iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055890

UUCD1 version

UUC-MaM-00570

Ensembl Protein ID

ENSMMUP00000045539.1

UniProt Accession

F7E320; F7E320_MACMU

Genbank Protein ID

AFH29071.1; AFI35846.1; EHH21074.1

Protein Name

Suppressor of cytokine signaling 2

Genbank Nucleotide ID

JSUE03007476; JV045775; CM001263

Gene Name

SOCS2; EGK_04058

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000047406.1	ENSMMUT00000056692.1	ENSMMUP00000045539.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.80e-15	55.6	158	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 9    seprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + +SLqhLCRl+I++c+g      i++LPLP +LkdYL+++++q
   Q: 158  ISAPSLQHLCRLTINKCTGA-----IWGLPLPTRLKDYLEEYKFQ 197
           5689****************.....8***************9886 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PEAARLAKAL RELGQTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACCGGGAA GCGGGGGGAG GGGAGCGAGG AACCTCCCGG GTGGGGATGC GGCAGCTCCC 60
GCACCTCCGC ACCCGGGTTT GGTGCCTCAG GGCCCCGCAG CGCTTTAGGG TGGAGAACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0032355--P:response to estradiol

KEGG

mcc:715772

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	95.45	4.00e-104	370.00
IUUC-Apl-003484	Anas platyrhynchos	79.08	1.00e-71	261.00
IUUC-Aca-004253	Anolis carolinensis	71.34	3.00e-71	260.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	3.10e-02	32.70
IUUC-Ame-011267	Astyanax mexicanus	62.28	6.00e-59	219.00
IUUC-Bta-013183	Bos taurus	93.94	1.00e-97	348.00
IUUC-Bra-017915	Brassica rapa	33.90	5.80e-02	32.00
IUUC-Cja-018862	Callithrix jacchus	98.48	6.00e-103	365.00
IUUC-Cfa-020226	Canis familiaris	93.91	3.00e-95	340.00
IUUC-Cpo-022414	Cavia porcellus	95.45	4.00e-104	370.00
IUUC-Csa-023758	Chlorocebus sabaeus	98.99	2.00e-108	384.00
IUUC-Cho-024471	Choloepus hoffmanni	85.53	6.00e-71	259.00
IUUC-Dre-028288	Danio rerio	56.48	5.00e-63	233.00
IUUC-Dno-029036	Dasypus novemcinctus	95.96	1.00e-105	375.00
IUUC-Dor-030447	Dipodomys ordii	97.35	2.00e-86	310.00
IUUC-Ete-033023	Echinops telfairi	93.43	1.00e-109	388.00
IUUC-Fca-036469	Felis catus	96.46	4.00e-100	356.00
IUUC-Fal-036642	Ficedula albicollis	73.29	1.00e-69	255.00
IUUC-Gmo-039331	Gadus morhua	61.54	4.00e-35	139.00
IUUC-Gga-040809	Gallus gallus	76.10	6.00e-72	262.00
IUUC-Gac-041398	Gasterosteus aculeatus	55.08	2.00e-57	214.00
IUUC-Ggo-045341	Gorilla gorilla	98.99	4.00e-103	366.00
IUUC-Hsa-046557	Homo sapiens	98.48	2.00e-115	407.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	81.73	2.00e-92	331.00
IUUC-Lch-050160	Latimeria chalumnae	60.40	2.00e-48	184.00
IUUC-Loc-051825	Lepisosteus oculatus	55.73	3.00e-60	224.00
IUUC-Laf-053560	Loxodonta africana	94.44	2.00e-97	347.00
IUUC-Meu-056218	Macropus eugenii	79.80	2.00e-95	341.00
IUUC-Mga-059755	Meleagris gallopavo	78.29	3.00e-70	257.00
IUUC-Mmr-061387	Microcebus murinus	96.46	2.00e-104	371.00
IUUC-Mdo-062383	Monodelphis domestica	80.81	2.00e-95	341.00
IUUC-Mmu-063443	Mus musculus	92.93	9.00e-101	358.00
IUUC-Mpu-066459	Mustela putorius furo	94.95	2.00e-98	350.00
IUUC-Mlu-068040	Myotis lucifugus	96.46	4.00e-106	376.00
IUUC-Nle-069016	Nomascus leucogenys	92.93	5.00e-99	353.00
IUUC-Opr-071087	Ochotona princeps	88.38	3.00e-102	363.00
IUUC-Ont-072340	Oreochromis niloticus	56.25	5.00e-59	220.00
IUUC-Oan-073443	Ornithorhynchus anatinus	77.78	2.00e-89	321.00
IUUC-Ocu-074539	Oryctolagus cuniculus	94.42	2.00e-98	351.00
IUUC-Ogu-078951	Oryza glumaepatula	23.36	4.40e-02	32.70
IUUC-Oin-079476	Oryza indica	23.36	3.60e-02	33.10
IUUC-Oni-082613	Oryza nivara	23.36	3.60e-02	33.10
IUUC-Oru-085265	Oryza rufipogon	23.36	3.80e-02	32.70
IUUC-Ola-087004	Oryzias latipes	58.86	5.00e-54	202.00
IUUC-Oga-088438	Otolemur garnettii	96.46	2.00e-105	374.00
IUUC-Oar-089932	Ovis aries	93.94	2.00e-97	347.00
IUUC-Ptr-091037	Pan troglodytes	98.99	4.00e-103	366.00
IUUC-Pan-092767	Papio anubis	98.99	2.00e-103	367.00
IUUC-Psi-093099	Pelodiscus sinensis	76.10	5.00e-73	266.00
IUUC-Pma-094671	Petromyzon marinus	47.71	6.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	50.52	7.00e-55	206.00
IUUC-Pab-098319	Pongo abelii	98.48	3.00e-108	384.00
IUUC-Pca-101117	Procavia capensis	92.93	1.00e-98	352.00
IUUC-Pva-102117	Pteropus vampyrus	94.44	2.00e-96	344.00
IUUC-Rno-105913	Rattus norvegicus	92.42	3.00e-100	357.00
IUUC-Sha-106500	Sarcophilus harrisii	80.71	7.00e-94	335.00
IUUC-Ssc-115252	Sus scrofa	95.45	3.00e-104	370.00
IUUC-Tgu-117524	Taeniopygia guttata	74.84	4.00e-69	253.00
IUUC-Tsy-119335	Tarsius syrichta	94.70	8.00e-85	305.00
IUUC-Tni-120263	Tetraodon nigroviridis	53.72	4.00e-56	210.00
IUUC-Tbe-127915	Tupaia belangeri	93.94	6.00e-95	339.00
IUUC-Ttr-128372	Tursiops truncatus	94.95	1.00e-103	368.00
IUUC-Vpa-130422	Vicugna pacos	97.35	4.00e-86	309.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence