iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107187

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01165977

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015696.1	ENSSHAT00000018641.1	ENSSHAP00000018487.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.90e-07	29.9	324	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e+f +  ++l+C H f+  C++ w       +++  CP+Cr
   Q: 324  CIICSEHFIE-AVTLNCAHSFCSYCINEW------MKRKVECPICR 362
           ********99.899***************......**********8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

SLNGVWLNKE RLEPLKAYPI REGDQIQLGV PLENKENAEY EYEVVEEDWD KIHLCLALRN 60
NRAVVKCSRT KRKCSLEELD SPGAEGSSNS RTKVNKVSHY YEQSGKSCGK AEMSKEAPKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCTGAATG GTGTTTGGCT GAACAAAGAA CGCCTGGAAC CTTTAAAGGC TTATCCTATT 60
CGGGAGGGAG ACCAAATCCA GCTTGGAGTT CCACTAGAAA ATAAGGAGAA TGCAGAATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	66.34	1.00e-97	350.00
IUUC-Apl-003664	Anas platyrhynchos	82.61	1.00e-40	157.00
IUUC-Aca-005036	Anolis carolinensis	58.62	3.00e-84	305.00
IUUC-Ame-011537	Astyanax mexicanus	39.90	5.00e-57	215.00
IUUC-Bta-013297	Bos taurus	65.93	8.00e-91	327.00
IUUC-Cja-019201	Callithrix jacchus	65.76	1.00e-109	389.00
IUUC-Cfa-021041	Canis familiaris	68.15	3.00e-114	405.00
IUUC-Csa-024133	Chlorocebus sabaeus	66.34	2.00e-112	399.00
IUUC-Cho-024624	Choloepus hoffmanni	60.55	7.00e-86	310.00
IUUC-Dre-027918	Danio rerio	41.91	4.00e-54	205.00
IUUC-Dno-029774	Dasypus novemcinctus	69.38	1.00e-114	406.00
IUUC-Dor-030190	Dipodomys ordii	56.56	6.00e-70	258.00
IUUC-Ete-032301	Echinops telfairi	60.99	1.00e-102	366.00
IUUC-Eca-033607	Equus caballus	68.15	1.00e-102	366.00
IUUC-Eeu-034888	Erinaceus europaeus	68.79	4.00e-85	308.00
IUUC-Fca-036075	Felis catus	65.93	9.00e-110	390.00
IUUC-Fal-037569	Ficedula albicollis	66.09	1.00e-109	389.00
IUUC-Gmo-038588	Gadus morhua	37.14	2.00e-46	180.00
IUUC-Gga-040777	Gallus gallus	63.95	5.00e-103	367.00
IUUC-Gac-042463	Gasterosteus aculeatus	40.00	2.00e-37	150.00
IUUC-Ggo-045269	Gorilla gorilla	66.17	4.00e-112	398.00
IUUC-Hsa-046249	Homo sapiens	66.42	2.00e-106	379.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	65.78	4.00e-106	378.00
IUUC-Lch-049805	Latimeria chalumnae	49.03	9.00e-78	284.00
IUUC-Loc-052377	Lepisosteus oculatus	45.65	1.00e-61	230.00
IUUC-Mcc-055344	Macaca mulatta	66.42	2.00e-112	399.00
IUUC-Meu-055950	Macropus eugenii	88.03	2.00e-166	578.00
IUUC-Mla-059052	Melampsora laricipopulina	39.06	8.00e-11	60.10
IUUC-Mga-060049	Meleagris gallopavo	63.88	2.00e-101	362.00
IUUC-Mmr-061431	Microcebus murinus	67.08	8.00e-105	373.00
IUUC-Mdo-062016	Monodelphis domestica	90.00	4.00e-150	526.00
IUUC-Mmu-063235	Mus musculus	60.49	2.00e-108	385.00
IUUC-Mpu-066449	Mustela putorius furo	69.14	2.00e-117	415.00
IUUC-Mlu-067588	Myotis lucifugus	64.85	2.00e-96	346.00
IUUC-Nle-069192	Nomascus leucogenys	66.17	2.00e-111	395.00
IUUC-Opr-070300	Ochotona princeps	52.36	2.00e-75	276.00
IUUC-Ont-071998	Oreochromis niloticus	41.18	2.00e-39	157.00
IUUC-Oan-073610	Ornithorhynchus anatinus	70.00	1.00e-70	258.00
IUUC-Ocu-074603	Oryctolagus cuniculus	65.43	6.00e-102	364.00
IUUC-Ola-086681	Oryzias latipes	39.67	3.00e-51	195.00
IUUC-Oga-088183	Otolemur garnettii	65.93	1.00e-109	389.00
IUUC-Oar-090255	Ovis aries	62.86	6.00e-89	321.00
IUUC-Ptr-091029	Pan troglodytes	66.67	8.00e-112	397.00
IUUC-Pan-092241	Papio anubis	66.42	6.00e-113	400.00
IUUC-Psi-093506	Pelodiscus sinensis	66.34	5.00e-100	358.00
IUUC-Pma-094579	Petromyzon marinus	57.14	5.00e-27	115.00
IUUC-Pfo-097014	Poecilia formosa	40.52	6.00e-39	155.00
IUUC-Pab-098530	Pongo abelii	65.93	6.00e-111	394.00
IUUC-Pca-100939	Procavia capensis	55.06	5.00e-83	301.00
IUUC-Pva-103148	Pteropus vampyrus	59.51	6.00e-91	327.00
IUUC-Rno-105338	Rattus norvegicus	62.72	5.00e-112	397.00
IUUC-Sja-107948	Schizosaccharomyces japonicus	24.24	2.00e-10	60.10
IUUC-Sar-113356	Sorex araneus	53.96	2.00e-93	335.00
IUUC-Ssc-116290	Sus scrofa	66.00	1.00e-115	409.00
IUUC-Tru-117910	Takifugu rubripes	40.87	3.00e-40	159.00
IUUC-Tsy-119329	Tarsius syrichta	62.47	1.00e-96	346.00
IUUC-Tni-120521	Tetraodon nigroviridis	38.13	5.00e-40	158.00
IUUC-Ttr-128997	Tursiops truncatus	56.94	6.00e-98	350.00
IUUC-Vpa-130154	Vicugna pacos	61.79	3.00e-106	378.00
IUUC-Xtr-132805	Xenopus tropicalis	52.23	2.00e-76	279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence