iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133796

Ensembl Protein ID

ENSXMAP00000004671.1

UniProt Accession

M3ZR28; M3ZR28_XIPMA

Genbank Protein ID

ENSXMAP00000004671

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGAJ01023011

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000004641.1	ENSXMAT00000004676.1	ENSXMAP00000004671.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-135	451.0	547	879

Active Site

Position(s)	Description	Evidence
848	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d++ lq+np+s + np+hlk+F+f+Gr++++al++g+++d+
   Q: 547  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYGLQINPASDI-NPDHLKYFKFIGRFIAMALFHGKFIDT 634
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l+l dle++dpe+y+sl++ik+n   diee+gl++ fsv++e lge++++eLk+gG +i+Vt+eNkeeY+klv+e
   Q: 635  GFSLPFYKRMLNKPLTLIDLESIDPEFYNSLMWIKDN---DIEECGLEMFFSVDKEMLGEISTHELKEGGGDIQVTEENKEEYIKLVAE 720
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++e+d+ d++++t y++ yt++s++i wFw+ ++e+++e+r ++LqFv
   Q: 721  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQELDLGDWQNNTIYRH-YTRTSKQIVWFWQLMKEMDNEKRMRLLQFV 808
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 809  TGTCRLPVGGFANLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLMFAIEETEGFGQ 879
           *********************************************************************96 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MASGVAKSST SNGYPPKAQL QITVLSAKLK ENKKNWFAPS PYVEVTVDGQ SKKTEKCNNT 60
HSPKWKQPLT VIVTPFSKLV FRVWSHQTLK ADVFLGMAML DITETLKSNN MKISDLVQSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGTCTAAC ATGCGCCCCA CCTTGTTTCG ATCACGTGAC GAGAGCTCAC GAAGATGGTG 60
GAAGTTTCTT CTTCCTCTGA GTGAGACACC CCGACAGAAA CCCAAACATC CAGTCGGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0048920--P:posterior lateral line neuromast primordium migration

KEGG

xma:102233519

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	73.33	0.00e+00	1269.00
IUUC-Apl-003752	Anas platyrhynchos	72.36	0.00e+00	1276.00
IUUC-Aca-005338	Anolis carolinensis	71.91	0.00e+00	1280.00
IUUC-Cfa-020648	Canis familiaris	71.97	0.00e+00	1235.00
IUUC-Cpo-022073	Cavia porcellus	73.56	0.00e+00	1280.00
IUUC-Csa-023252	Chlorocebus sabaeus	73.03	0.00e+00	1272.00
IUUC-Dre-028451	Danio rerio	77.61	0.00e+00	1340.00
IUUC-Eca-033793	Equus caballus	72.66	0.00e+00	1268.00
IUUC-Fca-035605	Felis catus	74.07	0.00e+00	1287.00
IUUC-Gga-040832	Gallus gallus	72.62	0.00e+00	1288.00
IUUC-Gac-041658	Gasterosteus aculeatus	82.09	0.00e+00	1372.00
IUUC-Ggo-044535	Gorilla gorilla	70.45	0.00e+00	1244.00
IUUC-Hsa-046564	Homo sapiens	68.47	0.00e+00	1211.00
IUUC-Laf-054383	Loxodonta africana	73.61	0.00e+00	1277.00
IUUC-Mcc-055532	Macaca mulatta	73.15	0.00e+00	1273.00
IUUC-Mga-059661	Meleagris gallopavo	72.06	0.00e+00	1276.00
IUUC-Mmr-061135	Microcebus murinus	72.52	0.00e+00	1285.00
IUUC-Mpu-066203	Mustela putorius furo	73.26	0.00e+00	1269.00
IUUC-Mlu-067837	Myotis lucifugus	73.03	0.00e+00	1273.00
IUUC-Nle-069244	Nomascus leucogenys	73.38	0.00e+00	1276.00
IUUC-Ont-071822	Oreochromis niloticus	78.64	0.00e+00	1451.00
IUUC-Ola-086526	Oryzias latipes	85.69	0.00e+00	1156.00
IUUC-Oga-088167	Otolemur garnettii	68.01	0.00e+00	1181.00
IUUC-Ptr-090819	Pan troglodytes	67.15	0.00e+00	1151.00
IUUC-Pan-092454	Papio anubis	73.15	0.00e+00	1273.00
IUUC-Psi-093319	Pelodiscus sinensis	69.55	0.00e+00	1224.00
IUUC-Pfo-097346	Poecilia formosa	97.39	0.00e+00	1589.00
IUUC-Pca-100923	Procavia capensis	64.28	0.00e+00	1037.00
IUUC-Pva-103209	Pteropus vampyrus	72.45	0.00e+00	1228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence