iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013399

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02049347

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019853.5	ENSBTAT00000026451.5	ENSBTAP00000026451.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.80e-130	434.0	397	729

Active Site

Position(s)	Description	Evidence
698	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 397  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 484
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   d++   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 485  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DTTGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 569
           ***********************************99...88887.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds++++wFw+++e f++e r+++LqFv
   Q: 570  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNVVKWFWKAVEFFDEERRARLLQFV 657
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 658  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 729
           **********************************************************************76 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

VLCAKNLVKK DFFRLPDPFA KVVVDGSGQC HSTDTVKNTL DPKWNQHYDL YIGKSDSVTI 60
SVWNHKKIHK KQGAGFLGCV RLLSNAINRL KDTGYQRLDL CKLGPNDNDT VRGQIVVSLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTACTCTGTG CAAAAAACTT GGTGAAAAAG GATTTTTTCC GTAAGTAAAT TAACTTTAAA 60
TCTTGTATAT TGTATGTAGA TTTTTTTGCA AAGCATTTTC AGAATTGTCT GGTTTAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	99.45	0.00e+00	1490.00
IUUC-Apl-003513	Anas platyrhynchos	97.68	0.00e+00	1476.00
IUUC-Aca-005358	Anolis carolinensis	97.15	0.00e+00	1467.00
IUUC-Ame-011320	Astyanax mexicanus	87.58	0.00e+00	1358.00
IUUC-Cja-019355	Callithrix jacchus	99.32	0.00e+00	1489.00
IUUC-Cpo-022200	Cavia porcellus	99.59	0.00e+00	1491.00
IUUC-Cin-025126	Ciona intestinalis	66.58	0.00e+00	964.00
IUUC-Csv-026339	Ciona savignyi	64.75	0.00e+00	994.00
IUUC-Dre-027650	Danio rerio	90.91	0.00e+00	1407.00
IUUC-Dno-029534	Dasypus novemcinctus	99.45	0.00e+00	1492.00
IUUC-Dme-031740	Drosophila melanogaster	71.91	5.00e-172	598.00
IUUC-Ete-032715	Echinops telfairi	93.84	0.00e+00	1403.00
IUUC-Eca-033580	Equus caballus	99.73	0.00e+00	1493.00
IUUC-Eeu-034945	Erinaceus europaeus	97.85	0.00e+00	1391.00
IUUC-Fal-037275	Ficedula albicollis	97.28	0.00e+00	1465.00
IUUC-Gga-041060	Gallus gallus	94.16	0.00e+00	1402.00
IUUC-Gac-041295	Gasterosteus aculeatus	91.73	0.00e+00	1393.00
IUUC-Hsa-046726	Homo sapiens	99.45	0.00e+00	1491.00
IUUC-Lch-050026	Latimeria chalumnae	95.52	0.00e+00	1442.00
IUUC-Loc-051760	Lepisosteus oculatus	88.06	0.00e+00	1376.00
IUUC-Laf-053753	Loxodonta africana	99.59	0.00e+00	1493.00
IUUC-Mcc-054815	Macaca mulatta	99.18	0.00e+00	1488.00
IUUC-Meu-056436	Macropus eugenii	75.31	0.00e+00	1068.00
IUUC-Mmr-060806	Microcebus murinus	99.73	0.00e+00	1495.00
IUUC-Mdo-062805	Monodelphis domestica	97.40	0.00e+00	1464.00
IUUC-Mmu-064034	Mus musculus	99.18	0.00e+00	1485.00
IUUC-Mpu-066762	Mustela putorius furo	99.45	0.00e+00	1491.00
IUUC-Mlu-066981	Myotis lucifugus	99.59	0.00e+00	1493.00
IUUC-Nle-069804	Nomascus leucogenys	99.45	0.00e+00	1491.00
IUUC-Opr-070591	Ochotona princeps	93.15	0.00e+00	1393.00
IUUC-Ont-071239	Oreochromis niloticus	92.55	0.00e+00	1400.00
IUUC-Oan-072699	Ornithorhynchus anatinus	94.42	0.00e+00	1462.00
IUUC-Ocu-074913	Oryctolagus cuniculus	99.73	0.00e+00	1494.00
IUUC-Ola-086597	Oryzias latipes	85.36	0.00e+00	1282.00
IUUC-Oga-089116	Otolemur garnettii	95.90	0.00e+00	1428.00
IUUC-Oar-089366	Ovis aries	100.00	0.00e+00	1502.00
IUUC-Ptr-091382	Pan troglodytes	99.45	0.00e+00	1491.00
IUUC-Psi-093298	Pelodiscus sinensis	97.27	0.00e+00	1456.00
IUUC-Pma-094354	Petromyzon marinus	73.71	0.00e+00	1106.00
IUUC-Pfo-096071	Poecilia formosa	89.26	0.00e+00	1389.00
IUUC-Pab-098682	Pongo abelii	99.45	0.00e+00	1491.00
IUUC-Pca-100516	Procavia capensis	90.12	0.00e+00	637.00
IUUC-Pva-102754	Pteropus vampyrus	97.67	0.00e+00	1459.00
IUUC-Rno-105600	Rattus norvegicus	99.06	0.00e+00	1288.00
IUUC-Sha-107144	Sarcophilus harrisii	97.06	0.00e+00	1352.00
IUUC-Sar-113122	Sorex araneus	88.36	0.00e+00	1279.00
IUUC-Tgu-117112	Taeniopygia guttata	96.88	0.00e+00	1464.00
IUUC-Tru-118497	Takifugu rubripes	89.01	0.00e+00	1341.00
IUUC-Tsy-118819	Tarsius syrichta	98.06	0.00e+00	1038.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.46	0.00e+00	1179.00
IUUC-Tme-126897	Tuber melanosporum	39.32	5.00e-151	528.00
IUUC-Tbe-127371	Tupaia belangeri	88.56	0.00e+00	1193.00
IUUC-Ttr-129305	Tursiops truncatus	92.82	0.00e+00	1293.00
IUUC-Vpa-130591	Vicugna pacos	88.49	0.00e+00	1298.00
IUUC-Xtr-132979	Xenopus tropicalis	76.93	0.00e+00	1104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence