773333335555555555************** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
           ++c+ec+n+s+ +epf+dlslp+ +++  k+                                                          
   Q: 363  VMCEECENISTVKEPFIDLSLPIIEERVAKPVplgrtgksksvqeadlgqyncssigtlnnqpkivkkhtltkdknqlnherrlarkas 451
           ***************************98777********************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  skeeernpvimqekakklelegssgvpyskdpsaeaavngsqtegsekeasrsessfdadseasesesaskqttlsppssvsgahvnhl 540
           ***************************************************************************************** PP
   S: 186  ...............................................................................slqdcLesft 195
                                                                                          s+q+cL +ft
   Q: 541  npktphkpsdsneemissaisklsfcdpvkedkksscgdpalglsnnsmfsvgksslsqnpqnafqtlsqsyitsskecSVQSCLYQFT 629
           ***************************************************************************************** PP
   S: 196  keeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           + e l g+nk+ ce+c+++++                   a+k+l ++++P +LilhLkRf  ++++ s +k+n++v+fpl Ldl+pfc
   Q: 630  SVELLMGNNKLLCESCTERKQkyqkktnstekktegvytnARKQLLISSVPAILILHLKRF--HQAGLSLRKVNRHVDFPLILDLAPFC 716
           *****************88888888889999999999999*********************..9999********************** PP
   S: 266  tspe 269
           + ++
   Q: 717  AASC 720
           9865 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MRVKDPSRTN PEKSKRSKRP NRPQDEDSSD DISGLTCQHV SQAVDVHHVK RAVAQSVWSI 60
CAECLKERRM SDGEPVAPSD IWLCLKCGSQ GCSKNSEGQH SLKHFQTART EPHCIVINLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAGCAACAG ATGCGGGTGA AAGATCCATC AAGAACCAAC CCTGAGAAGT CAAAGAGAAG 60
CAAAAGGCCT AACAGGCCAC AGGATGAGGA CTCTTCAGAT GATATTTCAG GTAAGTACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	61.50	0.00e+00	773.00
IUUC-Apl-003512	Anas platyrhynchos	91.15	0.00e+00	1305.00
IUUC-Aca-004284	Anolis carolinensis	71.25	0.00e+00	984.00
IUUC-Aly-006422	Arabidopsis lyrata	28.24	4.00e-30	127.00
IUUC-Ath-006732	Arabidopsis thaliana	29.87	7.00e-34	139.00
IUUC-Bta-012880	Bos taurus	68.35	0.00e+00	926.00
IUUC-Cja-019144	Callithrix jacchus	67.12	0.00e+00	941.00
IUUC-Cfa-020971	Canis familiaris	68.41	0.00e+00	627.00
IUUC-Cpo-022497	Cavia porcellus	72.11	0.00e+00	629.00
IUUC-Csa-023910	Chlorocebus sabaeus	66.89	0.00e+00	924.00
IUUC-Cho-024358	Choloepus hoffmanni	51.14	6.00e-91	327.00
IUUC-Dre-028106	Danio rerio	52.07	0.00e+00	733.00
IUUC-Dno-029456	Dasypus novemcinctus	63.94	5.00e-132	464.00
IUUC-Dor-030438	Dipodomys ordii	54.08	0.00e+00	633.00
IUUC-Ete-032736	Echinops telfairi	54.07	0.00e+00	660.00
IUUC-Eca-034211	Equus caballus	67.35	0.00e+00	936.00
IUUC-Eeu-034797	Erinaceus europaeus	76.57	6.00e-79	288.00
IUUC-Fca-035947	Felis catus	65.95	0.00e+00	805.00
IUUC-Gmo-039228	Gadus morhua	65.57	1.00e-150	526.00
IUUC-Gga-040823	Gallus gallus	87.32	0.00e+00	669.00
IUUC-Gac-042406	Gasterosteus aculeatus	55.91	0.00e+00	697.00
IUUC-Ggo-045402	Gorilla gorilla	66.94	0.00e+00	929.00
IUUC-Hsa-046430	Homo sapiens	66.62	0.00e+00	931.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	64.42	3.00e-123	435.00
IUUC-Lch-049547	Latimeria chalumnae	63.32	0.00e+00	846.00
IUUC-Loc-052842	Lepisosteus oculatus	61.87	0.00e+00	852.00
IUUC-Laf-053988	Loxodonta africana	68.08	0.00e+00	947.00
IUUC-Mcc-055491	Macaca mulatta	64.34	0.00e+00	882.00
IUUC-Meu-056256	Macropus eugenii	66.82	2.00e-147	516.00
IUUC-Mtr-057945	Medicago truncatula	32.72	1.00e-35	145.00
IUUC-Mga-059833	Meleagris gallopavo	81.90	0.00e+00	681.00
IUUC-Mmr-060952	Microcebus murinus	66.53	0.00e+00	909.00
IUUC-Mdo-062642	Monodelphis domestica	73.87	0.00e+00	1012.00
IUUC-Mmu-063945	Mus musculus	63.84	0.00e+00	886.00
IUUC-Mpu-065944	Mustela putorius furo	63.80	0.00e+00	860.00
IUUC-Mlu-067049	Myotis lucifugus	66.26	0.00e+00	877.00
IUUC-Nle-069828	Nomascus leucogenys	67.21	0.00e+00	935.00
IUUC-Opr-070672	Ochotona princeps	60.75	1.00e-119	423.00
IUUC-Ont-072121	Oreochromis niloticus	62.10	3.00e-152	531.00
IUUC-Oan-073656	Ornithorhynchus anatinus	70.70	0.00e+00	990.00
IUUC-Ocu-074323	Oryctolagus cuniculus	66.71	0.00e+00	890.00
IUUC-Ola-087238	Oryzias latipes	57.82	8.00e-166	577.00
IUUC-Oga-088379	Otolemur garnettii	64.41	0.00e+00	862.00
IUUC-Oar-089718	Ovis aries	67.62	0.00e+00	919.00
IUUC-Ptr-091358	Pan troglodytes	66.76	0.00e+00	932.00
IUUC-Pan-092023	Papio anubis	67.08	0.00e+00	926.00
IUUC-Psi-093256	Pelodiscus sinensis	82.35	0.00e+00	1078.00
IUUC-Ppa-095584	Physcomitrella patens	30.69	3.00e-38	154.00
IUUC-Pfo-097285	Poecilia formosa	49.60	1.00e-179	623.00
IUUC-Pab-098539	Pongo abelii	66.89	0.00e+00	936.00
IUUC-Pca-100610	Procavia capensis	55.88	0.00e+00	634.00
IUUC-Pva-102985	Pteropus vampyrus	75.27	3.00e-170	592.00
IUUC-Rno-105538	Rattus norvegicus	65.12	0.00e+00	889.00
IUUC-Sha-107022	Sarcophilus harrisii	77.38	0.00e+00	697.00
IUUC-Sar-113637	Sorex araneus	66.32	0.00e+00	643.00
IUUC-Ssc-115870	Sus scrofa	67.86	0.00e+00	943.00
IUUC-Tgu-116907	Taeniopygia guttata	96.81	0.00e+00	1388.00
IUUC-Tru-117835	Takifugu rubripes	55.53	5.00e-115	408.00
IUUC-Tsy-118869	Tarsius syrichta	66.88	0.00e+00	779.00
IUUC-Tni-119716	Tetraodon nigroviridis	61.20	2.00e-103	369.00
IUUC-Tbe-128041	Tupaia belangeri	52.29	5.00e-167	581.00
IUUC-Ttr-128901	Tursiops truncatus	63.46	0.00e+00	863.00
IUUC-Vpa-130331	Vicugna pacos	67.34	0.00e+00	899.00
IUUC-Xtr-131794	Xenopus tropicalis	55.92	0.00e+00	740.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence