iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012548

UUCD1 version

UUC-BoT-00036

Ensembl Protein ID

ENSBTAP00000011609.5

UniProt Accession

A4IF63; TRIM2_BOVIN

Genbank Protein ID

AAI34424.1; ENSBTAP00000011609

Protein Name

Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2

Genbank Nucleotide ID

BC134423; AAFC03054408

Gene Name

TRIM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008816.5	ENSBTAT00000011609.5	ENSBTAP00000011609.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-08	35.2	23	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle++k+ p+vlpC H+f++ Clq++       s + +CP+Cr
   Q: 23   CSICLERYKN-PKVLPCLHTFCERCLQNY---IPAHSLTLSCPVCR 64
           **********.******************...44578999*****8 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.

Protein Sequence
(Fasta)

MASEATNIPS PVVRQIDKQF LICSICLERY KNPKVLPCLH TFCERCLQNY IPAHSLTLSC 60
PVCRQTSILP EKGVAALQNN FFITNLMDVL QRSPGSSAEE SSILETVTAV AAGKPLSCPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGATGCAC CGGAGAGGCG GATATGGAAT ACCGGTAAGG GCGCTTCTAA GGGCGCGGGG 60
ATGCCTTTTC TGGGCTCACA GGTGGCTCCT GGGCACTGTT TTGGAGAAAC GAGTCGTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043523--P:regulation of neuron apoptotic process

KEGG

bta:538617

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002127	Ailuropoda melanoleuca	98.92	0.00e+00	1530.00
IUUC-Apl-003865	Anas platyrhynchos	96.51	0.00e+00	1499.00
IUUC-Aca-004825	Anolis carolinensis	94.98	0.00e+00	1307.00
IUUC-Ame-011612	Astyanax mexicanus	80.72	0.00e+00	1276.00
IUUC-Cja-019580	Callithrix jacchus	98.52	0.00e+00	1528.00
IUUC-Cpo-022342	Cavia porcellus	95.43	0.00e+00	1472.00
IUUC-Csa-023735	Chlorocebus sabaeus	98.39	0.00e+00	1524.00
IUUC-Cho-025025	Choloepus hoffmanni	87.42	0.00e+00	808.00
IUUC-Csv-026112	Ciona savignyi	28.12	1.00e-83	304.00
IUUC-Dre-028599	Danio rerio	79.73	0.00e+00	1210.00
IUUC-Dno-029768	Dasypus novemcinctus	98.66	0.00e+00	1529.00
IUUC-Dor-030841	Dipodomys ordii	90.19	0.00e+00	1372.00
IUUC-Eca-033960	Equus caballus	99.06	0.00e+00	1533.00
IUUC-Eeu-035207	Erinaceus europaeus	89.03	0.00e+00	1166.00
IUUC-Fca-035695	Felis catus	98.92	0.00e+00	1531.00
IUUC-Fal-037000	Ficedula albicollis	96.51	0.00e+00	1504.00
IUUC-Gmo-038767	Gadus morhua	78.23	0.00e+00	1204.00
IUUC-Gga-041007	Gallus gallus	96.37	0.00e+00	1502.00
IUUC-Gac-042586	Gasterosteus aculeatus	84.01	0.00e+00	1328.00
IUUC-Ggo-045221	Gorilla gorilla	98.92	0.00e+00	1532.00
IUUC-Hsa-046365	Homo sapiens	98.92	0.00e+00	1531.00
IUUC-Lch-050198	Latimeria chalumnae	84.33	0.00e+00	1317.00
IUUC-Loc-052583	Lepisosteus oculatus	89.52	0.00e+00	1367.00
IUUC-Laf-054233	Loxodonta africana	98.52	0.00e+00	1526.00
IUUC-Mcc-055569	Macaca mulatta	98.56	0.00e+00	1429.00
IUUC-Mga-059355	Meleagris gallopavo	95.58	0.00e+00	1489.00
IUUC-Mmr-061171	Microcebus murinus	98.66	0.00e+00	1527.00
IUUC-Mdo-062885	Monodelphis domestica	97.45	0.00e+00	1512.00
IUUC-Mmu-063562	Mus musculus	98.12	0.00e+00	1521.00
IUUC-Mpu-066097	Mustela putorius furo	98.92	0.00e+00	1531.00
IUUC-Mlu-068044	Myotis lucifugus	99.06	0.00e+00	1531.00
IUUC-Nle-069532	Nomascus leucogenys	98.66	0.00e+00	1528.00
IUUC-Opr-070346	Ochotona princeps	97.58	0.00e+00	1508.00
IUUC-Ont-071572	Oreochromis niloticus	84.27	0.00e+00	1334.00
IUUC-Oan-072836	Ornithorhynchus anatinus	97.26	0.00e+00	1414.00
IUUC-Ocu-074750	Oryctolagus cuniculus	98.25	0.00e+00	1522.00
IUUC-Ola-087547	Oryzias latipes	82.39	0.00e+00	1312.00
IUUC-Oga-088484	Otolemur garnettii	98.66	0.00e+00	1527.00
IUUC-Oar-089231	Ovis aries	98.79	0.00e+00	1519.00
IUUC-Ptr-091007	Pan troglodytes	97.18	0.00e+00	1496.00
IUUC-Pan-092589	Papio anubis	98.66	0.00e+00	1528.00
IUUC-Psi-093880	Pelodiscus sinensis	96.77	0.00e+00	1504.00
IUUC-Pma-094132	Petromyzon marinus	86.94	5.00e-133	466.00
IUUC-Pfo-096688	Poecilia formosa	80.55	0.00e+00	1163.00
IUUC-Pab-098260	Pongo abelii	98.79	0.00e+00	1531.00
IUUC-Pca-100644	Procavia capensis	98.11	0.00e+00	967.00
IUUC-Pva-102141	Pteropus vampyrus	99.06	0.00e+00	1533.00
IUUC-Rno-105358	Rattus norvegicus	95.03	0.00e+00	1459.00
IUUC-Sha-106703	Sarcophilus harrisii	97.45	0.00e+00	1506.00
IUUC-Sar-113100	Sorex araneus	98.53	0.00e+00	971.00
IUUC-Ssc-116118	Sus scrofa	98.92	0.00e+00	1529.00
IUUC-Tgu-117257	Taeniopygia guttata	96.37	0.00e+00	1500.00
IUUC-Tru-118683	Takifugu rubripes	82.22	0.00e+00	1299.00
IUUC-Tni-120534	Tetraodon nigroviridis	82.12	0.00e+00	1285.00
IUUC-Tbe-127438	Tupaia belangeri	89.43	0.00e+00	924.00
IUUC-Ttr-128897	Tursiops truncatus	98.12	0.00e+00	1515.00
IUUC-Vpa-130582	Vicugna pacos	99.25	1.00e-159	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence