iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069244

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01077388

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000010045.2	ENSNLET00000012882.1	ENSNLEP00000012284.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-136	455.1	531	863

Active Site

Position(s)	Description	Evidence
832	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d++ lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 531  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYRLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 618
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ ++e
   Q: 619  GFSLPFYKCILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMLAE 704
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 705  WRMSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQITWFWQFVKEIDNEKRMRLLQFV 792
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 793  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 863
           *********************************************************************96 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCTAAC TCGCTCTAGT AGCTGTGGTC GAGGCTCGGG ACCGGCTGCC ATCTTAGTCT 60
AGGGACTGAG GAGTCGCCGC CGCCCCGAGT CCCGGTAAAC ACCCGTGGGC GAACGCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nle:100599625

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	96.47	0.00e+00	1598.00
IUUC-Apl-003752	Anas platyrhynchos	84.06	0.00e+00	1446.00
IUUC-Aca-005338	Anolis carolinensis	81.79	0.00e+00	1425.00
IUUC-Ago-007742	Ashbya gossypii	48.88	1.00e-162	566.00
IUUC-Ame-010601	Astyanax mexicanus	87.22	0.00e+00	1112.00
IUUC-Bta-012782	Bos taurus	95.83	0.00e+00	1576.00
IUUC-Bci-013785	Botrytis cinerea	46.92	3.00e-152	532.00
IUUC-Cja-018899	Callithrix jacchus	92.92	0.00e+00	1558.00
IUUC-Cfa-020648	Canis familiaris	95.19	0.00e+00	1561.00
IUUC-Cpo-022073	Cavia porcellus	96.99	0.00e+00	1636.00
IUUC-Csa-023252	Chlorocebus sabaeus	97.22	0.00e+00	1644.00
IUUC-Cho-024695	Choloepus hoffmanni	89.50	0.00e+00	1592.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.54	2.00e-155	542.00
IUUC-Cne-026849	Cryptococcus neoformans	47.63	2.00e-158	552.00
IUUC-Dre-028451	Danio rerio	74.89	0.00e+00	1289.00
IUUC-Dno-029884	Dasypus novemcinctus	96.18	0.00e+00	1645.00
IUUC-Dse-031241	Dothistroma septosporum	47.55	5.00e-156	545.00
IUUC-Eca-033793	Equus caballus	96.88	0.00e+00	1622.00
IUUC-Eeu-034716	Erinaceus europaeus	92.14	0.00e+00	879.00
IUUC-Fca-035605	Felis catus	96.24	0.00e+00	1625.00
IUUC-Fal-037126	Ficedula albicollis	82.03	0.00e+00	1437.00
IUUC-Fso-038393	Fusarium solani	47.21	4.00e-154	538.00
IUUC-Gmo-038596	Gadus morhua	80.03	0.00e+00	1004.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.86	2.00e-154	539.00
IUUC-Gga-040832	Gallus gallus	84.00	0.00e+00	1458.00
IUUC-Gac-041658	Gasterosteus aculeatus	86.32	0.00e+00	1114.00
IUUC-Ggo-044535	Gorilla gorilla	94.44	0.00e+00	1609.00
IUUC-Hsa-046564	Homo sapiens	93.81	0.00e+00	1637.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	95.72	0.00e+00	1575.00
IUUC-Kpa-049273	Komagataella pastoris	49.23	3.00e-163	568.00
IUUC-Lch-050454	Latimeria chalumnae	91.61	0.00e+00	1155.00
IUUC-Loc-052647	Lepisosteus oculatus	73.82	0.00e+00	1343.00
IUUC-Laf-054383	Loxodonta africana	96.99	0.00e+00	1640.00
IUUC-Mcc-055532	Macaca mulatta	97.45	0.00e+00	1646.00
IUUC-Mor-057097	Magnaporthe oryzae	47.44	3.00e-155	542.00
IUUC-Mga-059661	Meleagris gallopavo	83.88	0.00e+00	1446.00
IUUC-Mmr-061135	Microcebus murinus	97.11	0.00e+00	1653.00
IUUC-Mdo-062505	Monodelphis domestica	86.67	0.00e+00	1491.00
IUUC-Mmu-063375	Mus musculus	95.14	0.00e+00	1592.00
IUUC-Mpu-066203	Mustela putorius furo	96.82	0.00e+00	1600.00
IUUC-Mlu-067837	Myotis lucifugus	96.30	0.00e+00	1617.00
IUUC-Opr-070585	Ochotona princeps	90.28	0.00e+00	1570.00
IUUC-Ont-071798	Oreochromis niloticus	87.27	0.00e+00	1135.00
IUUC-Ocu-074298	Oryctolagus cuniculus	97.22	0.00e+00	1629.00
IUUC-Ola-086526	Oryzias latipes	68.68	0.00e+00	1293.00
IUUC-Oga-088167	Otolemur garnettii	89.85	0.00e+00	1499.00
IUUC-Oar-090316	Ovis aries	79.76	0.00e+00	1193.00
IUUC-Ptr-090819	Pan troglodytes	93.03	0.00e+00	1596.00
IUUC-Pan-092454	Papio anubis	97.45	0.00e+00	1646.00
IUUC-Psi-093319	Pelodiscus sinensis	81.63	0.00e+00	1414.00
IUUC-Pfo-097346	Poecilia formosa	83.86	0.00e+00	1100.00
IUUC-Pab-097580	Pongo abelii	87.07	0.00e+00	1476.00
IUUC-Pca-100923	Procavia capensis	78.94	0.00e+00	1347.00
IUUC-Pva-103209	Pteropus vampyrus	95.14	0.00e+00	1559.00
IUUC-Rno-104924	Rattus norvegicus	94.68	0.00e+00	1590.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.97	8.00e-162	563.00
IUUC-Sha-107175	Sarcophilus harrisii	87.83	0.00e+00	1496.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	46.62	1.00e-159	556.00
IUUC-Sar-113761	Sorex araneus	86.04	0.00e+00	1481.00
IUUC-Tgu-116632	Taeniopygia guttata	80.09	0.00e+00	1317.00
IUUC-Tru-118442	Takifugu rubripes	88.06	0.00e+00	1108.00
IUUC-Tsy-119198	Tarsius syrichta	90.39	0.00e+00	1518.00
IUUC-Tni-120168	Tetraodon nigroviridis	85.99	0.00e+00	1050.00
IUUC-Tre-122203	Trichoderma reesei	46.03	1.00e-149	523.00
IUUC-Tbe-127756	Tupaia belangeri	77.46	0.00e+00	1294.00
IUUC-Ttr-128504	Tursiops truncatus	90.56	0.00e+00	1173.00
IUUC-Vda-129753	Verticillium dahliae	46.94	8.00e-155	540.00
IUUC-Vpa-130103	Vicugna pacos	82.01	0.00e+00	1373.00
IUUC-Xtr-132885	Xenopus tropicalis	75.52	0.00e+00	1365.00
IUUC-Xma-133796	Xiphophorus maculatus	73.73	0.00e+00	1290.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence