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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032034
UUCD1 version UUC-DrM-00392
Ensembl Protein ID FBpp0310889
UniProt Accession Q9VRP9; C3KGI2; Q8IGT1; Q95TN7; BRE1_DROME
Genbank Protein ID AAF50744.2; AAL13880.1; AAN71372.1; ACO95725.1
Protein Name E3 ubiquitin-protein ligase Bre1; RING-type E3 ubiquitin transferase Bre1; dBre1
Genbank Nucleotide ID AE014296; AY058651; BT001617; BT082047
Gene Name Bre1; CG10542
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0086694 FBtr0344538 FBpp0310889
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 23624310
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0007 20.1 991 1030
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+ C+   kd  ++  C Hvf+ dCl  ++      + ++ +CP C+
   Q: 991  CPSCKVKRKD-AVLSKCFHVFCYDCLrTRY------ETRQRKCPKCN 1030
           ****999999.78799**********99**......**********7 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.
 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.
Protein Sequence
(Fasta)
MSKRSADDAT GSSCLVAAAA AGQPPIKKVH FEPHLIGPVS TLEEMDIKVL EFQNKKLAQR 60
IEQRMRTEAE LRHRIEQLEK RQTQDDAVLN VVNRYWNQLN EDIRVLLQRF DAETADELEN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032034|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
TGTTACCGTG CTGCTGTGAA AATTCCCAGG TGTGACCGCA GCCCGCATTC GATATTGATG 60
AAGCCAGGCA AAACGTAGAA AAGCAAAAGA AAACCTTAAT TAATGTTAAG TTAAAAGTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032034|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016570--P:histone modification
GO:0016574--P:histone ubiquitination
GO:0007219--P:Notch signaling pathway
GO:0006909--P:phagocytosis
GO:0006513--P:protein monoubiquitination
GO:0030431--P:sleep
KEGG dme:Dmel_CG10542
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001027 Aegilops tauschii 37.23 4.00e-10 59.30
IUUC-Aml-002295 Ailuropoda melanoleuca 42.94 0.00e+00 705.00
IUUC-Atr-002836 Amborella trichopoda 28.95 3.00e-22 100.00
IUUC-Apl-003407 Anas platyrhynchos 55.32 1.00e-98 353.00
IUUC-Aca-004850 Anolis carolinensis 55.50 3.00e-106 379.00
IUUC-Aly-006055 Arabidopsis lyrata 26.40 1.00e-29 124.00
IUUC-Ath-007462 Arabidopsis thaliana 26.67 7.00e-30 125.00
IUUC-Ago-007988 Ashbya gossypii 22.84 3.00e-16 79.30
IUUC-Acl-008319 Aspergillus clavatus 23.08 7.00e-14 71.60
IUUC-Ang-009601 Aspergillus niger 24.41 6.00e-17 82.00
IUUC-Aor-010142 Aspergillus oryzae 23.98 7.00e-15 75.10
IUUC-Ate-010547 Aspergillus terreus 24.32 3.00e-14 72.80
IUUC-Ame-011916 Astyanax mexicanus 53.58 1.00e-96 347.00
IUUC-Bgr-012245 Blumeria graminis 26.14 5.00e-13 68.90
IUUC-Bta-013173 Bos taurus 42.90 0.00e+00 693.00
IUUC-Bci-013926 Botrytis cinerea 24.06 2.00e-08 53.90
IUUC-Bdi-014799 Brachypodium distachyon 28.31 1.00e-31 131.00
IUUC-Bol-015421 Brassica oleracea 27.32 2.00e-28 120.00
IUUC-Bra-016664 Brassica rapa 27.06 4.00e-28 119.00
IUUC-Cel-018659 Caenorhabditis elegans 39.06 2.00e-46 180.00
IUUC-Cja-019042 Callithrix jacchus 53.62 4.00e-107 382.00
IUUC-Cfa-020318 Canis familiaris 42.83 0.00e+00 704.00
IUUC-Cpo-021539 Cavia porcellus 42.20 0.00e+00 687.00
IUUC-Cre-022940 Chlamydomonas reinhardtii 30.56 3.00e-05 43.10
IUUC-Csa-024051 Chlorocebus sabaeus 54.79 2.00e-111 396.00
IUUC-Cho-024616 Choloepus hoffmanni 59.52 4.00e-76 279.00
IUUC-Cin-025174 Ciona intestinalis 52.92 1.00e-100 360.00
IUUC-Csv-025830 Ciona savignyi 39.63 4.00e-165 574.00
IUUC-Cgl-026569 Colletotrichum gloeosporioides 44.19 8.00e-09 55.10
IUUC-Cne-026878 Cryptococcus neoformans 26.64 4.00e-17 82.80
IUUC-Cme-027134 Cyanidioschyzon merolae 40.91 1.00e-13 70.90
IUUC-Dre-028146 Danio rerio 39.92 2.00e-158 552.00
IUUC-Dno-028892 Dasypus novemcinctus 54.79 1.00e-111 397.00
IUUC-Dor-030268 Dipodomys ordii 55.14 4.00e-110 391.00
IUUC-Dse-031300 Dothistroma septosporum 24.05 6.00e-13 68.60
IUUC-Ete-032505 Echinops telfairi 55.65 9.00e-62 231.00
IUUC-Eca-033436 Equus caballus 42.96 0.00e+00 711.00
IUUC-Eeu-035291 Erinaceus europaeus 38.64 7.00e-96 344.00
IUUC-Fca-035720 Felis catus 42.83 0.00e+00 708.00
IUUC-Fal-037622 Ficedula albicollis 38.80 2.00e-93 336.00
IUUC-Fox-038017 Fusarium oxysporum 40.43 1.00e-08 54.70
IUUC-Fso-038414 Fusarium solani 30.51 3.00e-08 53.10
IUUC-Gmo-039269 Gadus morhua 56.99 2.00e-100 360.00
IUUC-Ggr-040117 Gaeumannomyces graminis 37.74 3.00e-09 56.20
IUUC-Gga-040412 Gallus gallus 55.32 3.00e-98 352.00
IUUC-Gac-041303 Gasterosteus aculeatus 56.49 4.00e-101 362.00
IUUC-Gma-042797 Glycine max 25.43 4.00e-34 139.00
IUUC-Ggo-045426 Gorilla gorilla 42.75 0.00e+00 699.00
IUUC-Hsa-045732 Homo sapiens 42.36 0.00e+00 703.00
IUUC-Hvu-047689 Hordeum vulgare 27.06 8.00e-30 125.00
IUUC-Itr-048724 Ictidomys tridecemlineatus 54.79 1.00e-111 397.00
IUUC-Kpa-049345 Komagataella pastoris 30.65 5.00e-09 55.80
IUUC-Lch-049429 Latimeria chalumnae 57.03 3.00e-108 385.00
IUUC-Lpe-051253 Leersia perrieri 26.98 6.00e-29 122.00
IUUC-Loc-051951 Lepisosteus oculatus 46.27 2.00e-69 256.00
IUUC-Lma-053312 Leptosphaeria maculans 33.04 2.00e-14 73.20
IUUC-Laf-054267 Loxodonta africana 42.80 0.00e+00 701.00
IUUC-Mcc-055240 Macaca mulatta 54.79 2.00e-111 396.00
IUUC-Meu-056750 Macropus eugenii 42.38 0.00e+00 676.00
IUUC-Mor-057068 Magnaporthe oryzae 41.51 8.00e-11 61.60
IUUC-Mpo-057568 Magnaporthe poae 25.57 3.00e-10 59.70
IUUC-Mtr-058247 Medicago truncatula 30.96 3.00e-13 70.10
IUUC-Mla-059072 Melampsora laricipopulina 31.40 2.00e-26 114.00
IUUC-Mga-059731 Meleagris gallopavo 55.32 1.00e-97 350.00
IUUC-Mvi-060341 Microbotryum violaceum 25.29 5.00e-20 92.40
IUUC-Mmr-061177 Microcebus murinus 42.76 0.00e+00 699.00
IUUC-Mdo-062415 Monodelphis domestica 55.99 8.00e-111 394.00
IUUC-Mmu-063981 Mus musculus 43.03 0.00e+00 708.00
IUUC-Mac-065103 Musa acuminata 28.73 2.00e-38 153.00
IUUC-Mpu-066498 Mustela putorius furo 54.79 1.00e-111 396.00
IUUC-Mlu-067242 Myotis lucifugus 42.80 0.00e+00 692.00
IUUC-Ncr-068695 Neurospora crassa 40.00 2.00e-10 60.10
IUUC-Nle-069320 Nomascus leucogenys 47.65 6.00e-119 421.00
IUUC-Opr-070286 Ochotona princeps 41.31 1.00e-90 327.00
IUUC-Ont-071299 Oreochromis niloticus 55.93 3.00e-104 372.00
IUUC-Oan-073538 Ornithorhynchus anatinus 49.11 8.00e-68 251.00
IUUC-Ocu-073799 Oryctolagus cuniculus 43.26 0.00e+00 711.00
IUUC-Oba-075000 Oryza barthii 27.93 2.00e-28 120.00
IUUC-Obr-076532 Oryza brachyantha 27.01 4.00e-28 119.00
IUUC-Ogl-077200 Oryza glaberrima 27.79 7.00e-30 125.00
IUUC-Ogu-078279 Oryza glumaepatula 27.93 2.00e-28 120.00
IUUC-Oin-079097 Oryza indica 27.79 8.00e-30 125.00
IUUC-Olo-080612 Oryza longistaminata 27.45 2.00e-21 97.80
IUUC-Ome-081304 Oryza meridionalis 28.23 2.00e-29 123.00
IUUC-Oni-082162 Oryza nivara 27.93 2.00e-28 120.00
IUUC-Opu-083683 Oryza punctata 44.83 7.00e-14 72.00
IUUC-Oru-084382 Oryza rufipogon 27.93 2.00e-28 120.00
IUUC-Osa-085839 Oryza sativa 29.80 7.00e-23 102.00
IUUC-Ola-086435 Oryzias latipes 56.87 2.00e-103 369.00
IUUC-Olu-087683 Ostreococcus lucimarinus 33.64 8.00e-13 65.10
IUUC-Oga-089016 Otolemur garnettii 43.48 0.00e+00 643.00
IUUC-Oar-089589 Ovis aries 42.75 0.00e+00 695.00
IUUC-Ptr-090530 Pan troglodytes 41.98 2.00e-90 326.00
IUUC-Pan-092502 Papio anubis 54.79 2.00e-111 396.00
IUUC-Psi-093554 Pelodiscus sinensis 54.55 2.00e-94 339.00
IUUC-Pno-095079 Phaeosphaeria nodorum 43.64 3.00e-12 66.20
IUUC-Ppa-095332 Physcomitrella patens 31.91 1.00e-40 160.00
IUUC-Pfo-097527 Poecilia formosa 44.54 2.00e-141 495.00
IUUC-Pab-098619 Pongo abelii 42.22 0.00e+00 689.00
IUUC-Pop-099583 Populus trichocarpa 28.98 2.00e-34 138.00
IUUC-Pca-100544 Procavia capensis 42.78 0.00e+00 697.00
IUUC-Ppe-102065 Prunus persica 32.14 3.00e-30 126.00
IUUC-Pva-102479 Pteropus vampyrus 54.79 2.00e-111 395.00
IUUC-Pgr-103536 Puccinia graminis 30.31 3.00e-26 113.00
IUUC-Ptt-104014 Puccinia triticina 29.17 1.00e-03 38.10
IUUC-Pte-104415 Pyrenophora teres 45.45 2.00e-12 67.00
IUUC-Pyt-104762 Pyrenophora triticirepentis 45.45 2.00e-12 67.00
IUUC-Rno-105165 Rattus norvegicus 42.48 0.00e+00 697.00
IUUC-Sce-106384 Saccharomyces cerevisiae 22.99 1.00e-16 81.30
IUUC-Sha-107602 Sarcophilus harrisii 43.16 0.00e+00 701.00
IUUC-Sja-107993 Schizosaccharomyces japonicus 41.03 2.00e-11 63.90
IUUC-Spo-108304 Schizosaccharomyces pombe 43.08 3.00e-14 72.80
IUUC-Ssl-108546 Sclerotinia sclerotiorum 40.43 7.00e-08 52.00
IUUC-Smo-109550 Selaginella moellendorffii 30.36 2.00e-35 143.00
IUUC-Sit-109889 Setaria italica 27.71 3.00e-33 136.00
IUUC-Sly-111490 Solanum lycopersicum 28.83 5.00e-39 155.00
IUUC-Sar-113755 Sorex araneus 40.64 1.00e-144 506.00
IUUC-Sbi-114734 Sorghum bicolor 28.14 1.00e-26 112.00
IUUC-Sre-115087 Sporisorium reilianum 25.76 1.00e-16 80.90
IUUC-Ssc-116134 Sus scrofa 42.34 0.00e+00 692.00
IUUC-Tgu-116549 Taeniopygia guttata 55.32 1.00e-91 330.00
IUUC-Tru-118776 Takifugu rubripes 42.75 5.00e-145 508.00
IUUC-Tsy-119065 Tarsius syrichta 46.25 2.00e-125 442.00
IUUC-Tni-120790 Tetraodon nigroviridis 40.06 1.00e-164 573.00
IUUC-Tca-121060 Theobroma cacao 31.75 3.00e-38 152.00
IUUC-Tre-122150 Trichoderma reesei 37.74 3.00e-09 56.20
IUUC-Tvi-122431 Trichoderma virens 35.85 8.00e-09 55.10
IUUC-Tae-123217 Triticum aestivum 28.27 4.00e-25 109.00
IUUC-Tur-126160 Triticum urartu 24.81 4.00e-22 99.40
IUUC-Tme-127177 Tuber melanosporum 23.64 4.00e-12 65.90
IUUC-Tbe-127597 Tupaia belangeri 45.39 4.00e-151 528.00
IUUC-Ttr-128303 Tursiops truncatus 54.26 6.00e-109 387.00
IUUC-Uma-129488 Ustilago maydis 50.00 1.00e-16 80.90
IUUC-Vda-129815 Verticillium dahliae 26.09 4.00e-10 59.30
IUUC-Vpa-130237 Vicugna pacos 54.59 1.00e-98 353.00
IUUC-Vvi-131316 Vitis vinifera 28.61 2.00e-32 133.00
IUUC-Xtr-132906 Xenopus tropicalis 41.39 7.00e-99 354.00
IUUC-Xma-133365 Xiphophorus maculatus 44.29 1.00e-140 493.00
IUUC-Yli-134445 Yarrowia lipolytica 33.10 4.00e-12 65.90
IUUC-Zma-135598 Zea mays 28.50 6.00e-35 142.00
Created Date 25-Jun-2017

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