iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059756

Ensembl Protein ID

ENSMGAP00000004050.2

UniProt Accession

G1MYL5; G1MYL5_MELGA

Protein Name

Histone-lysine N-methyltransferase

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000004240.2	ENSMGAT00000004761.2	ENSMGAP00000004050.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.60e-16	58.0	1417	1457

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++Ce C  +fH +Cl+++    +p+ + w+C++C+
   Q: 1417 WCFVCSEGGS----LLCCESCPAAFHRECLNIE----MPEGS-WYCNDCK 1457
           8*********....*******************....99998.******8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

PKIRAKKKPT PVKYEVGDLV WAKFNRRPWW PCTICHDPVL DCHSKMKVSN RRPYREYYVD 60
ALGEPSEKAW VAGKAIVLFE GRHQFEELPV LRRRGKQKEK GYKHKVPQRF MAKWEVSVGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAAGATCC GAGCCAAGAA GAAACCTACT CCAGTGAAGT ATGAAGTTGG GGATCTTGTT 60
TGGGCCAAGT TCAACAGACG CCCGTGGTGG CCATGCACAA TTTGTCATGA CCCAGTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000229	Aegilops tauschii	58.33	1.00e-04	42.70
IUUC-Aml-001795	Ailuropoda melanoleuca	56.90	0.00e+00	2251.00
IUUC-Apl-003953	Anas platyrhynchos	88.82	0.00e+00	3836.00
IUUC-Aca-005339	Anolis carolinensis	55.37	0.00e+00	1971.00
IUUC-Bta-012966	Bos taurus	56.87	0.00e+00	2322.00
IUUC-Bdi-014781	Brachypodium distachyon	28.64	6.00e-14	72.40
IUUC-Bol-016001	Brassica oleracea	28.57	6.00e-17	83.20
IUUC-Bra-017864	Brassica rapa	28.02	9.00e-16	79.70
IUUC-Cja-018780	Callithrix jacchus	56.50	0.00e+00	2279.00
IUUC-Cfa-020975	Canis familiaris	57.17	0.00e+00	2287.00
IUUC-Cpo-021331	Cavia porcellus	64.02	0.00e+00	1687.00
IUUC-Csa-024226	Chlorocebus sabaeus	56.27	0.00e+00	2255.00
IUUC-Cho-024464	Choloepus hoffmanni	60.18	3.00e-150	526.00
IUUC-Csv-026298	Ciona savignyi	38.54	8.00e-57	214.00
IUUC-Dre-027488	Danio rerio	77.68	0.00e+00	1247.00
IUUC-Dno-029230	Dasypus novemcinctus	55.20	0.00e+00	2200.00
IUUC-Dor-031016	Dipodomys ordii	63.34	0.00e+00	1071.00
IUUC-Dme-032193	Drosophila melanogaster	36.22	2.00e-122	433.00
IUUC-Eca-033591	Equus caballus	56.91	0.00e+00	2302.00
IUUC-Fca-035791	Felis catus	57.07	0.00e+00	2314.00
IUUC-Fal-037378	Ficedula albicollis	82.41	0.00e+00	3185.00
IUUC-Gmo-038919	Gadus morhua	71.41	0.00e+00	946.00
IUUC-Gga-040881	Gallus gallus	88.27	0.00e+00	3684.00
IUUC-Gac-041378	Gasterosteus aculeatus	78.03	0.00e+00	1063.00
IUUC-Hsa-046436	Homo sapiens	56.97	0.00e+00	2271.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	57.44	0.00e+00	2293.00
IUUC-Lch-049684	Latimeria chalumnae	55.06	0.00e+00	1412.00
IUUC-Laf-054046	Loxodonta africana	57.86	0.00e+00	2257.00
IUUC-Mcc-055593	Macaca mulatta	56.41	0.00e+00	2263.00
IUUC-Mmr-061182	Microcebus murinus	57.10	0.00e+00	2304.00
IUUC-Mdo-061984	Monodelphis domestica	57.65	0.00e+00	2216.00
IUUC-Mmu-063605	Mus musculus	55.28	0.00e+00	2236.00
IUUC-Mpu-066446	Mustela putorius furo	56.67	0.00e+00	2297.00
IUUC-Mlu-067261	Myotis lucifugus	56.39	0.00e+00	2273.00
IUUC-Nle-069818	Nomascus leucogenys	57.25	0.00e+00	2272.00
IUUC-Opr-070842	Ochotona princeps	60.61	0.00e+00	1461.00
IUUC-Ont-072448	Oreochromis niloticus	75.22	0.00e+00	1152.00
IUUC-Oan-073496	Ornithorhynchus anatinus	79.25	0.00e+00	1589.00
IUUC-Ocu-074918	Oryctolagus cuniculus	57.27	0.00e+00	2322.00
IUUC-Obr-076753	Oryza brachyantha	54.84	7.00e-08	53.50
IUUC-Ola-087518	Oryzias latipes	76.38	0.00e+00	1060.00
IUUC-Oga-088743	Otolemur garnettii	56.97	0.00e+00	2214.00
IUUC-Oar-090265	Ovis aries	57.08	0.00e+00	2315.00
IUUC-Ptr-090521	Pan troglodytes	56.78	0.00e+00	2279.00
IUUC-Psi-093245	Pelodiscus sinensis	69.68	0.00e+00	2476.00
IUUC-Pfo-096066	Poecilia formosa	61.43	0.00e+00	1206.00
IUUC-Pab-098644	Pongo abelii	56.32	0.00e+00	2249.00
IUUC-Pva-103094	Pteropus vampyrus	69.84	0.00e+00	1198.00
IUUC-Rno-105803	Rattus norvegicus	55.11	0.00e+00	2239.00
IUUC-Sha-107278	Sarcophilus harrisii	58.24	0.00e+00	2312.00
IUUC-Sar-113402	Sorex araneus	86.25	0.00e+00	1060.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	8.00e-13	65.50
IUUC-Ssc-116193	Sus scrofa	57.61	0.00e+00	2290.00
IUUC-Tgu-116532	Taeniopygia guttata	98.33	0.00e+00	1342.00
IUUC-Tru-117988	Takifugu rubripes	77.21	0.00e+00	1190.00
IUUC-Tsy-118830	Tarsius syrichta	56.63	0.00e+00	2165.00
IUUC-Tae-124697	Triticum aestivum	58.33	9.00e-05	43.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence