iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000002041.1	ENSSHAT00000002324.1	ENSSHAP00000002300.1
ENSSHAG00000002041.1	ENSSHAT00000002325.1	ENSSHAP00000002301.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.50e-22	76.7	369	398
UBD/Beta-Prp	2.70e-44	151.7	451	722

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H+++v++l+   d tl++ G++D  + +W 
   Q: 369  HEGGVFGLCVlRDgTLVSGGGRDRRVVLWG 398
           9********888846555588********6 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseD.rtikvwdlstgkcvhtlkghed 95
            h++ +  ++ +p++s+++t ++d+ + +w++++ + ++s    e++ ++  f+p+g++l+ g    r + + d +t + v + +  ++
   Q: 451  GHTEELWGLAAHPSRSQFVTCGQDKQVHLWSADSHQPIWSK-IIEDPARSAGFHPSGSVLAVGTVTgRWLLL-DTETHDLVAIHTDGNE 537
           23334444666666677777777777777766665554443.223345666666666655544433144433.777************* PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           ++  +sfsp+g +l++Gshd+ + v+ +++g    +     sgh+++++++ + +d++++v+ s D  +  Wd                
   Q: 538  QISVVSFSPDGAFLAVGSHDNLVYVYSVSEGGRKVArlgKCSGHSSFITHLDWAEDSSCFVTNSGDYEILYWDPatckqitsadmvrnv 626
           ******************************99999889999***************************************999999999 PP
   S: 167  ..ktgkllrtl.......tgghtdsvyslsfdsngkelvsgsldgtvklwdlq...tgecvrtlnghtdnvksvrfs.pnderlvsgss 242
             +t++++  +       +g +  +++ ++ +++g+ l+s+++ g+v l+ +         +++ gh++ v+ v+f+ +++  l  g++
   Q: 627  ewATATCVLGFgvfgiwsEGVDGTDINAVARSHEGTLLASADDFGKVHLFAYPcshPRAPSHKYGGHSSHVTNVAFLwDDSAALSAGGK 715
           99999999999*******999****************************999866544459***************967777777778* PP
   S: 243  DgsiriW 249
           D s+  W
   Q: 716  DTSVLQW 722
           ****999 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

VCQLLKGFPS RSSVNGVLTP RRPGGYATSP SSPKKEATSG RRIDGGGGEG KGGSPGRREG 60
TKRQEEVRRG KPGGGGARGK GGSKTKEVIF SLEEGSVKMY LRGRPVPMLI PDSLAPTYSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATGCCAGC TCCTGAAAGG CTTCCCCTCC CGATCCTCGG TGAATGGCGT GCTGACCCCC 60
AGGCGCCCTG GGGGCTACGC CACCTCGCCC TCCTCCCCCA AGAAGGAAGC GACCTCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR005108--HELP
IPR023302--Pept_S9A_N
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0031115--P:negative regulation of microtubule polymerization
GO:0010968--P:regulation of microtubule nucleation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002155	Ailuropoda melanoleuca	83.36	0.00e+00	1236.00
IUUC-Aca-005316	Anolis carolinensis	75.84	0.00e+00	1068.00
IUUC-Bta-013267	Bos taurus	82.97	0.00e+00	1237.00
IUUC-Cel-018623	Caenorhabditis elegans	30.39	5.00e-84	305.00
IUUC-Cja-019146	Callithrix jacchus	83.23	0.00e+00	1137.00
IUUC-Cfa-020267	Canis familiaris	83.91	0.00e+00	1247.00
IUUC-Dno-028961	Dasypus novemcinctus	81.66	0.00e+00	1177.00
IUUC-Eca-033785	Equus caballus	82.75	0.00e+00	1218.00
IUUC-Eeu-035302	Erinaceus europaeus	87.23	0.00e+00	673.00
IUUC-Fca-036170	Felis catus	81.67	0.00e+00	1222.00
IUUC-Ggo-044669	Gorilla gorilla	82.03	0.00e+00	1205.00
IUUC-Hsa-046141	Homo sapiens	83.59	0.00e+00	1247.00
IUUC-Itr-048788	Ictidomys tridecemlineatus	82.44	0.00e+00	1224.00
IUUC-Laf-054137	Loxodonta africana	84.14	0.00e+00	1105.00
IUUC-Mcc-055780	Macaca mulatta	88.17	0.00e+00	1110.00
IUUC-Meu-056664	Macropus eugenii	92.04	0.00e+00	1214.00
IUUC-Mmr-060853	Microcebus murinus	82.90	0.00e+00	1236.00
IUUC-Mdo-062224	Monodelphis domestica	91.11	0.00e+00	1176.00
IUUC-Mmu-063860	Mus musculus	82.87	0.00e+00	1236.00
IUUC-Mpu-066043	Mustela putorius furo	83.43	0.00e+00	1240.00
IUUC-Mlu-067125	Myotis lucifugus	64.35	0.00e+00	858.00
IUUC-Nle-069618	Nomascus leucogenys	74.55	0.00e+00	1070.00
IUUC-Opr-070228	Ochotona princeps	80.50	0.00e+00	1057.00
IUUC-Oga-088048	Otolemur garnettii	80.61	0.00e+00	1184.00
IUUC-Oar-089907	Ovis aries	87.88	0.00e+00	1162.00
IUUC-Pan-092082	Papio anubis	83.08	0.00e+00	1235.00
IUUC-Pab-097619	Pongo abelii	88.61	0.00e+00	1196.00
IUUC-Pca-101070	Procavia capensis	77.54	0.00e+00	1009.00
IUUC-Pva-102957	Pteropus vampyrus	83.75	0.00e+00	1117.00
IUUC-Rno-105074	Rattus norvegicus	87.34	0.00e+00	1160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence