iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-14	53.6	14	68

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++++ly +e+ + deL +++Gd++++   +  d  W+kg  + +g+ Gl+P+n+v++
   Q: 14   VKVFRALYTFEPRTPDELYFEEGDIIYIT--DMSDTSWWKG--TCKGRTGLIPSNYVAE 68
           57899***********************7..99********..8*************86 PP

Organism

Rattus norvegicus

Functional Description
(View)

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Protein Sequence
(Fasta)

MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTSWW KGTCKGRTGL 60
IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN GLDKAGSTAL YWACHGGHKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGCTGGGC TGTCTGCGGA GCTCGCTAGT CCCGGTGTCC CGCTTCGGGT TGCGCGCGGG 60
TCCGGAGCGG GCGCGGCTAG CGCAGGCTTG GCTCCCAGTT CCTGTCTGCG TGTGGGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001452--SH3_domain

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3

Pfam

PF12796--Ank_2
PF00018--SH3_1

PRINTS

PR01415--ANKYRIN
PR00452--SH3DOMAIN

SMART

SM00248--ANK
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome

KEGG

rno:259275

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001728	Ailuropoda melanoleuca	94.44	2.00e-111	394.00
IUUC-Apl-003751	Anas platyrhynchos	87.92	7.00e-106	375.00
IUUC-Aca-004876	Anolis carolinensis	92.06	6.00e-111	392.00
IUUC-Bta-012630	Bos taurus	95.45	8.00e-113	399.00
IUUC-Cel-018470	Caenorhabditis elegans	49.27	1.00e-50	192.00
IUUC-Cja-019917	Callithrix jacchus	96.46	3.00e-113	400.00
IUUC-Cfa-020190	Canis familiaris	96.74	2.00e-105	374.00
IUUC-Cpo-021650	Cavia porcellus	93.43	1.00e-109	388.00
IUUC-Csa-023311	Chlorocebus sabaeus	95.96	8.00e-113	399.00
IUUC-Cho-025043	Choloepus hoffmanni	86.14	8.00e-102	362.00
IUUC-Cin-025298	Ciona intestinalis	55.88	1.00e-53	202.00
IUUC-Csv-025890	Ciona savignyi	56.44	1.00e-60	226.00
IUUC-Dre-028036	Danio rerio	81.69	5.00e-100	356.00
IUUC-Dno-029567	Dasypus novemcinctus	95.96	8.00e-113	399.00
IUUC-Dor-031060	Dipodomys ordii	96.46	3.00e-113	400.00
IUUC-Eca-034406	Equus caballus	95.57	4.00e-115	406.00
IUUC-Fca-036234	Felis catus	95.53	2.00e-101	360.00
IUUC-Fal-037466	Ficedula albicollis	91.12	9.00e-111	392.00
IUUC-Gmo-039340	Gadus morhua	79.44	4.00e-100	357.00
IUUC-Gga-041127	Gallus gallus	92.52	5.00e-112	396.00
IUUC-Gac-042291	Gasterosteus aculeatus	80.37	3.00e-100	357.00
IUUC-Ggo-045142	Gorilla gorilla	95.45	8.00e-112	395.00
IUUC-Hsa-045670	Homo sapiens	95.45	8.00e-112	395.00
IUUC-Lch-050433	Latimeria chalumnae	85.98	2.00e-105	374.00
IUUC-Loc-052660	Lepisosteus oculatus	84.58	2.00e-105	374.00
IUUC-Laf-053692	Loxodonta africana	95.61	3.00e-115	407.00
IUUC-Mcc-054763	Macaca mulatta	95.96	8.00e-113	399.00
IUUC-Mga-059479	Meleagris gallopavo	92.55	5.00e-103	366.00
IUUC-Mmr-061426	Microcebus murinus	94.95	1.00e-111	395.00
IUUC-Mdo-062513	Monodelphis domestica	93.94	2.00e-111	394.00
IUUC-Mmu-063898	Mus musculus	98.99	9.00e-115	405.00
IUUC-Mpu-066606	Mustela putorius furo	97.04	7.00e-97	345.00
IUUC-Mlu-068187	Myotis lucifugus	93.66	8.00e-113	399.00
IUUC-Nle-069167	Nomascus leucogenys	95.96	8.00e-113	399.00
IUUC-Opr-070908	Ochotona princeps	95.54	2.00e-114	404.00
IUUC-Ont-072428	Oreochromis niloticus	82.71	2.00e-103	367.00
IUUC-Oan-072823	Ornithorhynchus anatinus	94.15	8.00e-114	402.00
IUUC-Ocu-074375	Oryctolagus cuniculus	96.97	8.00e-114	402.00
IUUC-Ola-086922	Oryzias latipes	83.18	2.00e-103	367.00
IUUC-Oga-088253	Otolemur garnettii	94.95	2.00e-111	394.00
IUUC-Oar-090217	Ovis aries	96.08	2.00e-115	407.00
IUUC-Ptr-091605	Pan troglodytes	95.45	8.00e-112	395.00
IUUC-Pan-092701	Papio anubis	95.96	8.00e-113	399.00
IUUC-Psi-093852	Pelodiscus sinensis	93.93	2.00e-114	404.00
IUUC-Pfo-096294	Poecilia formosa	80.84	1.00e-101	362.00
IUUC-Pva-102840	Pteropus vampyrus	74.77	3.00e-83	301.00
IUUC-Sha-106884	Sarcophilus harrisii	93.17	1.00e-112	398.00
IUUC-Sja-107861	Schizosaccharomyces japonicus	36.63	8.00e-11	59.30
IUUC-Ssc-115549	Sus scrofa	95.96	1.00e-112	398.00
IUUC-Tgu-116709	Taeniopygia guttata	91.12	9.00e-111	392.00
IUUC-Tru-118367	Takifugu rubripes	84.11	9.00e-105	372.00
IUUC-Tni-120613	Tetraodon nigroviridis	82.71	2.00e-102	364.00
IUUC-Tbe-128089	Tupaia belangeri	79.35	6.00e-81	292.00
IUUC-Vpa-130041	Vicugna pacos	73.17	2.00e-77	281.00
IUUC-Xtr-132694	Xenopus tropicalis	83.66	4.00e-101	360.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence