iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cja-019426

UUCD1 version

UUC-CaJ-00488

Ensembl Protein ID

ENSCJAP00000020431.2

UniProt Accession

F7ES31; F7ES31_CALJA

Genbank Protein ID

JAB08622.1; JAB19709.1; JAB25509.1; JAB37128.1; JAB51794.1

Protein Name

TNF receptor-associated factor 6

Genbank Nucleotide ID

ACFV01039737; GAMS01003427; GAMR01008423; GAMQ01004723; GAMP01000961

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000011070.2	ENSCJAT00000021586.2	ENSCJAP00000020431.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.40e-07	30.1	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC GAMASSCSAA TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGAAAGC GGAAGCACTG GCGTCCGCAG CTGGGTTTGG CCTGCGGGCG GCCAGCGGAG 60
GTGGAGACGT TGCTTTTTGG ACCCAGAGTG TGACGTCGGA GCAGTCTCGT CTCGGAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

cjc:100395364

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	90.02	0.00e+00	957.00
IUUC-Apl-004062	Anas platyrhynchos	72.41	0.00e+00	827.00
IUUC-Aca-004636	Anolis carolinensis	70.80	0.00e+00	768.00
IUUC-Ame-011682	Astyanax mexicanus	53.60	1.00e-163	569.00
IUUC-Bta-012692	Bos taurus	88.56	0.00e+00	971.00
IUUC-Bci-013998	Botrytis cinerea	23.64	3.00e-13	69.70
IUUC-Cfa-020948	Canis familiaris	89.78	0.00e+00	850.00
IUUC-Cpo-021378	Cavia porcellus	88.95	0.00e+00	956.00
IUUC-Csa-024045	Chlorocebus sabaeus	95.03	0.00e+00	1009.00
IUUC-Cho-024973	Choloepus hoffmanni	75.40	3.00e-108	385.00
IUUC-Csv-026300	Ciona savignyi	39.92	5.00e-47	180.00
IUUC-Dre-027557	Danio rerio	56.35	3.00e-175	608.00
IUUC-Dno-030032	Dasypus novemcinctus	84.66	1.00e-145	508.00
IUUC-Dor-030790	Dipodomys ordii	91.08	0.00e+00	969.00
IUUC-Dse-031478	Dothistroma septosporum	24.02	1.00e-10	61.60
IUUC-Dme-031921	Drosophila melanogaster	26.65	4.00e-39	155.00
IUUC-Ete-032952	Echinops telfairi	86.73	7.00e-166	577.00
IUUC-Eca-033924	Equus caballus	85.45	0.00e+00	869.00
IUUC-Eeu-034734	Erinaceus europaeus	85.88	0.00e+00	878.00
IUUC-Fca-036222	Felis catus	82.47	0.00e+00	836.00
IUUC-Fal-036834	Ficedula albicollis	73.67	0.00e+00	733.00
IUUC-Fox-037935	Fusarium oxysporum	28.97	4.00e-21	95.90
IUUC-Gmo-039061	Gadus morhua	57.00	5.00e-89	321.00
IUUC-Ggr-040084	Gaeumannomyces graminis	29.28	9.00e-14	72.00
IUUC-Gga-040599	Gallus gallus	73.25	0.00e+00	835.00
IUUC-Gac-041977	Gasterosteus aculeatus	56.45	6.00e-167	580.00
IUUC-Ggo-044508	Gorilla gorilla	88.57	0.00e+00	918.00
IUUC-Hsa-046349	Homo sapiens	95.41	0.00e+00	1040.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	91.51	0.00e+00	993.00
IUUC-Lch-049821	Latimeria chalumnae	67.08	0.00e+00	752.00
IUUC-Lpe-051025	Leersia perrieri	25.86	9.00e-07	47.80
IUUC-Loc-051995	Lepisosteus oculatus	59.20	2.00e-179	622.00
IUUC-Laf-054115	Loxodonta africana	85.21	0.00e+00	940.00
IUUC-Mcc-055298	Macaca mulatta	94.65	0.00e+00	1003.00
IUUC-Mor-057263	Magnaporthe oryzae	30.09	2.00e-17	84.00
IUUC-Mpo-057517	Magnaporthe poae	28.96	1.00e-14	75.10
IUUC-Mga-059340	Meleagris gallopavo	72.66	0.00e+00	812.00
IUUC-Mvi-060553	Microbotryum violaceum	27.23	6.00e-14	72.00
IUUC-Mmr-061063	Microcebus murinus	92.68	0.00e+00	977.00
IUUC-Mdo-062075	Monodelphis domestica	80.37	0.00e+00	905.00
IUUC-Mmu-063780	Mus musculus	88.49	0.00e+00	915.00
IUUC-Mac-064529	Musa acuminata	24.02	2.00e-09	56.60
IUUC-Mpu-065748	Mustela putorius furo	90.02	0.00e+00	969.00
IUUC-Mlu-067888	Myotis lucifugus	88.27	0.00e+00	949.00
IUUC-Nle-069234	Nomascus leucogenys	95.41	0.00e+00	1013.00
IUUC-Opr-070393	Ochotona princeps	95.31	1.00e-121	430.00
IUUC-Ont-072459	Oreochromis niloticus	54.42	1.00e-176	613.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.99	0.00e+00	905.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.74	0.00e+00	977.00
IUUC-Obr-076500	Oryza brachyantha	33.33	1.00e-08	53.90
IUUC-Ogl-077406	Oryza glaberrima	25.86	6.00e-08	51.60
IUUC-Oin-079307	Oryza indica	25.86	7.00e-08	51.60
IUUC-Olo-080508	Oryza longistaminata	26.44	3.00e-08	52.80
IUUC-Ome-081315	Oryza meridionalis	24.06	1.00e-07	50.80
IUUC-Oni-082966	Oryza nivara	22.94	2.00e-06	47.00
IUUC-Osa-085780	Oryza sativa	25.86	6.00e-08	51.60
IUUC-Ola-087319	Oryzias latipes	58.94	3.00e-90	325.00
IUUC-Olu-087748	Ostreococcus lucimarinus	22.36	1.00e-09	57.00
IUUC-Oga-087936	Otolemur garnettii	89.72	0.00e+00	967.00
IUUC-Oar-089379	Ovis aries	87.82	0.00e+00	969.00
IUUC-Ptr-090758	Pan troglodytes	95.79	0.00e+00	1013.00
IUUC-Pan-092590	Papio anubis	94.84	0.00e+00	1004.00
IUUC-Psi-093948	Pelodiscus sinensis	72.39	0.00e+00	811.00
IUUC-Pma-094434	Petromyzon marinus	43.09	4.00e-125	441.00
IUUC-Pfo-096912	Poecilia formosa	56.05	1.00e-168	586.00
IUUC-Pab-097651	Pongo abelii	95.79	0.00e+00	1013.00
IUUC-Pca-100958	Procavia capensis	87.70	0.00e+00	699.00
IUUC-Pva-103247	Pteropus vampyrus	92.06	4.00e-131	461.00
IUUC-Pte-104279	Pyrenophora teres	26.48	6.00e-13	69.70
IUUC-Rno-104994	Rattus norvegicus	86.42	0.00e+00	924.00
IUUC-Sha-106494	Sarcophilus harrisii	82.26	0.00e+00	914.00
IUUC-Sar-113375	Sorex araneus	88.24	0.00e+00	929.00
IUUC-Sre-115218	Sporisorium reilianum	27.31	5.00e-16	79.30
IUUC-Ssc-115417	Sus scrofa	88.54	0.00e+00	971.00
IUUC-Tgu-117232	Taeniopygia guttata	72.48	0.00e+00	786.00
IUUC-Tru-118321	Takifugu rubripes	53.23	1.00e-165	576.00
IUUC-Tni-120475	Tetraodon nigroviridis	53.50	3.00e-165	574.00
IUUC-Tbe-127719	Tupaia belangeri	80.87	0.00e+00	831.00
IUUC-Ttr-129264	Tursiops truncatus	89.72	2.00e-127	449.00
IUUC-Uma-129620	Ustilago maydis	27.78	4.00e-18	86.70
IUUC-Vpa-130244	Vicugna pacos	89.33	1.00e-129	456.00
IUUC-Vvi-131070	Vitis vinifera	24.56	9.00e-09	54.30
IUUC-Xtr-131948	Xenopus tropicalis	65.59	0.00e+00	752.00
IUUC-Xma-133132	Xiphophorus maculatus	56.43	3.00e-170	591.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence