iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066815

Ensembl Protein ID

ENSMPUP00000010748.1

UniProt Accession

M3YHE1; M3YHE1_MUSPF

Genbank Protein ID

ENSMPUP00000010748

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01061214

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010836.1	ENSMPUT00000010927.1	ENSMPUP00000010748.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-45	152.5	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEYP ANGGGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCCCTATG TTCCTTTTAT ACGAGTGATT GCCCAGATCA TAATTCTCTG CTGAGATTTG 60
GGGTTTTTTT TCAAGAATTT GGAGAATCCC TGCAGCTTTG TAACTTCAAG TGTGTCACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	100.00	0.00e+00	769.00
IUUC-Apl-003456	Anas platyrhynchos	92.37	0.00e+00	723.00
IUUC-Aca-005105	Anolis carolinensis	91.58	0.00e+00	718.00
IUUC-Ame-010966	Astyanax mexicanus	78.65	4.00e-176	610.00
IUUC-Bta-012424	Bos taurus	88.95	0.00e+00	653.00
IUUC-Cel-018144	Caenorhabditis elegans	41.91	3.00e-76	278.00
IUUC-Cja-019898	Callithrix jacchus	97.37	0.00e+00	752.00
IUUC-Cfa-020830	Canis familiaris	98.95	0.00e+00	762.00
IUUC-Cpo-021487	Cavia porcellus	87.63	0.00e+00	654.00
IUUC-Csa-023693	Chlorocebus sabaeus	97.37	0.00e+00	751.00
IUUC-Cin-025348	Ciona intestinalis	38.00	3.00e-67	248.00
IUUC-Dre-028334	Danio rerio	81.46	2.00e-180	625.00
IUUC-Dno-028973	Dasypus novemcinctus	93.95	0.00e+00	731.00
IUUC-Dor-031003	Dipodomys ordii	95.00	0.00e+00	704.00
IUUC-Ete-032792	Echinops telfairi	85.42	0.00e+00	657.00
IUUC-Eca-033656	Equus caballus	98.68	0.00e+00	761.00
IUUC-Fca-036347	Felis catus	99.74	0.00e+00	766.00
IUUC-Fal-037095	Ficedula albicollis	92.11	0.00e+00	724.00
IUUC-Gmo-039410	Gadus morhua	71.68	5.00e-162	563.00
IUUC-Gga-040155	Gallus gallus	92.37	0.00e+00	723.00
IUUC-Gac-041787	Gasterosteus aculeatus	74.11	4.00e-167	580.00
IUUC-Ggo-044805	Gorilla gorilla	97.63	0.00e+00	753.00
IUUC-Hsa-046585	Homo sapiens	97.63	0.00e+00	753.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	95.79	0.00e+00	720.00
IUUC-Lch-049795	Latimeria chalumnae	88.42	0.00e+00	694.00
IUUC-Loc-051985	Lepisosteus oculatus	87.89	0.00e+00	666.00
IUUC-Laf-054228	Loxodonta africana	95.26	0.00e+00	738.00
IUUC-Mcc-055402	Macaca mulatta	97.37	0.00e+00	751.00
IUUC-Mga-059374	Meleagris gallopavo	92.37	0.00e+00	723.00
IUUC-Mmr-061453	Microcebus murinus	97.37	0.00e+00	751.00
IUUC-Mdo-063080	Monodelphis domestica	91.58	0.00e+00	719.00
IUUC-Mmu-063529	Mus musculus	94.74	0.00e+00	718.00
IUUC-Mlu-067132	Myotis lucifugus	95.41	5.00e-166	576.00
IUUC-Nle-069371	Nomascus leucogenys	97.63	0.00e+00	753.00
IUUC-Opr-070948	Ochotona princeps	96.55	0.00e+00	706.00
IUUC-Ont-071410	Oreochromis niloticus	76.07	5.00e-164	570.00
IUUC-Oan-073304	Ornithorhynchus anatinus	90.85	8.00e-164	569.00
IUUC-Ocu-074783	Oryctolagus cuniculus	97.11	0.00e+00	726.00
IUUC-Ola-086808	Oryzias latipes	73.78	5.00e-161	560.00
IUUC-Oga-088391	Otolemur garnettii	97.63	0.00e+00	733.00
IUUC-Oar-090025	Ovis aries	82.63	9.00e-170	588.00
IUUC-Ptr-090975	Pan troglodytes	97.63	0.00e+00	753.00
IUUC-Pan-092287	Papio anubis	97.37	0.00e+00	751.00
IUUC-Psi-093413	Pelodiscus sinensis	92.63	0.00e+00	725.00
IUUC-Pfo-097129	Poecilia formosa	77.22	1.00e-169	588.00
IUUC-Pab-098756	Pongo abelii	97.63	0.00e+00	753.00
IUUC-Pca-100235	Procavia capensis	81.84	0.00e+00	648.00
IUUC-Pva-102294	Pteropus vampyrus	95.26	0.00e+00	723.00
IUUC-Rno-105090	Rattus norvegicus	94.74	0.00e+00	719.00
IUUC-Sha-107521	Sarcophilus harrisii	92.11	0.00e+00	724.00
IUUC-Sar-113697	Sorex araneus	89.58	0.00e+00	674.00
IUUC-Ssc-115958	Sus scrofa	87.97	1.00e-167	582.00
IUUC-Tgu-116559	Taeniopygia guttata	90.26	0.00e+00	698.00
IUUC-Tru-117677	Takifugu rubripes	76.71	2.00e-168	584.00
IUUC-Tni-120434	Tetraodon nigroviridis	77.26	2.00e-166	578.00
IUUC-Tbe-127931	Tupaia belangeri	95.57	0.00e+00	632.00
IUUC-Ttr-128993	Tursiops truncatus	88.95	0.00e+00	656.00
IUUC-Xtr-132543	Xenopus tropicalis	84.78	0.00e+00	676.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence