• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045732
UUCD1 version UUC-HoS-00034
Ensembl Protein ID ENSP00000325677.6
UniProt Accession O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82; BRE1B_HUMAN
Genbank Protein ID AAG13723.1; BAA31636.2; BAB55092.1; CAE45869.1; CAH10518.1; AAH04527.2; AAH06133.1; AAH11769.1; AAH18647.1; AAH30802.2
Protein Name E3 ubiquitin-protein ligase BRE1B; 95 kDa retinoblastoma-associated protein; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B
Genbank Nucleotide ID AF122819; AB014561; AK027406; BX640763; CR627431; AC106886; BC006133; BC011769; BC018647; BC030802
Gene Name RNF40; BRE1B; KIAA0661
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103549.21 ENST00000324685.10 ENSP00000325677.6
ENSG00000103549.21 ENST00000563683.5 ENSP00000455180.1
ENSG00000103549.21 ENST00000357890.9 ENSP00000350563.5
ENSG00000103549.21 ENST00000567365.2 ENSP00000477937.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16713563; 16307923; 16627869; 17478428
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.049 15.8 948 987
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+ C ++ kd  +++ C Hvf+++C+  ++      + ++ +CP C+
   Q: 948  CPCCNTRKKD-AVLTKCFHVFCFECVrGRY------EARQRKCPKCN 987
           9***999999.888************9999......**********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Protein Sequence
(Fasta)
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA 60
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045732|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCATCTCGCC GCTCTTCCGT GCCGCGAGGC GCCCCGGGCT CCCGCCGCCT AGGTTCCAGG 60
ACAGCCAGCG CTCGGTCGGC GGCTACCAAG GCCGGGCCCG TTCGCCTCGC TCCGGCCAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045732|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0043679--C:axon terminus
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0033503--C:HULC complex
GO:0016020--C:membrane
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0003730--F:mRNA 3'-UTR binding
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0043434--P:response to peptide hormone
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:9810
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001027 Aegilops tauschii 29.24 1.00e-12 68.20
IUUC-Aml-002295 Ailuropoda melanoleuca 96.70 0.00e+00 1712.00
IUUC-Atr-002836 Amborella trichopoda 31.12 9.00e-27 115.00
IUUC-Aca-004850 Anolis carolinensis 76.32 0.00e+00 680.00
IUUC-Aly-006055 Arabidopsis lyrata 27.90 1.00e-29 125.00
IUUC-Ath-007462 Arabidopsis thaliana 29.21 9.00e-30 125.00
IUUC-Ang-009601 Aspergillus niger 26.57 1.00e-16 82.00
IUUC-Ame-011745 Astyanax mexicanus 81.79 4.00e-152 532.00
IUUC-Bgr-012245 Blumeria graminis 23.91 5.00e-10 60.10
IUUC-Bta-013173 Bos taurus 95.60 0.00e+00 1687.00
IUUC-Bdi-014799 Brachypodium distachyon 29.20 1.00e-31 132.00
IUUC-Bol-015421 Brassica oleracea 29.20 2.00e-28 121.00
IUUC-Bra-016804 Brassica rapa 29.32 8.00e-35 142.00
IUUC-Cja-019042 Callithrix jacchus 96.80 0.00e+00 1687.00
IUUC-Cfa-020318 Canis familiaris 96.40 0.00e+00 1706.00
IUUC-Cpo-021539 Cavia porcellus 95.20 0.00e+00 1693.00
IUUC-Cre-022940 Chlamydomonas reinhardtii 37.93 1.00e-08 55.50
IUUC-Csa-024051 Chlorocebus sabaeus 98.30 0.00e+00 1669.00
IUUC-Cin-025174 Ciona intestinalis 62.28 5.00e-109 389.00
IUUC-Csv-025830 Ciona savignyi 54.79 5.00e-97 349.00
IUUC-Cgl-026569 Colletotrichum gloeosporioides 40.38 2.00e-09 58.20
IUUC-Cne-026878 Cryptococcus neoformans 26.57 1.00e-15 79.00
IUUC-Dre-028171 Danio rerio 80.95 2.00e-153 536.00
IUUC-Dno-028892 Dasypus novemcinctus 95.20 0.00e+00 1645.00
IUUC-Dor-030268 Dipodomys ordii 93.49 0.00e+00 781.00
IUUC-Dme-032034 Drosophila melanogaster 42.91 0.00e+00 709.00
IUUC-Ete-032505 Echinops telfairi 91.18 0.00e+00 639.00
IUUC-Eca-033436 Equus caballus 96.60 0.00e+00 1741.00
IUUC-Eeu-035291 Erinaceus europaeus 90.11 0.00e+00 1297.00
IUUC-Fca-035720 Felis catus 95.90 0.00e+00 1707.00
IUUC-Fox-038017 Fusarium oxysporum 28.26 2.00e-10 61.20
IUUC-Fso-038414 Fusarium solani 25.91 3.00e-10 60.50
IUUC-Gmo-039269 Gadus morhua 80.41 2.00e-143 503.00
IUUC-Gac-041303 Gasterosteus aculeatus 66.33 1.00e-151 531.00
IUUC-Gma-042797 Glycine max 27.82 3.00e-36 147.00
IUUC-Ggo-045426 Gorilla gorilla 99.50 0.00e+00 1772.00
IUUC-Hvu-047689 Hordeum vulgare 28.37 3.00e-28 120.00
IUUC-Itr-048724 Ictidomys tridecemlineatus 96.10 0.00e+00 1689.00
IUUC-Kpa-049345 Komagataella pastoris 28.74 1.00e-10 61.60
IUUC-Lch-049429 Latimeria chalumnae 84.75 3.00e-162 565.00
IUUC-Lpe-051253 Leersia perrieri 31.86 2.00e-34 141.00
IUUC-Laf-054267 Loxodonta africana 95.50 0.00e+00 1695.00
IUUC-Mcc-055240 Macaca mulatta 98.30 0.00e+00 1672.00
IUUC-Meu-056750 Macropus eugenii 83.61 0.00e+00 1414.00
IUUC-Mor-057068 Magnaporthe oryzae 43.40 5.00e-12 66.60
IUUC-Mtr-057632 Medicago truncatula 28.57 4.00e-33 137.00
IUUC-Mla-059072 Melampsora laricipopulina 28.10 2.00e-26 114.00
IUUC-Mvi-060341 Microbotryum violaceum 29.59 5.00e-23 103.00
IUUC-Mmr-061177 Microcebus murinus 96.30 0.00e+00 1707.00
IUUC-Mdo-062415 Monodelphis domestica 83.83 0.00e+00 1437.00
IUUC-Mmu-063981 Mus musculus 92.51 0.00e+00 1653.00
IUUC-Mac-065103 Musa acuminata 31.13 9.00e-43 169.00
IUUC-Mpu-066498 Mustela putorius furo 95.20 0.00e+00 1626.00
IUUC-Mlu-067242 Myotis lucifugus 94.61 0.00e+00 1671.00
IUUC-Nle-069320 Nomascus leucogenys 98.52 0.00e+00 884.00
IUUC-Opr-070286 Ochotona princeps 92.14 0.00e+00 1032.00
IUUC-Ont-071299 Oreochromis niloticus 80.56 3.00e-154 539.00
IUUC-Oan-073538 Ornithorhynchus anatinus 77.48 0.00e+00 632.00
IUUC-Ocu-073799 Oryctolagus cuniculus 95.80 0.00e+00 1694.00
IUUC-Oba-075000 Oryza barthii 28.75 3.00e-30 127.00
IUUC-Obr-076532 Oryza brachyantha 29.90 5.00e-33 136.00
IUUC-Ogl-077200 Oryza glaberrima 30.47 7.00e-33 135.00
IUUC-Ogu-078279 Oryza glumaepatula 28.75 2.00e-30 127.00
IUUC-Oin-079097 Oryza indica 30.47 6.00e-33 136.00
IUUC-Olo-080612 Oryza longistaminata 53.33 4.00e-15 77.40
IUUC-Ome-081304 Oryza meridionalis 30.08 1.00e-31 132.00
IUUC-Oni-082162 Oryza nivara 28.75 2.00e-30 127.00
IUUC-Opu-083683 Oryza punctata 50.00 4.00e-16 80.50
IUUC-Oru-084382 Oryza rufipogon 28.75 2.00e-30 127.00
IUUC-Osa-085839 Oryza sativa 50.00 4.00e-16 80.10
IUUC-Ola-086435 Oryzias latipes 68.55 2.00e-156 546.00
IUUC-Oga-089016 Otolemur garnettii 89.77 0.00e+00 1573.00
IUUC-Oar-089589 Ovis aries 95.90 0.00e+00 1699.00
IUUC-Ptr-090530 Pan troglodytes 99.28 0.00e+00 1379.00
IUUC-Pan-092502 Papio anubis 98.30 0.00e+00 1676.00
IUUC-Psi-093155 Pelodiscus sinensis 72.20 2.00e-142 499.00
IUUC-Pno-095079 Phaeosphaeria nodorum 27.06 2.00e-13 71.20
IUUC-Ppa-095735 Physcomitrella patens 33.88 3.00e-42 167.00
IUUC-Pfo-097527 Poecilia formosa 53.15 0.00e+00 755.00
IUUC-Pab-098619 Pongo abelii 99.00 0.00e+00 1759.00
IUUC-Pop-099376 Populus trichocarpa 29.71 1.00e-35 145.00
IUUC-Pca-100544 Procavia capensis 94.51 0.00e+00 1677.00
IUUC-Ppe-102065 Prunus persica 29.39 2.00e-31 131.00
IUUC-Pva-102479 Pteropus vampyrus 96.35 0.00e+00 1409.00
IUUC-Pgr-103536 Puccinia graminis 28.25 8.00e-22 99.40
IUUC-Ptt-104014 Puccinia triticina 26.98 4.00e-05 43.90
IUUC-Pte-104415 Pyrenophora teres 32.43 3.00e-13 70.90
IUUC-Pyt-104762 Pyrenophora triticirepentis 29.90 2.00e-13 71.20
IUUC-Rno-105165 Rattus norvegicus 92.51 0.00e+00 1629.00
IUUC-Sce-106384 Saccharomyces cerevisiae 24.25 5.00e-16 79.70
IUUC-Sha-107602 Sarcophilus harrisii 85.83 0.00e+00 1474.00
IUUC-Ssl-108546 Sclerotinia sclerotiorum 37.74 2.00e-08 54.70
IUUC-Smo-109550 Selaginella moellendorffii 29.92 9.00e-39 155.00
IUUC-Sit-109889 Setaria italica 29.81 4.00e-32 133.00
IUUC-Sly-111490 Solanum lycopersicum 32.74 9.00e-42 165.00
IUUC-Sar-113755 Sorex araneus 93.16 0.00e+00 1338.00
IUUC-Sbi-114734 Sorghum bicolor 31.33 4.00e-24 104.00
IUUC-Sre-115087 Sporisorium reilianum 24.91 3.00e-16 80.90
IUUC-Ssc-116134 Sus scrofa 94.71 0.00e+00 1700.00
IUUC-Tru-117867 Takifugu rubripes 80.56 3.00e-154 539.00
IUUC-Tsy-119065 Tarsius syrichta 91.95 0.00e+00 1478.00
IUUC-Tni-120802 Tetraodon nigroviridis 63.87 0.00e+00 1008.00
IUUC-Tca-121060 Theobroma cacao 32.78 1.00e-39 158.00
IUUC-Tre-122150 Trichoderma reesei 39.62 4.00e-10 60.50
IUUC-Tvi-122431 Trichoderma virens 39.62 4.00e-10 60.10
IUUC-Tae-124308 Triticum aestivum 30.11 1.00e-31 132.00
IUUC-Tur-126160 Triticum urartu 51.56 5.00e-16 80.10
IUUC-Tme-127177 Tuber melanosporum 22.91 2.00e-12 68.20
IUUC-Tbe-127597 Tupaia belangeri 87.92 0.00e+00 1062.00
IUUC-Ttr-128303 Tursiops truncatus 95.22 0.00e+00 1645.00
IUUC-Uma-129488 Ustilago maydis 27.68 8.00e-19 89.40
IUUC-Vda-129815 Verticillium dahliae 42.55 2.00e-09 58.20
IUUC-Vvi-131316 Vitis vinifera 31.02 3.00e-35 144.00
IUUC-Xtr-132906 Xenopus tropicalis 68.66 0.00e+00 640.00
IUUC-Xma-133607 Xiphophorus maculatus 61.90 5.00e-153 535.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved