iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tni-120121

Ensembl Protein ID

ENSTNIP00000015231.1

UniProt Accession

H3D3Z3; H3D3Z3_TETNG

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000012264.1	ENSTNIT00000015435.1	ENSTNIP00000015231.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	54.64	2.00e-135	480.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Tetraodon nigroviridis

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MLLRQSPVQS RQTRGPEVKA RITAAFTELE TLSPQHPSPP LRALLTDMYP EESRGSRGVA 60
NVDYLEGPYD YAAPTAATTP LYTHSSSSCY SAPLDAHGPP SDGSLHSLGS GPTSPLVFVP 120

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Nucleotide Sequence
(Fasta)

ATGTTGCTCA GGCAGAGTCC GGTGCAGAGC AGGCAGACCC GAGGACCAGA AGTCAAAGCC 60
AGGATTACCG CAGCCTTCAC AGAGCTGGAG ACCCTCTCCC CGCAGCACCC CTCGCCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	60.41	6.00e-128	450.00
IUUC-Apl-003688	Anas platyrhynchos	52.13	1.00e-132	466.00
IUUC-Aca-005222	Anolis carolinensis	50.09	8.00e-135	474.00
IUUC-Ame-010731	Astyanax mexicanus	61.47	1.00e-165	576.00
IUUC-Bta-013112	Bos taurus	59.79	2.00e-128	452.00
IUUC-Cja-019408	Callithrix jacchus	55.13	1.00e-129	456.00
IUUC-Cfa-020694	Canis familiaris	56.08	5.00e-130	457.00
IUUC-Cpo-021426	Cavia porcellus	54.40	4.00e-125	441.00
IUUC-Csa-023736	Chlorocebus sabaeus	56.82	1.00e-131	462.00
IUUC-Dre-027698	Danio rerio	59.39	1.00e-165	576.00
IUUC-Dno-029477	Dasypus novemcinctus	60.78	8.00e-126	444.00
IUUC-Dor-030572	Dipodomys ordii	59.95	2.00e-122	432.00
IUUC-Ete-032849	Echinops telfairi	46.53	3.00e-84	305.00
IUUC-Eca-033605	Equus caballus	49.47	5.00e-130	457.00
IUUC-Eeu-034683	Erinaceus europaeus	55.00	4.00e-55	208.00
IUUC-Fca-035928	Felis catus	60.98	3.00e-127	447.00
IUUC-Fal-036754	Ficedula albicollis	52.59	5.00e-143	501.00
IUUC-Gmo-038872	Gadus morhua	69.81	3.00e-162	564.00
IUUC-Gga-040988	Gallus gallus	52.51	2.00e-140	492.00
IUUC-Gac-042015	Gasterosteus aculeatus	69.50	0.00e+00	700.00
IUUC-Ggo-044749	Gorilla gorilla	56.56	2.00e-129	456.00
IUUC-Hsa-046944	Homo sapiens	55.88	6.00e-129	454.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	57.25	2.00e-126	445.00
IUUC-Loc-052414	Lepisosteus oculatus	61.06	5.00e-175	607.00
IUUC-Lma-052950	Leptosphaeria maculans	40.00	2.30e+00	28.10
IUUC-Mcc-054781	Macaca mulatta	56.56	2.00e-129	456.00
IUUC-Meu-056232	Macropus eugenii	50.73	4.00e-127	448.00
IUUC-Mla-058982	Melampsora laricipopulina	30.77	5.00e-02	32.00
IUUC-Mga-059319	Meleagris gallopavo	52.33	4.00e-140	491.00
IUUC-Mmr-061636	Microcebus murinus	46.92	3.00e-55	208.00
IUUC-Mdo-062661	Monodelphis domestica	52.20	7.00e-133	467.00
IUUC-Mmu-063330	Mus musculus	54.95	2.00e-127	449.00
IUUC-Mpu-065757	Mustela putorius furo	49.91	2.00e-132	466.00
IUUC-Mlu-067712	Myotis lucifugus	56.33	3.00e-129	454.00
IUUC-Nle-069283	Nomascus leucogenys	56.56	1.00e-129	456.00
IUUC-Opr-070391	Ochotona princeps	58.76	5.00e-127	447.00
IUUC-Ont-071369	Oreochromis niloticus	71.07	0.00e+00	715.00
IUUC-Oan-073734	Ornithorhynchus anatinus	42.68	9.00e-58	216.00
IUUC-Ocu-074292	Oryctolagus cuniculus	55.51	6.00e-129	454.00
IUUC-Ola-087052	Oryzias latipes	74.31	0.00e+00	730.00
IUUC-Oga-088586	Otolemur garnettii	55.03	3.00e-127	448.00
IUUC-Oar-090156	Ovis aries	58.73	8.00e-127	447.00
IUUC-Ptr-091321	Pan troglodytes	56.56	2.00e-129	456.00
IUUC-Pan-092851	Papio anubis	56.56	2.00e-129	456.00
IUUC-Psi-093434	Pelodiscus sinensis	52.12	2.00e-138	485.00
IUUC-Pfo-097379	Poecilia formosa	70.86	0.00e+00	745.00
IUUC-Pab-097735	Pongo abelii	56.56	2.00e-129	456.00
IUUC-Pva-102125	Pteropus vampyrus	50.36	1.00e-129	456.00
IUUC-Rno-106121	Rattus norvegicus	54.95	4.00e-127	448.00
IUUC-Sha-107547	Sarcophilus harrisii	51.08	1.00e-131	463.00
IUUC-Sar-113650	Sorex araneus	44.42	5.00e-76	278.00
IUUC-Tgu-117175	Taeniopygia guttata	52.08	1.00e-143	503.00
IUUC-Tru-117545	Takifugu rubripes	86.70	0.00e+00	895.00
IUUC-Tsy-119586	Tarsius syrichta	50.00	1.00e-111	396.00
IUUC-Tbe-127548	Tupaia belangeri	50.64	2.00e-97	349.00
IUUC-Ttr-128374	Tursiops truncatus	52.81	7.00e-117	414.00
IUUC-Vpa-130464	Vicugna pacos	46.97	5.00e-81	294.00
IUUC-Xtr-132171	Xenopus tropicalis	52.06	1.00e-131	463.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence