iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000004291.9	ENSDART00000142835.1	ENSDARP00000116253.1
ENSDARG00000004291.9	ENSDART00000029412.7	ENSDARP00000031155.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-121	405.0	1220	1552

Active Site

Position(s)	Description	Evidence
1520	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1220 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1305
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ + +l+dle +d+e+++sl+++ken   di++  ldltf+v+ee++g+++e+eLk+gG n++Vt++Nk+eY+++
   Q: 1306 AFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKEN---DITDV-LDLTFTVNEEVFGQVTERELKSGGTNVQVTEKNKKEYIER 1388
           ************************************99...9***8.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q++a+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1389 MVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWGAVERFNNEQRLR 1475
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gf +l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1476 LLQFVTGTSSVPYEGFTALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTFGLE 1552
           ************************999***********************************************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MNEEVMIHRQ VILTQNLYQS RFLGLAAMAS PSRASQGRRR CKDPIRHSFN PEQFPNVDFQ 60
NGVAEDLAAA VLRSTSDTDL LTSHCRSTLT VSTSSYTIGQ TQDITLSWDI KEEVDAGDWI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACAGAAATC AATCTGACGG AGCGTTTCCA TTGGTTACAG CCTCCTGGTA CCCAGGAAAG 60
AGGATGTAGC ATCTCCTGCA GTAGCATAGC AAACAGGGCA TATGAGAGGA AAGGGCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:563730

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	80.64	0.00e+00	1387.00
IUUC-Apl-003299	Anas platyrhynchos	73.39	0.00e+00	1513.00
IUUC-Aca-005024	Anolis carolinensis	73.09	0.00e+00	1496.00
IUUC-Bta-012604	Bos taurus	80.62	0.00e+00	1417.00
IUUC-Cja-019880	Callithrix jacchus	74.89	0.00e+00	1336.00
IUUC-Cfa-021216	Canis familiaris	80.07	0.00e+00	1430.00
IUUC-Cpo-021466	Cavia porcellus	80.11	0.00e+00	1427.00
IUUC-Csa-023080	Chlorocebus sabaeus	80.73	0.00e+00	1440.00
IUUC-Cho-024740	Choloepus hoffmanni	84.23	0.00e+00	1050.00
IUUC-Dno-030019	Dasypus novemcinctus	72.16	0.00e+00	1494.00
IUUC-Ete-032352	Echinops telfairi	85.48	0.00e+00	1159.00
IUUC-Eca-033948	Equus caballus	80.44	0.00e+00	1427.00
IUUC-Eeu-034474	Erinaceus europaeus	63.88	0.00e+00	761.00
IUUC-Fca-036148	Felis catus	80.29	0.00e+00	1420.00
IUUC-Fal-036957	Ficedula albicollis	73.49	0.00e+00	1517.00
IUUC-Gmo-038714	Gadus morhua	67.66	0.00e+00	1016.00
IUUC-Gga-041194	Gallus gallus	71.82	0.00e+00	1526.00
IUUC-Gac-041366	Gasterosteus aculeatus	79.52	0.00e+00	1356.00
IUUC-Ggo-045442	Gorilla gorilla	70.13	0.00e+00	1318.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	79.93	0.00e+00	1429.00
IUUC-Lch-050185	Latimeria chalumnae	68.30	0.00e+00	1280.00
IUUC-Loc-052744	Lepisosteus oculatus	74.34	0.00e+00	1525.00
IUUC-Laf-054368	Loxodonta africana	86.19	0.00e+00	1349.00
IUUC-Mcc-055487	Macaca mulatta	80.62	0.00e+00	1437.00
IUUC-Meu-056751	Macropus eugenii	89.50	0.00e+00	714.00
IUUC-Mga-059545	Meleagris gallopavo	73.18	0.00e+00	1522.00
IUUC-Mmr-061078	Microcebus murinus	69.91	0.00e+00	1414.00
IUUC-Mdo-062176	Monodelphis domestica	80.64	0.00e+00	1386.00
IUUC-Mmu-063513	Mus musculus	79.28	0.00e+00	1398.00
IUUC-Mpu-065786	Mustela putorius furo	80.55	0.00e+00	1425.00
IUUC-Mlu-067780	Myotis lucifugus	77.43	0.00e+00	1249.00
IUUC-Nle-069213	Nomascus leucogenys	80.73	0.00e+00	1439.00
IUUC-Opr-070208	Ochotona princeps	85.04	0.00e+00	1340.00
IUUC-Ont-072132	Oreochromis niloticus	77.84	0.00e+00	1352.00
IUUC-Oan-072807	Ornithorhynchus anatinus	81.98	0.00e+00	1426.00
IUUC-Ocu-074745	Oryctolagus cuniculus	80.61	0.00e+00	1429.00
IUUC-Ola-086981	Oryzias latipes	75.41	0.00e+00	1372.00
IUUC-Oga-087965	Otolemur garnettii	80.62	0.00e+00	1393.00
IUUC-Oar-089749	Ovis aries	80.40	0.00e+00	1412.00
IUUC-Ptr-091243	Pan troglodytes	80.73	0.00e+00	1440.00
IUUC-Pan-092201	Papio anubis	80.73	0.00e+00	1441.00
IUUC-Psi-093511	Pelodiscus sinensis	72.17	0.00e+00	1515.00
IUUC-Pfo-097001	Poecilia formosa	78.87	0.00e+00	1365.00
IUUC-Pca-100129	Procavia capensis	70.02	0.00e+00	1085.00
IUUC-Pva-102250	Pteropus vampyrus	76.70	0.00e+00	1346.00
IUUC-Rno-105031	Rattus norvegicus	70.72	0.00e+00	1456.00
IUUC-Tgu-117515	Taeniopygia guttata	72.80	0.00e+00	1511.00
IUUC-Tru-117914	Takifugu rubripes	78.95	0.00e+00	1370.00
IUUC-Tni-120178	Tetraodon nigroviridis	74.84	0.00e+00	1358.00
IUUC-Tbe-127762	Tupaia belangeri	67.82	0.00e+00	1359.00
IUUC-Ttr-128806	Tursiops truncatus	80.13	0.00e+00	1417.00
IUUC-Xtr-132903	Xenopus tropicalis	81.63	0.00e+00	1456.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence