iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066153

Ensembl Protein ID

ENSMPUP00000013245.1

UniProt Accession

M3YPI7; M3YPI7_MUSPF

Genbank Protein ID

ENSMPUP00000013245

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01006144

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000013344.1	ENSMPUT00000013457.1	ENSMPUP00000013245.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.90e-09	37.9	1108	1213
E3 activity/N-recognin/N-domain	1.10e-39	134.4	227	302
E3 activity/N-recognin/UBR-box	9.20e-32	109.4	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC......................................ledf........kdgplvlpCgHvfhadClqkw............ 29
           C++C                                      +           ++g+++++CgH++ha+C+q++            
   Q: 1108 CILCqeeqevkveskamvlaafvqrstvlsknrskfiqdpekY--DplfmhpdlSCGTHTGSCGHIMHAHCWQRYfdsvqakeqrrq 1192
           8888444444444444443333333333333333333333321..02344444455899**************************** PP
   S: 30   .....pglknssskefrCPlC 45
                + +++++++ef+CPlC
   Q: 1193 qrlrlHTSYDVENGEFLCPLC 1213
           ********************* PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++n++++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MASELEPEVQ AIDRSLLECS AEEIAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPFPQK 60
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTCGG AGCTGGAGCC CGAGGTGCAG GCCATCGACC GGAGTTTGCT GGAATGTTCG 60
GCTGAGGAGA TTGCAGGGGT GAGTGCCGGG ACCCGAGCGG GGACTTTCGG CCCTCGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.93	1.00e-22	103.00
IUUC-Aml-001876	Ailuropoda melanoleuca	86.96	0.00e+00	2801.00
IUUC-Atr-002501	Amborella trichopoda	28.67	7.00e-28	120.00
IUUC-Apl-003828	Anas platyrhynchos	87.51	0.00e+00	3071.00
IUUC-Aca-005189	Anolis carolinensis	85.99	0.00e+00	3057.00
IUUC-Aly-005901	Arabidopsis lyrata	32.39	3.00e-26	115.00
IUUC-Ath-007148	Arabidopsis thaliana	30.99	7.00e-25	110.00
IUUC-Ago-007946	Ashbya gossypii	22.58	2.00e-25	112.00
IUUC-Afl-008479	Aspergillus flavus	23.59	3.00e-47	185.00
IUUC-Afu-008929	Aspergillus fumigatus	24.60	1.00e-55	213.00
IUUC-Ani-009334	Aspergillus nidulans	24.49	5.00e-51	197.00
IUUC-Ang-009550	Aspergillus niger	24.32	2.00e-48	188.00
IUUC-Aor-010124	Aspergillus oryzae	23.59	3.00e-47	185.00
IUUC-Ame-011917	Astyanax mexicanus	73.98	0.00e+00	2504.00
IUUC-Bta-012768	Bos taurus	93.85	0.00e+00	3291.00
IUUC-Bci-013834	Botrytis cinerea	23.90	2.00e-32	135.00
IUUC-Bdi-014635	Brachypodium distachyon	26.09	1.00e-31	133.00
IUUC-Bol-015669	Brassica oleracea	31.45	1.00e-30	130.00
IUUC-Bra-017776	Brassica rapa	31.45	3.00e-31	132.00
IUUC-Cel-018476	Caenorhabditis elegans	31.28	5.00e-84	307.00
IUUC-Cja-019797	Callithrix jacchus	95.56	0.00e+00	2617.00
IUUC-Cfa-020950	Canis familiaris	98.63	0.00e+00	3437.00
IUUC-Cpo-022385	Cavia porcellus	92.54	0.00e+00	3269.00
IUUC-Csa-024082	Chlorocebus sabaeus	96.64	0.00e+00	3371.00
IUUC-Cho-025029	Choloepus hoffmanni	86.93	0.00e+00	2190.00
IUUC-Cin-025148	Ciona intestinalis	36.57	2.00e-138	486.00
IUUC-Csv-026296	Ciona savignyi	32.10	2.00e-21	96.30
IUUC-Cgl-026605	Colletotrichum gloeosporioides	24.05	5.00e-55	211.00
IUUC-Cne-026823	Cryptococcus neoformans	22.17	1.00e-38	156.00
IUUC-Dre-028343	Danio rerio	72.64	0.00e+00	2488.00
IUUC-Dno-030002	Dasypus novemcinctus	93.06	0.00e+00	1978.00
IUUC-Dor-030207	Dipodomys ordii	79.39	0.00e+00	1592.00
IUUC-Dse-031531	Dothistroma septosporum	23.88	2.00e-54	208.00
IUUC-Dme-031910	Drosophila melanogaster	34.74	0.00e+00	676.00
IUUC-Ete-033162	Echinops telfairi	84.79	0.00e+00	1385.00
IUUC-Eca-033454	Equus caballus	95.67	0.00e+00	3335.00
IUUC-Eeu-034783	Erinaceus europaeus	78.60	0.00e+00	1547.00
IUUC-Fca-036588	Felis catus	97.95	0.00e+00	3405.00
IUUC-Fal-036919	Ficedula albicollis	87.67	0.00e+00	3008.00
IUUC-Fox-037984	Fusarium oxysporum	25.30	6.00e-40	160.00
IUUC-Fso-038463	Fusarium solani	24.59	2.00e-44	176.00
IUUC-Gmo-039698	Gadus morhua	69.82	0.00e+00	1613.00
IUUC-Ggr-040070	Gaeumannomyces graminis	23.51	3.00e-45	178.00
IUUC-Gga-041123	Gallus gallus	88.84	0.00e+00	3125.00
IUUC-Gac-042622	Gasterosteus aculeatus	65.87	0.00e+00	2194.00
IUUC-Gma-043622	Glycine max	29.34	7.00e-27	117.00
IUUC-Ggo-045583	Gorilla gorilla	94.84	0.00e+00	3328.00
IUUC-Hsa-046343	Homo sapiens	95.38	0.00e+00	3327.00
IUUC-Hvu-047707	Hordeum vulgare	30.14	6.00e-23	103.00
IUUC-Kpa-049088	Komagataella pastoris	23.24	6.00e-46	180.00
IUUC-Lch-049649	Latimeria chalumnae	75.44	0.00e+00	2615.00
IUUC-Lpe-051516	Leersia perrieri	26.23	2.00e-32	135.00
IUUC-Loc-052818	Lepisosteus oculatus	76.10	0.00e+00	2652.00
IUUC-Lma-053059	Leptosphaeria maculans	23.39	5.00e-49	191.00
IUUC-Laf-054142	Loxodonta africana	93.28	0.00e+00	3285.00
IUUC-Mcc-055677	Macaca mulatta	96.24	0.00e+00	3344.00
IUUC-Meu-056204	Macropus eugenii	68.83	0.00e+00	739.00
IUUC-Mor-057051	Magnaporthe oryzae	23.88	1.00e-51	199.00
IUUC-Mpo-057372	Magnaporthe poae	25.22	4.00e-47	184.00
IUUC-Mtr-058538	Medicago truncatula	29.94	3.00e-29	125.00
IUUC-Mla-058963	Melampsora laricipopulina	25.15	1.00e-56	216.00
IUUC-Mga-059698	Meleagris gallopavo	89.08	0.00e+00	3098.00
IUUC-Mvi-060535	Microbotryum violaceum	25.06	2.00e-51	199.00
IUUC-Mmr-060901	Microcebus murinus	93.28	0.00e+00	3237.00
IUUC-Mdo-062014	Monodelphis domestica	91.91	0.00e+00	3237.00
IUUC-Mmu-063699	Mus musculus	89.69	0.00e+00	3150.00
IUUC-Mac-064773	Musa acuminata	31.10	1.00e-27	119.00
IUUC-Mlu-068151	Myotis lucifugus	94.42	0.00e+00	3286.00
IUUC-Nfi-068403	Neosartorya fischeri	23.97	6.00e-55	210.00
IUUC-Ncr-068864	Neurospora crassa	23.58	5.00e-43	171.00
IUUC-Nle-069529	Nomascus leucogenys	96.47	0.00e+00	3368.00
IUUC-Opr-071107	Ochotona princeps	88.57	0.00e+00	1359.00
IUUC-Ont-072189	Oreochromis niloticus	66.97	0.00e+00	2179.00
IUUC-Oan-072893	Ornithorhynchus anatinus	89.34	0.00e+00	3135.00
IUUC-Ocu-074082	Oryctolagus cuniculus	92.48	0.00e+00	3239.00
IUUC-Obr-076117	Oryza brachyantha	26.35	3.00e-28	122.00
IUUC-Ogl-077571	Oryza glaberrima	30.60	1.00e-21	100.00
IUUC-Ogu-078497	Oryza glumaepatula	23.18	1.00e-14	77.00
IUUC-Olo-081056	Oryza longistaminata	25.88	1.00e-17	86.30
IUUC-Ome-081738	Oryza meridionalis	23.17	6.00e-16	81.30
IUUC-Opu-083202	Oryza punctata	27.37	1.00e-28	123.00
IUUC-Osa-085336	Oryza sativa	27.89	1.00e-21	99.00
IUUC-Ola-087460	Oryzias latipes	65.02	0.00e+00	2158.00
IUUC-Oga-088432	Otolemur garnettii	93.85	0.00e+00	3307.00
IUUC-Oar-090206	Ovis aries	93.88	0.00e+00	3307.00
IUUC-Ptr-091180	Pan troglodytes	95.10	0.00e+00	3327.00
IUUC-Pan-092375	Papio anubis	96.30	0.00e+00	3364.00
IUUC-Psi-093049	Pelodiscus sinensis	88.33	0.00e+00	3076.00
IUUC-Pma-094152	Petromyzon marinus	47.69	0.00e+00	658.00
IUUC-Pno-094877	Phaeosphaeria nodorum	24.61	7.00e-33	137.00
IUUC-Ppa-095715	Physcomitrella patens	28.99	7.00e-24	107.00
IUUC-Pfo-096524	Poecilia formosa	63.54	0.00e+00	2045.00
IUUC-Pab-097989	Pongo abelii	94.53	0.00e+00	3277.00
IUUC-Pca-100207	Procavia capensis	80.53	0.00e+00	1263.00
IUUC-Ppe-101802	Prunus persica	29.66	1.00e-27	119.00
IUUC-Pva-102538	Pteropus vampyrus	94.89	0.00e+00	1242.00
IUUC-Pgr-103372	Puccinia graminis	24.86	7.00e-54	207.00
IUUC-Ptt-103878	Puccinia triticina	24.49	6.00e-50	193.00
IUUC-Rno-105567	Rattus norvegicus	89.69	0.00e+00	3094.00
IUUC-Sce-106272	Saccharomyces cerevisiae	21.02	5.00e-26	114.00
IUUC-Sha-106980	Sarcophilus harrisii	91.38	0.00e+00	3090.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.62	2.00e-48	188.00
IUUC-Spo-108183	Schizosaccharomyces pombe	24.80	2.00e-50	195.00
IUUC-Smo-108719	Selaginella moellendorffii	31.54	9.00e-31	130.00
IUUC-Sit-110716	Setaria italica	25.96	2.00e-32	135.00
IUUC-Sly-111286	Solanum lycopersicum	29.82	1.00e-27	119.00
IUUC-Sar-113332	Sorex araneus	87.50	0.00e+00	2206.00
IUUC-Sbi-114577	Sorghum bicolor	29.30	1.00e-31	133.00
IUUC-Sre-115045	Sporisorium reilianum	26.67	2.00e-45	179.00
IUUC-Ssc-115525	Sus scrofa	95.39	0.00e+00	2588.00
IUUC-Tgu-116943	Taeniopygia guttata	88.73	0.00e+00	3114.00
IUUC-Tru-117673	Takifugu rubripes	65.83	0.00e+00	2187.00
IUUC-Tsy-119032	Tarsius syrichta	93.36	0.00e+00	1847.00
IUUC-Tni-119987	Tetraodon nigroviridis	65.38	0.00e+00	2142.00
IUUC-Tca-121077	Theobroma cacao	32.70	2.00e-26	115.00
IUUC-Tre-122137	Trichoderma reesei	24.80	9.00e-60	226.00
IUUC-Tvi-122272	Trichoderma virens	23.05	2.00e-55	212.00
IUUC-Tae-125358	Triticum aestivum	30.14	2.00e-22	102.00
IUUC-Tur-126562	Triticum urartu	31.02	2.00e-29	124.00
IUUC-Tme-127156	Tuber melanosporum	24.08	1.00e-52	202.00
IUUC-Tbe-128103	Tupaia belangeri	88.17	0.00e+00	1256.00
IUUC-Ttr-128253	Tursiops truncatus	89.91	0.00e+00	3099.00
IUUC-Uma-129344	Ustilago maydis	26.88	4.00e-51	197.00
IUUC-Vda-129778	Verticillium dahliae	24.51	1.00e-47	186.00
IUUC-Vpa-130540	Vicugna pacos	91.07	0.00e+00	2971.00
IUUC-Vvi-131290	Vitis vinifera	30.77	3.00e-29	124.00
IUUC-Xtr-132690	Xenopus tropicalis	80.65	0.00e+00	2848.00
IUUC-Xma-133748	Xiphophorus maculatus	64.61	0.00e+00	2022.00
IUUC-Yli-134662	Yarrowia lipolytica	23.65	1.00e-30	129.00
IUUC-Zma-135553	Zea mays	23.98	9.00e-18	87.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence