iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092590

Ensembl Protein ID

ENSPANP00000004422.1

UniProt Accession

A0A096MX12; A0A096MX12_PAPAN

Genbank Protein ID

ENSPANP00000004422

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01067728

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000004746.1	ENSPANT00000008646.1	ENSPANP00000004422.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.90e-07	30.1	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC VAMASSCSAA TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAAGTGAT AATCAAGTTA CTATGAGTCT GCTAAACTGT GAAAACAGCT GTGGATCCAG 60
CCAGTCTGAA AGTGACTGCT GTGTGGCCAT GGCCAGTTCC TGTAGCGCTG CAACAAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	90.76	0.00e+00	951.00
IUUC-Apl-004062	Anas platyrhynchos	72.23	0.00e+00	825.00
IUUC-Aca-004636	Anolis carolinensis	70.62	0.00e+00	770.00
IUUC-Ame-011682	Astyanax mexicanus	53.23	4.00e-162	564.00
IUUC-Bta-012692	Bos taurus	88.56	0.00e+00	967.00
IUUC-Bci-013998	Botrytis cinerea	25.24	4.00e-14	72.80
IUUC-Bra-017948	Brassica rapa	28.08	4.00e-09	56.60
IUUC-Cja-019426	Callithrix jacchus	94.07	0.00e+00	995.00
IUUC-Cfa-020948	Canis familiaris	89.16	0.00e+00	835.00
IUUC-Cpo-021378	Cavia porcellus	88.58	0.00e+00	943.00
IUUC-Csa-024045	Chlorocebus sabaeus	99.81	0.00e+00	1058.00
IUUC-Cho-024973	Choloepus hoffmanni	75.00	3.00e-105	375.00
IUUC-Csv-026300	Ciona savignyi	39.53	2.00e-46	179.00
IUUC-Dre-027557	Danio rerio	56.72	2.00e-176	612.00
IUUC-Dno-030032	Dasypus novemcinctus	83.79	1.00e-141	495.00
IUUC-Dor-030790	Dipodomys ordii	91.25	0.00e+00	971.00
IUUC-Dme-031921	Drosophila melanogaster	26.97	2.00e-38	153.00
IUUC-Ete-032952	Echinops telfairi	88.44	8.00e-170	590.00
IUUC-Eca-033924	Equus caballus	84.16	0.00e+00	860.00
IUUC-Eeu-034734	Erinaceus europaeus	86.23	0.00e+00	888.00
IUUC-Fca-036222	Felis catus	82.84	0.00e+00	838.00
IUUC-Fal-036834	Ficedula albicollis	73.46	0.00e+00	732.00
IUUC-Fox-037935	Fusarium oxysporum	29.44	7.00e-21	95.10
IUUC-Gmo-039061	Gadus morhua	57.30	2.00e-88	320.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.38	4.00e-13	69.70
IUUC-Gga-040599	Gallus gallus	72.84	0.00e+00	835.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.66	9.00e-167	580.00
IUUC-Ggo-044508	Gorilla gorilla	90.84	0.00e+00	941.00
IUUC-Hsa-046349	Homo sapiens	98.28	0.00e+00	1078.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	91.13	0.00e+00	981.00
IUUC-Lch-049821	Latimeria chalumnae	67.08	0.00e+00	753.00
IUUC-Lpe-051025	Leersia perrieri	25.29	1.00e-06	47.00
IUUC-Loc-051995	Lepisosteus oculatus	60.34	0.00e+00	630.00
IUUC-Laf-054115	Loxodonta africana	85.21	0.00e+00	931.00
IUUC-Mcc-055298	Macaca mulatta	99.81	0.00e+00	1058.00
IUUC-Mor-057263	Magnaporthe oryzae	31.02	8.00e-19	88.60
IUUC-Mpo-057517	Magnaporthe poae	28.96	5.00e-15	75.90
IUUC-Mga-059340	Meleagris gallopavo	72.66	0.00e+00	811.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	7.00e-15	75.50
IUUC-Mmr-061063	Microcebus murinus	91.37	0.00e+00	958.00
IUUC-Mdo-062075	Monodelphis domestica	79.85	0.00e+00	905.00
IUUC-Mmu-063780	Mus musculus	87.55	0.00e+00	900.00
IUUC-Mpu-065748	Mustela putorius furo	88.91	0.00e+00	956.00
IUUC-Mlu-067888	Myotis lucifugus	88.27	0.00e+00	941.00
IUUC-Ncr-068632	Neurospora crassa	26.15	6.00e-17	82.40
IUUC-Nle-069234	Nomascus leucogenys	98.28	0.00e+00	1049.00
IUUC-Opr-070393	Ochotona princeps	95.77	3.00e-122	432.00
IUUC-Ont-072459	Oreochromis niloticus	54.24	2.00e-175	608.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.07	0.00e+00	896.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.57	0.00e+00	961.00
IUUC-Oba-075457	Oryza barthii	27.01	2.00e-08	53.10
IUUC-Obr-076500	Oryza brachyantha	26.40	4.00e-10	58.50
IUUC-Ogl-077406	Oryza glaberrima	27.01	1.00e-08	53.50
IUUC-Ogu-078803	Oryza glumaepatula	26.49	8.00e-09	54.70
IUUC-Oin-079307	Oryza indica	27.01	1.00e-08	53.50
IUUC-Olo-080508	Oryza longistaminata	27.59	7.00e-09	54.70
IUUC-Ome-081315	Oryza meridionalis	27.01	7.00e-09	55.10
IUUC-Oni-082966	Oryza nivara	26.49	1.00e-08	54.30
IUUC-Oru-085055	Oryza rufipogon	26.49	1.00e-08	54.30
IUUC-Osa-085780	Oryza sativa	27.01	1.00e-08	53.90
IUUC-Ola-087319	Oryzias latipes	59.32	1.00e-91	330.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.14	1.00e-10	60.50
IUUC-Oga-087936	Otolemur garnettii	89.72	0.00e+00	956.00
IUUC-Oar-089379	Ovis aries	88.38	0.00e+00	973.00
IUUC-Ptr-090758	Pan troglodytes	98.66	0.00e+00	1048.00
IUUC-Psi-093948	Pelodiscus sinensis	71.12	0.00e+00	801.00
IUUC-Pma-094434	Petromyzon marinus	50.72	9.00e-76	277.00
IUUC-Pfo-096912	Poecilia formosa	52.56	2.00e-168	585.00
IUUC-Pab-097651	Pongo abelii	98.66	0.00e+00	1051.00
IUUC-Pca-100958	Procavia capensis	89.54	0.00e+00	715.00
IUUC-Pva-103247	Pteropus vampyrus	92.46	3.00e-130	458.00
IUUC-Rno-104994	Rattus norvegicus	86.23	0.00e+00	913.00
IUUC-Sha-106494	Sarcophilus harrisii	83.05	0.00e+00	922.00
IUUC-Sar-113375	Sorex araneus	87.29	0.00e+00	924.00
IUUC-Sre-115218	Sporisorium reilianum	27.63	3.00e-15	77.00
IUUC-Ssc-115417	Sus scrofa	88.35	0.00e+00	959.00
IUUC-Tgu-117232	Taeniopygia guttata	72.48	0.00e+00	788.00
IUUC-Tru-118321	Takifugu rubripes	53.42	3.00e-167	581.00
IUUC-Tni-120475	Tetraodon nigroviridis	54.60	5.00e-166	577.00
IUUC-Tbe-127719	Tupaia belangeri	80.68	0.00e+00	825.00
IUUC-Ttr-129264	Tursiops truncatus	88.54	2.00e-124	439.00
IUUC-Uma-129620	Ustilago maydis	28.06	6.00e-17	82.80
IUUC-Vpa-130244	Vicugna pacos	88.14	1.00e-126	446.00
IUUC-Xtr-131948	Xenopus tropicalis	64.87	0.00e+00	747.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence