iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001569

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF152; RING finger protein 152; RING-type E3 ubiquitin transferase RNF152

Genbank Nucleotide ID

GL192540

Gene Name

RNF152; PANDA_005868

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000019059.1	ENSAMET00000020895.1	ENSAMEP00000020126.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.40e-06	27.6	12	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +  ++ p++l+C+H+ +  Clq++    + s+k  rCP+Cr
   Q: 12   CQICFNYYspRRRPKLLDCKHTCCSVCLQQM----RTSQKDVRCPWCR 55
           9*****8888555***************999....99**********8 PP

Organism

Ailuropoda melanoleuca

Functional Description
(View)

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.

Protein Sequence
(Fasta)

METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGITKL 60
PPGFSVAQLP DDPEVLAVIA IPHASEHTPV FIKLPSNGCY MLPLPISKER ALLPGDMGCR 120

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Nucleotide Sequence
(Fasta)

ATGGAGACGC TCTCCCAAGA TTCCTTGCTG GAATGTCAGA TCTGTTTCAA TTACTACAGC 60
CCCCGGCGAA GGCCCAAGTT GCTGGATTGC AAACACACCT GCTGCTCGGT GTGCCTCCAG 120

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Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033609--RNF152
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0031301--C:integral component of organelle membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0034198--P:cellular response to amino acid starvation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0010508--P:positive regulation of autophagy
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

aml:100463900

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004700	Anolis carolinensis	91.63	1.00e-109	388.00
IUUC-Ame-011661	Astyanax mexicanus	54.90	2.00e-49	188.00
IUUC-Cja-019799	Callithrix jacchus	95.57	2.00e-105	374.00
IUUC-Cfa-020144	Canis familiaris	95.07	1.00e-100	358.00
IUUC-Cpo-021632	Cavia porcellus	96.55	2.00e-114	404.00
IUUC-Csa-023858	Chlorocebus sabaeus	96.06	7.00e-106	375.00
IUUC-Cho-024669	Choloepus hoffmanni	95.16	2.00e-68	250.00
IUUC-Dre-027881	Danio rerio	57.84	1.00e-56	211.00
IUUC-Dno-029695	Dasypus novemcinctus	90.64	4.00e-98	350.00
IUUC-Dor-030795	Dipodomys ordii	95.57	1.00e-103	368.00
IUUC-Eca-033412	Equus caballus	97.04	1.00e-106	378.00
IUUC-Fca-036256	Felis catus	97.04	3.00e-106	377.00
IUUC-Fal-036943	Ficedula albicollis	91.13	1.00e-101	361.00
IUUC-Gga-040800	Gallus gallus	91.63	7.00e-110	389.00
IUUC-Ggo-045477	Gorilla gorilla	96.55	2.00e-114	404.00
IUUC-Hsa-046568	Homo sapiens	96.55	2.00e-114	404.00
IUUC-Itr-049081	Ictidomys tridecemlineatus	96.06	2.00e-113	401.00
IUUC-Lch-049770	Latimeria chalumnae	84.24	1.00e-95	342.00
IUUC-Loc-052353	Lepisosteus oculatus	86.96	2.00e-60	223.00
IUUC-Laf-054064	Loxodonta africana	94.58	6.00e-112	395.00
IUUC-Mcc-054875	Macaca mulatta	96.06	7.00e-106	375.00
IUUC-Meu-056370	Macropus eugenii	93.63	1.00e-110	391.00
IUUC-Mga-059847	Meleagris gallopavo	91.63	7.00e-110	389.00
IUUC-Mmr-061042	Microcebus murinus	95.57	1.00e-112	398.00
IUUC-Mdo-063047	Monodelphis domestica	93.63	7.00e-111	392.00
IUUC-Mmu-064228	Mus musculus	96.06	2.00e-107	381.00
IUUC-Mlu-067736	Myotis lucifugus	96.06	8.00e-101	358.00
IUUC-Nle-069697	Nomascus leucogenys	96.06	7.00e-106	375.00
IUUC-Ont-072208	Oreochromis niloticus	75.12	3.00e-86	310.00
IUUC-Oan-073566	Ornithorhynchus anatinus	84.24	3.00e-89	320.00
IUUC-Ocu-074089	Oryctolagus cuniculus	94.58	6.00e-101	359.00
IUUC-Ola-087210	Oryzias latipes	69.90	4.00e-75	273.00
IUUC-Oga-088395	Otolemur garnettii	95.57	1.00e-103	368.00
IUUC-Oar-090382	Ovis aries	97.92	7.00e-22	94.70
IUUC-Ptr-091480	Pan troglodytes	96.55	2.00e-114	404.00
IUUC-Pan-091715	Papio anubis	96.06	7.00e-106	375.00
IUUC-Psi-093465	Pelodiscus sinensis	92.12	9.00e-110	388.00
IUUC-Pfo-097259	Poecilia formosa	76.42	1.00e-90	325.00
IUUC-Pab-097769	Pongo abelii	96.55	2.00e-114	404.00
IUUC-Pca-100657	Procavia capensis	95.07	1.00e-111	395.00
IUUC-Pva-102521	Pteropus vampyrus	96.55	1.00e-114	405.00
IUUC-Rno-105521	Rattus norvegicus	97.04	3.00e-115	406.00
IUUC-Sha-107197	Sarcophilus harrisii	94.12	7.00e-111	392.00
IUUC-Ssc-116239	Sus scrofa	95.57	3.00e-113	400.00
IUUC-Tru-118315	Takifugu rubripes	75.36	1.00e-83	301.00
IUUC-Tsy-119645	Tarsius syrichta	97.04	1.00e-114	405.00
IUUC-Tni-119835	Tetraodon nigroviridis	72.99	5.00e-86	310.00
IUUC-Tbe-127264	Tupaia belangeri	96.06	2.00e-108	384.00
IUUC-Ttr-128749	Tursiops truncatus	97.04	3.00e-108	384.00
IUUC-Vpa-130808	Vicugna pacos	97.04	2.00e-108	384.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence