iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117473

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01024757

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000013545.1	ENSTGUT00000014105.1	ENSTGUP00000013946.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-63	215.0	169	649
UBD/Alpha-Helix/UBA	8.00e-06	25.7	19	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+     + ++l+++++++++ +++++l+ lf+ l+ sk+k+v+p++ +++lk++ ++ +
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNfnppANAQDLPRNQKEHRNLPFMRELRYLFALLVGSKRKYVDPSRAVEILKDAFKS-N 256
           6*******************************9999999999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le++++                   + +ee++ +k k+++++lF g++    + +  +++ + +e f +++l
   Q: 257  DSQQQDVSEFTHKLLDWLEDAFQ------------------IKAEEERDGEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 325
           **********************2..................22345678999**************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp  L l++
   Q: 326  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSAKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPPILYLDR 403
           ******.....9**************96...899998754...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 404  YMHKnreitrikrdeikrlkeyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddlgasapasgtlppqippstie 492
           ****8888888888888888888888888888888888877777777777777777777777777777777777777777777776666 PP
   S: 268  ..............................peekqke.................................................... 274
                                         p     +                                                    
   Q: 493  qqgpsssdvpstspvqrsvihkpftqsripP-----Dlpmhpaprhiteeelsvlegclhrwrtevendtrdlqesisrihrtielmys 576
           6666666665555555555555555555550.....05555555555555555566666666666666666666777777777777777 PP
   S: 275  .....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                ++ Y+L+av+vH+G+++ GHY+ay+++++++ W++++D +Vt++++ee ++++      ++aY+l+Y 
   Q: 577  dktmvQVPYRLHAVLVHEGQANAGHYWAYIYDHHQNrWMKYNDISVTKSTWEELERDSFggyrnASAYCLMYI 649
           77777***************************77667*******************8779************6 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlve.MGF.dreealqaLraannnleaAveyL 38
             l+ql+e +G+ d +  ++aL ++n+nle Av++L
   Q: 19   TFLNQLREiTGInDIQVLQKALKDSNGNLELAVAFL 54
           569*******************************98 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MRADGEFVEE KATSRHQQTF LNQLREITGI NDIQVLQKAL KDSNGNLELA VAFLTAKNAK 60
VPQLEEATYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL EESNRAFRET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGGCAG ATGGTGAATT TGTGGAAGAG AAGGCCACCA GTCGAGTTTT TAGCTGCCTT 60
ATGCAGTTTT ACAATTGTTT CTGAAGATCT GTTAGTCTAT TAGCAAGTAT TAAAAGAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	79.28	0.00e+00	1693.00
IUUC-Apl-004030	Anas platyrhynchos	91.18	0.00e+00	1930.00
IUUC-Aca-004753	Anolis carolinensis	64.49	0.00e+00	968.00
IUUC-Ame-010624	Astyanax mexicanus	69.03	0.00e+00	1036.00
IUUC-Bta-013166	Bos taurus	78.77	0.00e+00	1652.00
IUUC-Cel-018346	Caenorhabditis elegans	28.35	3.00e-28	120.00
IUUC-Cja-019150	Callithrix jacchus	75.51	0.00e+00	1662.00
IUUC-Cfa-020649	Canis familiaris	75.93	0.00e+00	1675.00
IUUC-Cpo-021807	Cavia porcellus	78.95	0.00e+00	1754.00
IUUC-Csa-023388	Chlorocebus sabaeus	76.17	0.00e+00	1675.00
IUUC-Cho-024343	Choloepus hoffmanni	63.68	0.00e+00	767.00
IUUC-Cin-025302	Ciona intestinalis	37.35	3.00e-97	348.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.56	1.00e-10	62.00
IUUC-Cme-027167	Cyanidioschyzon merolae	25.06	2.00e-13	71.20
IUUC-Dre-028016	Danio rerio	68.39	0.00e+00	1514.00
IUUC-Dno-029495	Dasypus novemcinctus	74.15	0.00e+00	1674.00
IUUC-Dor-030948	Dipodomys ordii	66.89	0.00e+00	1164.00
IUUC-Fca-035876	Felis catus	79.40	0.00e+00	1681.00
IUUC-Fal-036762	Ficedula albicollis	99.06	0.00e+00	1267.00
IUUC-Fox-037752	Fusarium oxysporum	24.82	4.00e-17	84.00
IUUC-Gmo-039490	Gadus morhua	71.04	0.00e+00	1521.00
IUUC-Gga-040817	Gallus gallus	87.69	0.00e+00	1910.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.23	0.00e+00	1521.00
IUUC-Ggo-044939	Gorilla gorilla	76.40	0.00e+00	1629.00
IUUC-Hsa-046204	Homo sapiens	77.77	0.00e+00	1658.00
IUUC-Lch-049572	Latimeria chalumnae	75.00	0.00e+00	1630.00
IUUC-Loc-052070	Lepisosteus oculatus	72.45	0.00e+00	1546.00
IUUC-Laf-054426	Loxodonta africana	78.19	0.00e+00	1551.00
IUUC-Mcc-055858	Macaca mulatta	75.42	0.00e+00	1684.00
IUUC-Mga-059808	Meleagris gallopavo	90.05	0.00e+00	1902.00
IUUC-Mmr-060987	Microcebus murinus	76.36	0.00e+00	1660.00
IUUC-Mmu-064245	Mus musculus	77.12	0.00e+00	1667.00
IUUC-Mpu-066304	Mustela putorius furo	76.23	0.00e+00	1666.00
IUUC-Mlu-067139	Myotis lucifugus	79.21	0.00e+00	1712.00
IUUC-Nle-069075	Nomascus leucogenys	77.49	0.00e+00	1648.00
IUUC-Ont-072150	Oreochromis niloticus	76.18	0.00e+00	1210.00
IUUC-Oan-073054	Ornithorhynchus anatinus	76.37	0.00e+00	1595.00
IUUC-Ocu-074102	Oryctolagus cuniculus	74.44	0.00e+00	1672.00
IUUC-Ola-086529	Oryzias latipes	68.91	0.00e+00	1461.00
IUUC-Oga-088939	Otolemur garnettii	79.27	0.00e+00	1662.00
IUUC-Oar-090266	Ovis aries	76.62	0.00e+00	1660.00
IUUC-Ptr-090546	Pan troglodytes	77.77	0.00e+00	1654.00
IUUC-Pan-092311	Papio anubis	75.33	0.00e+00	1684.00
IUUC-Psi-093459	Pelodiscus sinensis	94.98	0.00e+00	1233.00
IUUC-Pfo-096726	Poecilia formosa	66.84	0.00e+00	1501.00
IUUC-Pab-097608	Pongo abelii	78.96	0.00e+00	1670.00
IUUC-Pca-100718	Procavia capensis	77.87	0.00e+00	1118.00
IUUC-Pva-103150	Pteropus vampyrus	75.24	0.00e+00	1255.00
IUUC-Pte-104300	Pyrenophora teres	24.00	9.00e-15	75.90
IUUC-Rno-105727	Rattus norvegicus	76.66	0.00e+00	1634.00
IUUC-Sha-107051	Sarcophilus harrisii	81.13	0.00e+00	1731.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.44	2.00e-09	58.20
IUUC-Sar-113097	Sorex araneus	74.35	0.00e+00	1569.00
IUUC-Ssc-115877	Sus scrofa	75.78	0.00e+00	1640.00
IUUC-Tru-118135	Takifugu rubripes	64.22	0.00e+00	1320.00
IUUC-Tsy-119471	Tarsius syrichta	75.12	0.00e+00	1506.00
IUUC-Tni-120139	Tetraodon nigroviridis	63.81	0.00e+00	1222.00
IUUC-Tbe-127549	Tupaia belangeri	75.47	0.00e+00	1587.00
IUUC-Ttr-128896	Tursiops truncatus	75.25	0.00e+00	1596.00
IUUC-Vpa-130500	Vicugna pacos	74.21	0.00e+00	1556.00
IUUC-Xtr-132896	Xenopus tropicalis	77.88	0.00e+00	1683.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence