iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091543

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Thyroid hormone receptor interactor 12

Genbank Nucleotide ID

AACZ03020209

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013005.5	ENSPTRT00000024112.5	ENSPTRP00000022237.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-96	324.1	1613	1992

Active Site

Position(s)	Description	Evidence
1959	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1613 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1695
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1696 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1782
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1783 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1857
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1858 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1944
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1945 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 1992
           988888***************************************985 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSCSSSSA VIVPQPEDPD RANTSERQKT 60
GQVPKKDNSR GVKRSASPDY NRTNSPSSAK KPKALQHTES PSETNKPHSK SKKRHLDQEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACTTGCCGC GTCCACCATG TCCGGACCGG AGACTTTGGG CCTAACTTAG ATAATTGGGG 60
CGCAGCTCCT GGGCGGCGGG GGCAAGCCTT GGGGGAGGGG GCCAGCTGAG AGGTTGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0675--Receptor
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.69	2.00e-126	447.00
IUUC-Aml-001502	Ailuropoda melanoleuca	95.83	0.00e+00	3626.00
IUUC-Atr-002821	Amborella trichopoda	37.45	6.00e-117	416.00
IUUC-Apl-003531	Anas platyrhynchos	91.04	0.00e+00	3360.00
IUUC-Aly-005962	Arabidopsis lyrata	38.94	7.00e-115	409.00
IUUC-Ath-006636	Arabidopsis thaliana	38.66	6.00e-114	406.00
IUUC-Ago-007875	Ashbya gossypii	36.20	8.00e-82	299.00
IUUC-Acl-008242	Aspergillus clavatus	35.70	1.00e-113	405.00
IUUC-Afl-008736	Aspergillus flavus	38.83	1.00e-110	395.00
IUUC-Afu-008812	Aspergillus fumigatus	35.10	4.00e-114	407.00
IUUC-Ani-009407	Aspergillus nidulans	36.82	2.00e-110	394.00
IUUC-Ang-009763	Aspergillus niger	40.00	4.00e-106	380.00
IUUC-Aor-009941	Aspergillus oryzae	30.77	1.00e-112	401.00
IUUC-Ate-010459	Aspergillus terreus	36.42	8.00e-86	312.00
IUUC-Ame-011761	Astyanax mexicanus	85.48	0.00e+00	2919.00
IUUC-Bgr-012265	Blumeria graminis	34.86	3.00e-104	374.00
IUUC-Bta-013070	Bos taurus	98.39	0.00e+00	3645.00
IUUC-Bci-013890	Botrytis cinerea	39.72	1.00e-102	368.00
IUUC-Bdi-014046	Brachypodium distachyon	38.47	5.00e-122	432.00
IUUC-Bol-015942	Brassica oleracea	44.23	1.00e-114	408.00
IUUC-Bra-016849	Brassica rapa	44.23	3.00e-114	407.00
IUUC-Cja-019046	Callithrix jacchus	96.43	0.00e+00	3600.00
IUUC-Cfa-020521	Canis familiaris	94.95	0.00e+00	3484.00
IUUC-Cpo-021639	Cavia porcellus	91.68	0.00e+00	3501.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	1.00e-89	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	95.36	0.00e+00	3597.00
IUUC-Cho-024380	Choloepus hoffmanni	88.77	0.00e+00	3264.00
IUUC-Cin-025482	Ciona intestinalis	51.21	8.00e-160	556.00
IUUC-Csv-026121	Ciona savignyi	49.47	0.00e+00	1562.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.98	1.00e-110	395.00
IUUC-Cne-026857	Cryptococcus neoformans	39.89	1.00e-94	342.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	3.00e-74	274.00
IUUC-Dre-028174	Danio rerio	85.33	0.00e+00	2966.00
IUUC-Dor-030939	Dipodomys ordii	88.27	0.00e+00	2787.00
IUUC-Dse-031444	Dothistroma septosporum	39.31	2.00e-105	378.00
IUUC-Dme-032162	Drosophila melanogaster	63.41	4.00e-158	553.00
IUUC-Ete-032345	Echinops telfairi	92.38	0.00e+00	2308.00
IUUC-Eca-033229	Equus caballus	95.25	0.00e+00	3534.00
IUUC-Eeu-035205	Erinaceus europaeus	88.81	0.00e+00	3152.00
IUUC-Fca-036444	Felis catus	95.05	0.00e+00	3569.00
IUUC-Fal-037131	Ficedula albicollis	90.28	0.00e+00	3401.00
IUUC-Fox-038035	Fusarium oxysporum	38.54	4.00e-110	392.00
IUUC-Fso-038320	Fusarium solani	36.91	4.00e-110	393.00
IUUC-Gmo-039497	Gadus morhua	82.80	0.00e+00	3109.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.90	2.00e-108	387.00
IUUC-Gga-041021	Gallus gallus	90.28	0.00e+00	3405.00
IUUC-Gac-042474	Gasterosteus aculeatus	84.23	0.00e+00	3089.00
IUUC-Gma-043060	Glycine max	38.92	4.00e-122	433.00
IUUC-Ggo-044855	Gorilla gorilla	96.67	0.00e+00	3609.00
IUUC-Hsa-046147	Homo sapiens	99.90	0.00e+00	3637.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	6.00e-125	442.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	96.45	0.00e+00	3497.00
IUUC-Kpa-049098	Komagataella pastoris	38.10	3.00e-86	313.00
IUUC-Lch-049818	Latimeria chalumnae	84.39	0.00e+00	3070.00
IUUC-Lpe-051017	Leersia perrieri	38.44	1.00e-118	421.00
IUUC-Loc-051777	Lepisosteus oculatus	84.63	0.00e+00	3278.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	4.00e-112	400.00
IUUC-Laf-053727	Loxodonta africana	95.44	0.00e+00	3578.00
IUUC-Mcc-055799	Macaca mulatta	93.90	0.00e+00	3505.00
IUUC-Meu-056065	Macropus eugenii	94.05	0.00e+00	2103.00
IUUC-Mor-057054	Magnaporthe oryzae	38.86	2.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.55	1.00e-109	392.00
IUUC-Mtr-057849	Medicago truncatula	37.36	1.00e-113	405.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	6.00e-107	382.00
IUUC-Mga-059580	Meleagris gallopavo	90.92	0.00e+00	2956.00
IUUC-Mvi-060507	Microbotryum violaceum	40.19	7.00e-113	402.00
IUUC-Mmr-060816	Microcebus murinus	94.63	0.00e+00	3565.00
IUUC-Mdo-062866	Monodelphis domestica	90.72	0.00e+00	3272.00
IUUC-Mmu-063906	Mus musculus	95.80	0.00e+00	3563.00
IUUC-Mac-064675	Musa acuminata	38.92	2.00e-111	396.00
IUUC-Mpu-066199	Mustela putorius furo	92.89	0.00e+00	3461.00
IUUC-Mlu-067110	Myotis lucifugus	95.90	0.00e+00	3558.00
IUUC-Nfi-068482	Neosartorya fischeri	35.25	5.00e-114	406.00
IUUC-Ncr-068906	Neurospora crassa	39.13	2.00e-109	391.00
IUUC-Nle-069410	Nomascus leucogenys	96.32	0.00e+00	3593.00
IUUC-Opr-070401	Ochotona princeps	86.34	0.00e+00	3018.00
IUUC-Ont-072100	Oreochromis niloticus	80.02	0.00e+00	3046.00
IUUC-Oan-073121	Ornithorhynchus anatinus	90.76	0.00e+00	3531.00
IUUC-Ocu-074623	Oryctolagus cuniculus	92.89	0.00e+00	3494.00
IUUC-Oba-075380	Oryza barthii	36.51	2.00e-113	404.00
IUUC-Obr-076915	Oryza brachyantha	37.77	6.00e-119	422.00
IUUC-Ogl-077055	Oryza glaberrima	38.70	2.00e-118	421.00
IUUC-Ogu-078892	Oryza glumaepatula	40.95	1.00e-112	401.00
IUUC-Oin-079256	Oryza indica	38.52	4.00e-117	416.00
IUUC-Olo-080343	Oryza longistaminata	38.52	2.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	38.24	8.00e-117	416.00
IUUC-Oni-083047	Oryza nivara	41.13	1.00e-114	408.00
IUUC-Opu-083641	Oryza punctata	36.44	3.00e-111	396.00
IUUC-Oru-084439	Oryza rufipogon	40.95	2.00e-113	403.00
IUUC-Osa-085972	Oryza sativa	38.44	1.00e-116	413.00
IUUC-Ola-087173	Oryzias latipes	80.53	0.00e+00	3029.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.89	7.00e-89	321.00
IUUC-Oga-087908	Otolemur garnettii	95.59	0.00e+00	3579.00
IUUC-Oar-090277	Ovis aries	95.11	0.00e+00	3605.00
IUUC-Pan-092243	Papio anubis	93.86	0.00e+00	3502.00
IUUC-Psi-093150	Pelodiscus sinensis	92.36	0.00e+00	3526.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.94	3.00e-113	404.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	2.00e-107	383.00
IUUC-Pfo-096267	Poecilia formosa	79.45	0.00e+00	3020.00
IUUC-Pab-098072	Pongo abelii	96.62	0.00e+00	3606.00
IUUC-Pop-099190	Populus trichocarpa	41.34	3.00e-116	414.00
IUUC-Pca-100311	Procavia capensis	90.83	0.00e+00	3294.00
IUUC-Ppe-101284	Prunus persica	37.52	2.00e-116	414.00
IUUC-Pva-102215	Pteropus vampyrus	90.29	0.00e+00	1298.00
IUUC-Pgr-103694	Puccinia graminis	40.68	3.00e-104	374.00
IUUC-Ptt-103916	Puccinia triticina	39.00	2.00e-98	355.00
IUUC-Pte-104346	Pyrenophora teres	39.59	2.00e-110	394.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.66	2.00e-110	394.00
IUUC-Rno-105315	Rattus norvegicus	92.60	0.00e+00	3422.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	5.00e-71	263.00
IUUC-Sha-106835	Sarcophilus harrisii	92.36	0.00e+00	3557.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.58	1.00e-94	341.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.54	1.00e-94	342.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.92	3.00e-106	380.00
IUUC-Smo-109590	Selaginella moellendorffii	43.28	3.00e-112	400.00
IUUC-Sit-110717	Setaria italica	37.94	4.00e-120	426.00
IUUC-Sly-111469	Solanum lycopersicum	39.08	9.00e-122	432.00
IUUC-Stu-112896	Solanum tuberosum	38.22	9.00e-106	377.00
IUUC-Sar-113224	Sorex araneus	92.70	0.00e+00	1952.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	9.00e-124	438.00
IUUC-Sre-114993	Sporisorium reilianum	34.09	2.00e-100	362.00
IUUC-Ssc-115535	Sus scrofa	93.26	0.00e+00	3454.00
IUUC-Tgu-117493	Taeniopygia guttata	90.62	0.00e+00	2687.00
IUUC-Tru-118669	Takifugu rubripes	80.28	0.00e+00	3007.00
IUUC-Tsy-119373	Tarsius syrichta	94.94	0.00e+00	1869.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.98	0.00e+00	867.00
IUUC-Tca-121779	Theobroma cacao	38.76	1.00e-115	412.00
IUUC-Tre-122195	Trichoderma reesei	35.80	1.00e-105	378.00
IUUC-Tvi-122650	Trichoderma virens	35.93	4.00e-109	390.00
IUUC-Tae-123580	Triticum aestivum	38.58	1.00e-124	440.00
IUUC-Tur-126295	Triticum urartu	38.54	2.00e-125	444.00
IUUC-Tme-126964	Tuber melanosporum	40.48	1.00e-105	378.00
IUUC-Tbe-128149	Tupaia belangeri	81.95	0.00e+00	1467.00
IUUC-Ttr-128165	Tursiops truncatus	94.87	0.00e+00	3061.00
IUUC-Uma-129365	Ustilago maydis	36.07	5.00e-89	323.00
IUUC-Vda-129725	Verticillium dahliae	41.08	5.00e-109	389.00
IUUC-Vpa-130678	Vicugna pacos	98.91	0.00e+00	2691.00
IUUC-Vvi-131147	Vitis vinifera	39.23	2.00e-122	434.00
IUUC-Xtr-132636	Xenopus tropicalis	87.43	0.00e+00	3264.00
IUUC-Xma-133458	Xiphophorus maculatus	79.97	0.00e+00	3063.00
IUUC-Yli-134481	Yarrowia lipolytica	39.56	6.00e-98	352.00
IUUC-Zma-135782	Zea mays	37.87	5.00e-118	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence