iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023388

Ensembl Protein ID

ENSCSAP00000005102.1

UniProt Accession

A0A0D9R913; A0A0D9R913_CHLSB

Genbank Protein ID

ENSCSAP00000005102

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01142369

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000008844.1	ENSCSAT00000006908.1	ENSCSAP00000005102.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.70e-64	216.1	157	643

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 157  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 244
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 245  DSQQQDVSEFTHKLLDWLEDTFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 313
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 314  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 391
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 392  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqtlpstte 480
           ****8888888888888888888888888888888888888888888888888887777777777777777777777777777766555 PP
   S: 268  .........peekqke......................................................................... 274
                    p     +                                                                         
   Q: 481  qqgapsselP-----Stspssvaavssrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 564
           5555555550.....05555555666666666666666666666666666666666666677777777777777777777888888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 565  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 643
           88888888888**************************966556***************99997779************6 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MTLHQQTFLN QLREITGIND TQILQQALKD SNGNLELAVA FLTAKNAKTP QQEEATYYQT 60
ALPGNDRYIS VGSQADTNVI DLTGDDKDDL QRAIALSLAE SNRAFRETGI TDEEQAISRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCCTGG TCAGTCCTGT GGTTTCTGTG GTGTAAAGTG CGTAGGGGGT CCAGGCCTTT 60
GGGGTTACAG AGATCAGAGC TGCTCCCTCA GGTCGTGGGG GTCTTGTGCT TGGAGGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	93.51	0.00e+00	2016.00
IUUC-Apl-004030	Anas platyrhynchos	83.15	0.00e+00	1866.00
IUUC-Aca-004753	Anolis carolinensis	64.78	0.00e+00	1043.00
IUUC-Ame-010624	Astyanax mexicanus	70.94	0.00e+00	1131.00
IUUC-Bta-013166	Bos taurus	97.77	0.00e+00	1434.00
IUUC-Cel-018346	Caenorhabditis elegans	27.59	1.00e-27	119.00
IUUC-Cja-019150	Callithrix jacchus	99.10	0.00e+00	2126.00
IUUC-Cfa-020649	Canis familiaris	96.67	0.00e+00	2104.00
IUUC-Cpo-021807	Cavia porcellus	92.88	0.00e+00	2065.00
IUUC-Cho-024343	Choloepus hoffmanni	96.38	5.00e-152	531.00
IUUC-Cin-025302	Ciona intestinalis	37.17	3.00e-94	339.00
IUUC-Csv-025911	Ciona savignyi	34.01	7.00e-125	441.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	53.19	6.00e-10	60.50
IUUC-Dre-028016	Danio rerio	75.35	0.00e+00	1671.00
IUUC-Dno-029495	Dasypus novemcinctus	94.20	0.00e+00	2079.00
IUUC-Dor-030948	Dipodomys ordii	81.91	0.00e+00	1472.00
IUUC-Fca-035876	Felis catus	96.73	0.00e+00	1432.00
IUUC-Fal-036762	Ficedula albicollis	84.10	0.00e+00	1101.00
IUUC-Gmo-039490	Gadus morhua	71.48	0.00e+00	1554.00
IUUC-Gga-040817	Gallus gallus	85.32	0.00e+00	1932.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.54	0.00e+00	1581.00
IUUC-Ggo-044939	Gorilla gorilla	94.32	0.00e+00	1996.00
IUUC-Hsa-046204	Homo sapiens	99.35	0.00e+00	1441.00
IUUC-Kpa-049349	Komagataella pastoris	27.75	9.00e-10	59.70
IUUC-Lch-049572	Latimeria chalumnae	79.19	0.00e+00	1757.00
IUUC-Loc-052070	Lepisosteus oculatus	78.34	0.00e+00	1722.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	5.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	96.82	0.00e+00	1297.00
IUUC-Mcc-055858	Macaca mulatta	99.91	0.00e+00	2171.00
IUUC-Mga-059808	Meleagris gallopavo	85.99	0.00e+00	1330.00
IUUC-Mmr-060987	Microcebus murinus	97.48	0.00e+00	2096.00
IUUC-Mmu-064245	Mus musculus	93.20	0.00e+00	1423.00
IUUC-Mpu-066304	Mustela putorius furo	96.40	0.00e+00	2088.00
IUUC-Mlu-067139	Myotis lucifugus	94.25	0.00e+00	1462.00
IUUC-Nle-069075	Nomascus leucogenys	99.61	0.00e+00	1443.00
IUUC-Ont-072150	Oreochromis niloticus	73.62	0.00e+00	1672.00
IUUC-Oan-073054	Ornithorhynchus anatinus	79.87	0.00e+00	1742.00
IUUC-Ocu-074102	Oryctolagus cuniculus	94.64	0.00e+00	2096.00
IUUC-Ola-086529	Oryzias latipes	69.56	0.00e+00	1529.00
IUUC-Oga-088939	Otolemur garnettii	96.99	0.00e+00	1429.00
IUUC-Oar-090266	Ovis aries	96.31	0.00e+00	2095.00
IUUC-Ptr-090546	Pan troglodytes	99.21	0.00e+00	1438.00
IUUC-Pan-092311	Papio anubis	99.82	0.00e+00	2169.00
IUUC-Psi-093459	Pelodiscus sinensis	90.53	0.00e+00	1158.00
IUUC-Pfo-096726	Poecilia formosa	73.11	0.00e+00	1669.00
IUUC-Pab-097608	Pongo abelii	96.04	0.00e+00	2038.00
IUUC-Pca-100718	Procavia capensis	83.02	0.00e+00	1413.00
IUUC-Pva-103150	Pteropus vampyrus	90.98	0.00e+00	1498.00
IUUC-Rno-105727	Rattus norvegicus	93.99	0.00e+00	1390.00
IUUC-Sha-107051	Sarcophilus harrisii	89.28	0.00e+00	1352.00
IUUC-Sar-113097	Sorex araneus	85.50	0.00e+00	1829.00
IUUC-Ssc-115877	Sus scrofa	94.74	0.00e+00	1422.00
IUUC-Tgu-117473	Taeniopygia guttata	76.62	0.00e+00	1669.00
IUUC-Tru-118135	Takifugu rubripes	65.59	0.00e+00	1398.00
IUUC-Tsy-119471	Tarsius syrichta	89.78	0.00e+00	1842.00
IUUC-Tni-120139	Tetraodon nigroviridis	72.45	0.00e+00	1003.00
IUUC-Tbe-127549	Tupaia belangeri	87.75	0.00e+00	1864.00
IUUC-Ttr-128896	Tursiops truncatus	89.64	0.00e+00	1938.00
IUUC-Vpa-130500	Vicugna pacos	93.58	0.00e+00	1329.00
IUUC-Xtr-132896	Xenopus tropicalis	81.09	0.00e+00	1254.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence