iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-070178

Ensembl Protein ID

ENSNLEP00000007631.1

UniProt Accession

G1R359; G1R359_NOMLE

Genbank Protein ID

ENSNLEP00000007631

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADFV01003922

Gene Name

SRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000006271.1	ENSNLET00000008000.1	ENSNLEP00000007631.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.00e-12	44.8	88	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvieke....eqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ +++++++      +++W+ + +  +g+ G +P+n+v+ 
   Q: 88   TFVALYDYESRTETDLSFKKGERLQIVNNTllslLREGDWWLAHSLSTGQTGYIPSNYVAP 148
           5789***********************6652222689*********************975 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGSNKSKPKD ASQRRRSLEP TENVHGAGGG AFPASQTPSK PASAEGHRGP GAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTLLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTCTCC AGCCAGGACC ATGGGCAGCA ACAAGAGCAA GCCCAAGGAC GCCAGCCAGC 60
GGCGCCGCAG TCTGGAGCCC ACCGAGAACG TGCACGGCGC TGGCGGGGGC GCTTTCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005524--F:ATP binding
GO:0020037--F:heme binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0010634--P:positive regulation of epithelial cell migration
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0046777--P:protein autophosphorylation
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0007179--P:transforming growth factor beta receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	95.76	0.00e+00	1057.00
IUUC-Aca-004237	Anolis carolinensis	89.11	0.00e+00	988.00
IUUC-Ath-007146	Arabidopsis thaliana	34.72	2.00e-22	100.00
IUUC-Ame-011887	Astyanax mexicanus	77.01	0.00e+00	853.00
IUUC-Bta-012982	Bos taurus	93.61	0.00e+00	1024.00
IUUC-Bdi-014324	Brachypodium distachyon	35.11	5.00e-23	103.00
IUUC-Bol-016049	Brassica oleracea	34.68	2.00e-17	84.70
IUUC-Bra-017486	Brassica rapa	33.68	6.00e-21	96.30
IUUC-Cja-019995	Callithrix jacchus	96.31	0.00e+00	1058.00
IUUC-Cfa-020060	Canis familiaris	95.20	0.00e+00	1049.00
IUUC-Cpo-021557	Cavia porcellus	92.62	0.00e+00	1022.00
IUUC-Csa-023711	Chlorocebus sabaeus	96.31	0.00e+00	1055.00
IUUC-Dre-028491	Danio rerio	81.03	0.00e+00	860.00
IUUC-Dno-029651	Dasypus novemcinctus	91.30	0.00e+00	1017.00
IUUC-Ete-033170	Echinops telfairi	94.10	0.00e+00	889.00
IUUC-Eca-033970	Equus caballus	89.71	0.00e+00	955.00
IUUC-Fca-036113	Felis catus	95.20	0.00e+00	1049.00
IUUC-Fal-036785	Ficedula albicollis	91.14	0.00e+00	1008.00
IUUC-Gga-040899	Gallus gallus	90.41	0.00e+00	1000.00
IUUC-Gac-042332	Gasterosteus aculeatus	79.30	0.00e+00	860.00
IUUC-Gma-043938	Glycine max	34.34	7.00e-23	102.00
IUUC-Ggo-044829	Gorilla gorilla	82.47	0.00e+00	865.00
IUUC-Hsa-046192	Homo sapiens	96.49	0.00e+00	1060.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	95.57	0.00e+00	1042.00
IUUC-Lch-049892	Latimeria chalumnae	83.21	0.00e+00	921.00
IUUC-Lpe-051166	Leersia perrieri	33.79	4.00e-23	103.00
IUUC-Loc-052812	Lepisosteus oculatus	80.33	0.00e+00	867.00
IUUC-Laf-053977	Loxodonta africana	95.57	0.00e+00	1056.00
IUUC-Mcc-055159	Macaca mulatta	94.58	0.00e+00	1048.00
IUUC-Mtr-058733	Medicago truncatula	34.09	4.00e-23	103.00
IUUC-Mga-060135	Meleagris gallopavo	91.14	0.00e+00	1010.00
IUUC-Mmr-061168	Microcebus murinus	93.13	0.00e+00	1036.00
IUUC-Mdo-063030	Monodelphis domestica	88.97	0.00e+00	998.00
IUUC-Mmu-063893	Mus musculus	95.57	0.00e+00	1050.00
IUUC-Mpu-066411	Mustela putorius furo	95.20	0.00e+00	1049.00
IUUC-Mlu-068139	Myotis lucifugus	94.48	0.00e+00	1034.00
IUUC-Ont-072130	Oreochromis niloticus	79.53	0.00e+00	883.00
IUUC-Ocu-074403	Oryctolagus cuniculus	94.30	0.00e+00	1027.00
IUUC-Ola-086527	Oryzias latipes	79.17	0.00e+00	886.00
IUUC-Oga-088493	Otolemur garnettii	95.39	0.00e+00	1051.00
IUUC-Oar-090279	Ovis aries	94.15	0.00e+00	1029.00
IUUC-Ptr-091050	Pan troglodytes	96.49	0.00e+00	1060.00
IUUC-Pan-091862	Papio anubis	96.13	0.00e+00	1050.00
IUUC-Psi-093071	Pelodiscus sinensis	90.59	0.00e+00	1001.00
IUUC-Pfo-096578	Poecilia formosa	79.89	0.00e+00	890.00
IUUC-Pab-097902	Pongo abelii	94.94	0.00e+00	1052.00
IUUC-Pop-099554	Populus trichocarpa	32.42	2.00e-23	104.00
IUUC-Ppe-102072	Prunus persica	34.89	3.00e-26	114.00
IUUC-Rno-105847	Rattus norvegicus	95.58	0.00e+00	1046.00
IUUC-Sha-107539	Sarcophilus harrisii	90.77	0.00e+00	1003.00
IUUC-Stu-112331	Solanum tuberosum	32.00	2.00e-22	101.00
IUUC-Sbi-114480	Sorghum bicolor	35.78	9.00e-24	105.00
IUUC-Ssc-115762	Sus scrofa	94.34	0.00e+00	1034.00
IUUC-Tru-117849	Takifugu rubripes	80.04	0.00e+00	852.00
IUUC-Tni-120843	Tetraodon nigroviridis	78.99	0.00e+00	877.00
IUUC-Ttr-128702	Tursiops truncatus	89.67	0.00e+00	969.00
IUUC-Vvi-131181	Vitis vinifera	33.21	4.00e-22	100.00
IUUC-Xtr-132291	Xenopus tropicalis	84.93	0.00e+00	908.00
IUUC-Xma-133134	Xiphophorus maculatus	79.53	0.00e+00	888.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence