iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021552

Ensembl Protein ID

ENSCPOP00000003358.2

UniProt Accession

H0V1J2; H0V1J2_CAVPO

Genbank Protein ID

ENSCPOP00000003358

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAKN02042168

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000003718.3	ENSCPOT00000003762.2	ENSCPOP00000003358.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.80e-19	69.0	1196	1254

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek...slveCekCrewfHpaClkls.....veeelpnsekwiCpkCr 52
           ++C++C++++ed++   ++++C +C++w+H++C +ls     + + lp+s  ++C  C 
   Q: 1196 NYCPICTRCYEDNDyesKMMQCAQCDHWVHAKCEGLSdedyeILSGLPDSVLYTCGPCA 1254
           79**********98888*****************************************7 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

CPVAAPGGAC PRTVHFPGRS VLRILDGRAK RGAAGPGLER RVRVALRRGS GAAGPGGAEP 60
GEDTALLRLL GLRRGLRRLR RLWAGPRLQR MPEEESSDGE SDDEEFQGFH SDEDVAPSSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCCTGTAG CGGCCCCTGG TGGTGCATGT CCGCGCACCG TGCACTTTCC GGGGCGCTCC 60
GTTCTCCGAA GTCATTTCTC AAGATCTCAG TGTCCTGAAC AACTTCACAA CAGGCCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	89.62	0.00e+00	3137.00
IUUC-Aca-004718	Anolis carolinensis	56.17	0.00e+00	1448.00
IUUC-Ame-010705	Astyanax mexicanus	42.86	0.00e+00	882.00
IUUC-Bta-013578	Bos taurus	91.64	0.00e+00	2850.00
IUUC-Cja-019138	Callithrix jacchus	88.34	0.00e+00	3317.00
IUUC-Cfa-020020	Canis familiaris	90.54	0.00e+00	3087.00
IUUC-Csa-024216	Chlorocebus sabaeus	89.67	0.00e+00	2424.00
IUUC-Cho-024565	Choloepus hoffmanni	77.06	2.00e-165	577.00
IUUC-Cin-025724	Ciona intestinalis	54.83	7.00e-96	345.00
IUUC-Dno-029583	Dasypus novemcinctus	91.34	0.00e+00	2976.00
IUUC-Dor-030903	Dipodomys ordii	84.76	0.00e+00	2120.00
IUUC-Dme-032023	Drosophila melanogaster	47.28	1.00e-92	336.00
IUUC-Eca-034026	Equus caballus	92.85	0.00e+00	1892.00
IUUC-Eeu-034687	Erinaceus europaeus	88.76	0.00e+00	1064.00
IUUC-Fca-036311	Felis catus	89.54	0.00e+00	3181.00
IUUC-Gmo-039265	Gadus morhua	44.81	0.00e+00	793.00
IUUC-Gac-042202	Gasterosteus aculeatus	47.84	0.00e+00	717.00
IUUC-Ggo-044791	Gorilla gorilla	90.58	0.00e+00	2065.00
IUUC-Hsa-046988	Homo sapiens	89.21	0.00e+00	2370.00
IUUC-Itr-048907	Ictidomys tridecemlineatus	90.93	0.00e+00	3312.00
IUUC-Laf-053703	Loxodonta africana	90.62	0.00e+00	2142.00
IUUC-Mcc-054782	Macaca mulatta	88.71	0.00e+00	2417.00
IUUC-Meu-056046	Macropus eugenii	77.69	0.00e+00	1799.00
IUUC-Mmr-061316	Microcebus murinus	86.48	0.00e+00	2955.00
IUUC-Mdo-062648	Monodelphis domestica	78.01	0.00e+00	1951.00
IUUC-Mmu-063579	Mus musculus	88.85	0.00e+00	3235.00
IUUC-Mpu-066710	Mustela putorius furo	90.07	0.00e+00	3110.00
IUUC-Mlu-067559	Myotis lucifugus	88.08	0.00e+00	2367.00
IUUC-Nle-070085	Nomascus leucogenys	87.97	0.00e+00	2104.00
IUUC-Opr-071148	Ochotona princeps	86.84	0.00e+00	3137.00
IUUC-Ont-071626	Oreochromis niloticus	47.83	0.00e+00	750.00
IUUC-Ocu-074475	Oryctolagus cuniculus	89.63	0.00e+00	3229.00
IUUC-Ogl-077851	Oryza glaberrima	34.43	1.00e-24	108.00
IUUC-Oin-079802	Oryza indica	29.44	8.00e-20	92.00
IUUC-Osa-085421	Oryza sativa	34.43	2.00e-24	107.00
IUUC-Oga-088140	Otolemur garnettii	90.25	0.00e+00	3159.00
IUUC-Oar-089447	Ovis aries	91.54	0.00e+00	1969.00
IUUC-Ptr-090902	Pan troglodytes	89.03	0.00e+00	2373.00
IUUC-Pan-091930	Papio anubis	89.61	0.00e+00	2437.00
IUUC-Ppa-095221	Physcomitrella patens	35.55	6.00e-29	122.00
IUUC-Pfo-096884	Poecilia formosa	44.36	0.00e+00	858.00
IUUC-Pab-098404	Pongo abelii	92.20	0.00e+00	1088.00
IUUC-Pca-100949	Procavia capensis	78.77	0.00e+00	1175.00
IUUC-Pva-102634	Pteropus vampyrus	90.36	0.00e+00	3194.00
IUUC-Rno-105870	Rattus norvegicus	88.47	0.00e+00	3317.00
IUUC-Sar-113289	Sorex araneus	92.26	0.00e+00	1214.00
IUUC-Ssc-115509	Sus scrofa	91.50	0.00e+00	2929.00
IUUC-Tru-117736	Takifugu rubripes	44.39	0.00e+00	807.00
IUUC-Tbe-127825	Tupaia belangeri	83.93	0.00e+00	1370.00
IUUC-Ttr-128754	Tursiops truncatus	88.87	0.00e+00	1160.00
IUUC-Xtr-132838	Xenopus tropicalis	44.40	0.00e+00	1034.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence