iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	50.32	6.00e-128	456.00	IUUC-Hsa-046081
UBD/Alpha-Helix/UBA	50.11	4.00e-128	456.00	IUUC-Mmu-063504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization (PubMed:23396260). Plays an essential role in larval development (PubMed:19737560, PubMed:19605499). Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway (PubMed:19737560). Does not appear to regulate apoptosis and proliferation (PubMed:19605499). In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage (PubMed:19737560). Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins (PubMed:19605499).

Protein Sequence
(Fasta)

MRPAAPGTTP NGASSDIRHQ RGVAPIPFGS TNSAIDAHHN SEIRVGRHRA KLDEIRESLK 60
AYEHEAGLLS SHVALGSLAT PSSSSVSHSD ITNDNAEVMN FSSSSSNAAA TTTTVSSAAV 120

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Nucleotide Sequence
(Fasta)

ATTCCCATCG CCTTCTCCGT GTGTGTGTTT GTCAGTGTTC GGCAGGAGGC CCTCCTTTGC 60
ATTGTATTCC CCTGGAATGC GACCTGCTGC CCCTGGTACT ACTCCAAATG GTGCATCTTC 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0418--Kinase
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0001225--F:RNA polymerase II transcription coactivator binding
GO:0045176--P:apical protein localization
GO:0030421--P:defecation
GO:0008340--P:determination of adult lifespan
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0061067--P:negative regulation of dauer larval development
GO:0042308--P:negative regulation of protein import into nucleus
GO:0002119--P:nematode larval development
GO:0018105--P:peptidyl-serine phosphorylation
GO:0060465--P:pharynx development
GO:0043065--P:positive regulation of apoptotic process
GO:0045793--P:positive regulation of cell size
GO:0048621--P:post-embryonic digestive tract morphogenesis
GO:0006468--P:protein phosphorylation
GO:0046620--P:regulation of organ growth

KEGG

cel:CELE_T20F10.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001895	Ailuropoda melanoleuca	50.32	1.00e-128	452.00
IUUC-Apl-003278	Anas platyrhynchos	49.89	3.00e-128	451.00
IUUC-Aca-005319	Anolis carolinensis	49.68	1.00e-127	449.00
IUUC-Ame-011324	Astyanax mexicanus	49.37	2.00e-129	455.00
IUUC-Bta-013438	Bos taurus	50.75	4.00e-128	451.00
IUUC-Cja-019072	Callithrix jacchus	50.54	2.00e-129	455.00
IUUC-Cfa-021267	Canis familiaris	50.32	1.00e-128	453.00
IUUC-Cpo-021985	Cavia porcellus	48.59	7.00e-120	423.00
IUUC-Csa-023255	Chlorocebus sabaeus	50.32	7.00e-129	454.00
IUUC-Cho-024461	Choloepus hoffmanni	56.46	5.00e-110	391.00
IUUC-Cin-025264	Ciona intestinalis	50.13	2.00e-104	370.00
IUUC-Dre-028034	Danio rerio	49.69	6.00e-129	454.00
IUUC-Dno-029888	Dasypus novemcinctus	50.11	4.00e-128	451.00
IUUC-Dor-030172	Dipodomys ordii	48.61	2.00e-121	428.00
IUUC-Dme-031656	Drosophila melanogaster	52.81	2.00e-125	442.00
IUUC-Ete-032813	Echinops telfairi	50.11	1.00e-126	446.00
IUUC-Eca-033781	Equus caballus	50.32	2.00e-128	452.00
IUUC-Eeu-035007	Erinaceus europaeus	50.75	2.00e-128	452.00
IUUC-Fca-036142	Felis catus	50.32	2.00e-128	452.00
IUUC-Fal-036626	Ficedula albicollis	50.11	4.00e-128	451.00
IUUC-Gmo-039195	Gadus morhua	48.96	6.00e-112	397.00
IUUC-Gga-040553	Gallus gallus	49.89	3.00e-128	451.00
IUUC-Gac-042031	Gasterosteus aculeatus	50.97	1.00e-126	446.00
IUUC-Ggo-045242	Gorilla gorilla	50.32	6.00e-129	454.00
IUUC-Hsa-046081	Homo sapiens	50.32	9.00e-129	453.00
IUUC-Itr-048668	Ictidomys tridecemlineatus	50.32	6.00e-128	450.00
IUUC-Lch-049425	Latimeria chalumnae	50.75	2.00e-128	452.00
IUUC-Loc-052418	Lepisosteus oculatus	48.12	2.00e-124	439.00
IUUC-Laf-053710	Loxodonta africana	49.89	4.00e-127	448.00
IUUC-Mcc-055079	Macaca mulatta	50.32	7.00e-129	453.00
IUUC-Meu-056509	Macropus eugenii	44.13	1.00e-90	326.00
IUUC-Mga-059713	Meleagris gallopavo	50.11	3.00e-128	452.00
IUUC-Mmr-061728	Microcebus murinus	50.32	2.00e-128	452.00
IUUC-Mdo-061942	Monodelphis domestica	50.11	2.00e-128	452.00
IUUC-Mmu-063504	Mus musculus	50.11	1.00e-128	452.00
IUUC-Mpu-066034	Mustela putorius furo	50.32	8.00e-129	453.00
IUUC-Mlu-067986	Myotis lucifugus	50.32	1.00e-128	452.00
IUUC-Nle-069202	Nomascus leucogenys	50.32	7.00e-129	454.00
IUUC-Opr-070801	Ochotona princeps	50.32	2.00e-126	445.00
IUUC-Ont-072487	Oreochromis niloticus	50.75	4.00e-127	447.00
IUUC-Oan-073128	Ornithorhynchus anatinus	49.68	6.00e-126	444.00
IUUC-Ocu-073998	Oryctolagus cuniculus	50.32	2.00e-128	452.00
IUUC-Ola-086858	Oryzias latipes	51.40	1.00e-128	453.00
IUUC-Oga-088874	Otolemur garnettii	49.57	1.00e-126	446.00
IUUC-Oar-089236	Ovis aries	50.64	5.00e-127	447.00
IUUC-Ptr-091425	Pan troglodytes	50.32	6.00e-129	454.00
IUUC-Pan-091851	Papio anubis	50.32	6.00e-129	454.00
IUUC-Psi-093920	Pelodiscus sinensis	48.83	2.00e-122	432.00
IUUC-Pfo-096326	Poecilia formosa	48.96	3.00e-126	445.00
IUUC-Pab-097815	Pongo abelii	50.32	7.00e-129	453.00
IUUC-Pca-101081	Procavia capensis	48.83	8.00e-122	430.00
IUUC-Pva-102836	Pteropus vampyrus	50.22	2.00e-127	448.00
IUUC-Ptt-103762	Puccinia triticina	37.44	4.00e-87	314.00
IUUC-Rno-106053	Rattus norvegicus	50.11	2.00e-128	452.00
IUUC-Sha-106843	Sarcophilus harrisii	50.54	1.00e-128	452.00
IUUC-Sar-113649	Sorex araneus	49.89	2.00e-124	439.00
IUUC-Ssc-115486	Sus scrofa	56.12	3.00e-110	390.00
IUUC-Tgu-116903	Taeniopygia guttata	49.89	4.00e-126	444.00
IUUC-Tru-118760	Takifugu rubripes	50.22	2.00e-127	449.00
IUUC-Tsy-119361	Tarsius syrichta	50.32	4.00e-128	451.00
IUUC-Tni-120058	Tetraodon nigroviridis	51.64	2.00e-127	449.00
IUUC-Tbe-127681	Tupaia belangeri	50.75	3.00e-129	455.00
IUUC-Ttr-129256	Tursiops truncatus	47.88	6.00e-121	427.00
IUUC-Vpa-130538	Vicugna pacos	50.43	2.00e-128	452.00
IUUC-Xtr-132593	Xenopus tropicalis	48.72	6.00e-123	434.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence