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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046397
Ensembl Protein ID ENSP00000385319.2
UniProt Accession Q96JB3; Q504T6; Q96KR3; Q9NSM9; Q9UPX9; HIC2_HUMAN
Genbank Protein ID CAC70715.1; AAK72951.1; BAA82972.2; CAG30263.1; AAH94787.1; CAB82344.1
Protein Name Hypermethylated in cancer 2 protein; HIC1-related gene on chromosome 22 protein; Hic-3; Zinc finger and BTB domain-containing protein 30
Genbank Nucleotide ID AJ313204; AF349035; AB028943; CR456377; AP000557; AL162003
Gene Name HIC2; HRG22; KIAA1020; ZBTB30
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000169635.9 ENST00000407464.6 ENSP00000385319.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteJASPARcircBase
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.80e-11 45.9 46 105
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkl 65
           +Dvi+ v+++ f+ahk vLaasS +F++l l+        + ++++ d v+ +vf+++l+F+Ytgkl
   Q: 46   CDVIIMVENSIFRAHKNVLAASSIYFKSLVLH-------DNLINLDtDmVSSTVFQQILDFIYTGKL 105
           8*****************************99.......5789999889****************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Self-associates. Interacts with HIC1.
 Self-associates. Interacts with HIC1.
Protein Sequence
(Fasta)
MVSGPLALRW CAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII MVENSIFRAH 60
KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PAEPNFSTLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046397|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAGCGGCG CTCGGGGCGC GCTAGGCGGG GAGCCGAGCC GGGCTGGCGG CAGGCGGACG 60
GGGCGGGCGC GTGCGGCGCG AGCCGGGCGC TGAGGACAAG GGCCGCTGGT AGGGCCGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046397|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008022--F:protein C-terminus binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:23119
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004217 Anas platyrhynchos 65.40 0.00e+00 675.00
IUUC-Ame-010754 Astyanax mexicanus 66.42 1.00e-86 313.00
IUUC-Bta-013162 Bos taurus 82.50 0.00e+00 830.00
IUUC-Cfa-020537 Canis familiaris 93.20 0.00e+00 973.00
IUUC-Cpo-021843 Cavia porcellus 91.75 0.00e+00 968.00
IUUC-Csa-023171 Chlorocebus sabaeus 98.21 0.00e+00 940.00
IUUC-Dre-027672 Danio rerio 55.89 5.00e-154 537.00
IUUC-Dno-029125 Dasypus novemcinctus 87.18 0.00e+00 816.00
IUUC-Dor-030484 Dipodomys ordii 88.13 1.00e-123 435.00
IUUC-Ete-033019 Echinops telfairi 79.20 1.00e-127 450.00
IUUC-Eca-033737 Equus caballus 93.37 0.00e+00 915.00
IUUC-Eeu-035190 Erinaceus europaeus 84.40 9.00e-164 569.00
IUUC-Fca-036031 Felis catus 91.91 0.00e+00 916.00
IUUC-Fal-037342 Ficedula albicollis 63.07 0.00e+00 681.00
IUUC-Gmo-039209 Gadus morhua 52.43 6.00e-145 508.00
IUUC-Gga-040433 Gallus gallus 62.44 0.00e+00 671.00
IUUC-Gac-041588 Gasterosteus aculeatus 52.45 4.00e-147 514.00
IUUC-Ggo-045081 Gorilla gorilla 99.66 0.00e+00 876.00
IUUC-Itr-048738 Ictidomys tridecemlineatus 90.78 0.00e+00 922.00
IUUC-Loc-052129 Lepisosteus oculatus 60.23 0.00e+00 648.00
IUUC-Mcc-055370 Macaca mulatta 98.36 0.00e+00 932.00
IUUC-Mga-059911 Meleagris gallopavo 62.66 0.00e+00 646.00
IUUC-Mmr-060683 Microcebus murinus 92.68 0.00e+00 916.00
IUUC-Mdo-062271 Monodelphis domestica 70.45 0.00e+00 709.00
IUUC-Mmu-063688 Mus musculus 85.32 0.00e+00 885.00
IUUC-Mpu-066134 Mustela putorius furo 92.88 0.00e+00 908.00
IUUC-Mlu-067531 Myotis lucifugus 92.23 0.00e+00 952.00
IUUC-Nle-069726 Nomascus leucogenys 90.89 0.00e+00 837.00
IUUC-Opr-071056 Ochotona princeps 82.19 2.00e-172 599.00
IUUC-Ont-071390 Oreochromis niloticus 54.56 4.00e-150 525.00
IUUC-Ocu-073887 Oryctolagus cuniculus 85.53 0.00e+00 818.00
IUUC-Oga-088655 Otolemur garnettii 93.50 0.00e+00 939.00
IUUC-Oar-089691 Ovis aries 76.58 1.00e-41 160.00
IUUC-Ptr-090786 Pan troglodytes 99.02 0.00e+00 921.00
IUUC-Pan-092901 Papio anubis 98.37 0.00e+00 915.00
IUUC-Psi-093684 Pelodiscus sinensis 66.72 0.00e+00 709.00
IUUC-Pfo-096241 Poecilia formosa 54.15 1.00e-98 353.00
IUUC-Pab-098162 Pongo abelii 98.86 0.00e+00 913.00
IUUC-Pca-101051 Procavia capensis 89.76 0.00e+00 874.00
IUUC-Rno-105690 Rattus norvegicus 85.07 0.00e+00 890.00
IUUC-Ssc-116215 Sus scrofa 87.99 0.00e+00 894.00
IUUC-Tgu-116768 Taeniopygia guttata 61.50 0.00e+00 666.00
IUUC-Tru-117833 Takifugu rubripes 50.93 2.00e-139 489.00
IUUC-Tni-119907 Tetraodon nigroviridis 67.23 2.00e-82 299.00
IUUC-Xtr-132400 Xenopus tropicalis 60.45 5.00e-175 607.00
Created Date 25-Jun-2017

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