iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132862

Ensembl Protein ID

ENSXETP00000042118.3

UniProt Accession

F6Z8A1; F6Z8A1_XENTR

Genbank Protein ID

ENSXETP00000042118

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AAMC01016789

Gene Name

plcg1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000019423.3	ENSXETT00000042118.3	ENSXETP00000042118.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.80e-12	45.6	784	841

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           +k  v++l+dy+aq +deLt++k  +++ +  e+q++gW++g  +  gk+ + fP+n+ve++
   Q: 784  FKCSVRALFDYKAQREDELTFTKNTIIQNV--EKQEGGWWRG--DCGGKKQMwFPANYVEEI 841
           56689************************9..9*********..666655544******997 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MESLPLLNGF APCGQSEAEL THLCRSLEVG TVMTLFYSKK SQKPERRTFQ VKLETRQVTW 60
SRVADKVEGA VDIREIKEIR PSKNSRDFDR YQEDPTVRLE QAHCFVILYG TEFRLKTLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAATCCC TGCCGCTTCT CAATGGGTTC GCTCCATGTG GGCAAAGTGA AGCCGAGCTC 60
ACCCATCTGT GCCGGAGTTT GGAGGTGGGC ACCGTCATGA CCCTCTTCTA CTCCAAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0001525--P:angiogenesis
GO:0048844--P:artery morphogenesis
GO:0031101--P:fin regeneration
GO:0030851--P:granulocyte differentiation
GO:0060218--P:hematopoietic stem cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0009395--P:phospholipid catabolic process
GO:0035477--P:regulation of angioblast cell migration involved in selective angioblast sprouting
GO:0008016--P:regulation of heart contraction
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	77.85	0.00e+00	2041.00
IUUC-Aca-005291	Anolis carolinensis	78.17	0.00e+00	2006.00
IUUC-Ame-011004	Astyanax mexicanus	63.99	0.00e+00	1633.00
IUUC-Bta-012660	Bos taurus	77.72	0.00e+00	1916.00
IUUC-Cja-019206	Callithrix jacchus	77.33	0.00e+00	2019.00
IUUC-Cfa-020257	Canis familiaris	78.05	0.00e+00	1935.00
IUUC-Cpo-022391	Cavia porcellus	72.87	0.00e+00	1867.00
IUUC-Csa-024170	Chlorocebus sabaeus	78.43	0.00e+00	1504.00
IUUC-Dre-027944	Danio rerio	66.54	0.00e+00	1709.00
IUUC-Dno-029440	Dasypus novemcinctus	77.73	0.00e+00	1848.00
IUUC-Dor-031001	Dipodomys ordii	77.25	0.00e+00	2026.00
IUUC-Eca-033809	Equus caballus	78.05	0.00e+00	1938.00
IUUC-Fca-036510	Felis catus	77.97	0.00e+00	1935.00
IUUC-Fal-037541	Ficedula albicollis	78.13	0.00e+00	1826.00
IUUC-Gmo-038630	Gadus morhua	61.50	0.00e+00	1322.00
IUUC-Gga-040142	Gallus gallus	79.21	0.00e+00	2005.00
IUUC-Ggo-045063	Gorilla gorilla	78.01	0.00e+00	2044.00
IUUC-Hsa-046428	Homo sapiens	77.93	0.00e+00	2042.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	78.06	0.00e+00	1999.00
IUUC-Lch-049766	Latimeria chalumnae	73.77	0.00e+00	1773.00
IUUC-Loc-052285	Lepisosteus oculatus	71.97	0.00e+00	1855.00
IUUC-Laf-053365	Loxodonta africana	77.76	0.00e+00	1929.00
IUUC-Mcc-054871	Macaca mulatta	78.02	0.00e+00	2038.00
IUUC-Meu-056724	Macropus eugenii	73.08	0.00e+00	1768.00
IUUC-Mga-059329	Meleagris gallopavo	77.24	0.00e+00	1871.00
IUUC-Mmr-061110	Microcebus murinus	77.79	0.00e+00	2032.00
IUUC-Mdo-062448	Monodelphis domestica	78.15	0.00e+00	2042.00
IUUC-Mmu-063565	Mus musculus	77.79	0.00e+00	2025.00
IUUC-Mpu-066683	Mustela putorius furo	77.93	0.00e+00	2044.00
IUUC-Mlu-067779	Myotis lucifugus	77.62	0.00e+00	1931.00
IUUC-Nle-069219	Nomascus leucogenys	79.66	0.00e+00	1726.00
IUUC-Opr-070766	Ochotona princeps	77.19	0.00e+00	1196.00
IUUC-Ont-072524	Oreochromis niloticus	69.64	0.00e+00	1800.00
IUUC-Oan-073214	Ornithorhynchus anatinus	82.42	7.00e-41	159.00
IUUC-Ocu-074361	Oryctolagus cuniculus	76.83	0.00e+00	2002.00
IUUC-Ola-086820	Oryzias latipes	68.06	0.00e+00	1810.00
IUUC-Oga-088172	Otolemur garnettii	78.30	0.00e+00	2048.00
IUUC-Oar-090306	Ovis aries	75.33	0.00e+00	1852.00
IUUC-Ptr-090682	Pan troglodytes	78.01	0.00e+00	2044.00
IUUC-Pan-092835	Papio anubis	78.58	0.00e+00	1465.00
IUUC-Psi-093344	Pelodiscus sinensis	77.42	0.00e+00	1996.00
IUUC-Pfo-096984	Poecilia formosa	68.59	0.00e+00	1771.00
IUUC-Pab-097871	Pongo abelii	78.16	0.00e+00	2006.00
IUUC-Pca-100772	Procavia capensis	72.65	0.00e+00	1868.00
IUUC-Pva-102790	Pteropus vampyrus	78.62	0.00e+00	2005.00
IUUC-Rno-105974	Rattus norvegicus	77.92	0.00e+00	2045.00
IUUC-Sar-112995	Sorex araneus	76.38	0.00e+00	1965.00
IUUC-Ssc-115360	Sus scrofa	77.76	0.00e+00	2036.00
IUUC-Tgu-116585	Taeniopygia guttata	76.27	0.00e+00	1892.00
IUUC-Tru-117742	Takifugu rubripes	69.71	0.00e+00	1838.00
IUUC-Tsy-119259	Tarsius syrichta	83.33	0.00e+00	735.00
IUUC-Tbe-127504	Tupaia belangeri	73.18	0.00e+00	1015.00
IUUC-Ttr-128392	Tursiops truncatus	47.22	0.00e+00	1155.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence