iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-092933

Ensembl Protein ID

ENSPSIP00000009906.1

UniProt Accession

K7FPE6; K7FPE6_PELSI

Genbank Protein ID

ENSPSIP00000009906

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01091032

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000009001.1	ENSPSIT00000009956.1	ENSPSIP00000009906.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-08	35.2	549	587

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 549  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 587
           ********999******************......********** PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

GMAAPGPPHL PGLGPRLRAG LEVALRVPSL FLIDAIFNSY PLPGGSLYAG LLGVLLRLLG 60
VFVSSVVLVL QQRALFKFYM ISSAFLLAAT SVLVNYYASL HINFYSAYYT AAFGIQFLPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAACATGGA GGCGGCCGCA GTGCGGGGGG CCAGGCCCGT CCGGGAGGCG GGAACAGGAC 60
TATAGCTGGT CTCTGAGCCA GAGACCGGTA CGAGGCGGCG GGTCCCTGGG GATGGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	80.84	0.00e+00	940.00
IUUC-Apl-004214	Anas platyrhynchos	89.56	0.00e+00	1010.00
IUUC-Aca-005326	Anolis carolinensis	86.93	0.00e+00	1014.00
IUUC-Ame-011687	Astyanax mexicanus	74.92	0.00e+00	827.00
IUUC-Bta-013394	Bos taurus	81.26	0.00e+00	961.00
IUUC-Cja-019499	Callithrix jacchus	80.48	0.00e+00	965.00
IUUC-Cfa-020357	Canis familiaris	81.29	0.00e+00	946.00
IUUC-Cpo-021924	Cavia porcellus	84.21	0.00e+00	942.00
IUUC-Csa-023513	Chlorocebus sabaeus	81.26	0.00e+00	961.00
IUUC-Cho-024285	Choloepus hoffmanni	75.61	0.00e+00	811.00
IUUC-Cin-025223	Ciona intestinalis	53.18	8.00e-74	269.00
IUUC-Csv-026018	Ciona savignyi	47.62	2.00e-65	242.00
IUUC-Dre-028660	Danio rerio	72.97	0.00e+00	751.00
IUUC-Dno-029463	Dasypus novemcinctus	90.82	4.00e-109	388.00
IUUC-Dor-030728	Dipodomys ordii	85.35	0.00e+00	926.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	6.00e-09	54.30
IUUC-Dme-032186	Drosophila melanogaster	48.20	6.00e-99	355.00
IUUC-Ete-032368	Echinops telfairi	79.25	0.00e+00	947.00
IUUC-Eca-034325	Equus caballus	80.68	0.00e+00	941.00
IUUC-Fca-035537	Felis catus	81.20	0.00e+00	936.00
IUUC-Fal-037459	Ficedula albicollis	90.19	0.00e+00	1003.00
IUUC-Fso-038284	Fusarium solani	31.03	7.00e-09	55.50
IUUC-Gmo-039442	Gadus morhua	78.73	3.00e-99	355.00
IUUC-Gga-041071	Gallus gallus	90.05	0.00e+00	1075.00
IUUC-Gac-042483	Gasterosteus aculeatus	72.73	0.00e+00	864.00
IUUC-Ggo-044672	Gorilla gorilla	81.26	0.00e+00	959.00
IUUC-Hsa-045836	Homo sapiens	80.61	0.00e+00	934.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	83.98	0.00e+00	969.00
IUUC-Lch-050073	Latimeria chalumnae	78.01	0.00e+00	933.00
IUUC-Loc-052908	Lepisosteus oculatus	77.54	0.00e+00	908.00
IUUC-Laf-053519	Loxodonta africana	80.78	0.00e+00	970.00
IUUC-Mga-059922	Meleagris gallopavo	90.19	0.00e+00	988.00
IUUC-Mmr-061452	Microcebus murinus	82.07	0.00e+00	961.00
IUUC-Mdo-062412	Monodelphis domestica	83.82	0.00e+00	981.00
IUUC-Mmu-063147	Mus musculus	80.55	0.00e+00	963.00
IUUC-Mpu-065929	Mustela putorius furo	81.13	0.00e+00	947.00
IUUC-Mlu-067899	Myotis lucifugus	81.37	0.00e+00	944.00
IUUC-Nle-070083	Nomascus leucogenys	81.26	0.00e+00	959.00
IUUC-Opr-070461	Ochotona princeps	79.77	0.00e+00	943.00
IUUC-Ont-072256	Oreochromis niloticus	72.44	0.00e+00	861.00
IUUC-Oan-073150	Ornithorhynchus anatinus	83.30	0.00e+00	872.00
IUUC-Ocu-073748	Oryctolagus cuniculus	80.42	0.00e+00	925.00
IUUC-Oga-088565	Otolemur garnettii	83.00	0.00e+00	955.00
IUUC-Oar-089432	Ovis aries	84.85	0.00e+00	948.00
IUUC-Ptr-091422	Pan troglodytes	81.10	0.00e+00	959.00
IUUC-Pan-092331	Papio anubis	81.26	0.00e+00	962.00
IUUC-Pfo-097466	Poecilia formosa	71.95	0.00e+00	850.00
IUUC-Pab-098702	Pongo abelii	81.26	0.00e+00	959.00
IUUC-Pca-100125	Procavia capensis	79.48	0.00e+00	949.00
IUUC-Pva-102628	Pteropus vampyrus	80.97	0.00e+00	945.00
IUUC-Rno-104886	Rattus norvegicus	82.61	0.00e+00	967.00
IUUC-Sha-106702	Sarcophilus harrisii	82.36	0.00e+00	967.00
IUUC-Ssc-116164	Sus scrofa	82.16	0.00e+00	972.00
IUUC-Tgu-116829	Taeniopygia guttata	90.47	0.00e+00	1038.00
IUUC-Tru-118557	Takifugu rubripes	73.15	0.00e+00	823.00
IUUC-Tsy-119399	Tarsius syrichta	80.20	4.00e-165	573.00
IUUC-Tni-120006	Tetraodon nigroviridis	65.44	0.00e+00	712.00
IUUC-Tbe-127664	Tupaia belangeri	80.06	0.00e+00	942.00
IUUC-Ttr-129144	Tursiops truncatus	81.77	0.00e+00	983.00
IUUC-Vpa-130226	Vicugna pacos	81.42	0.00e+00	960.00
IUUC-Xtr-132461	Xenopus tropicalis	76.99	0.00e+00	854.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence