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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063408
UUCD1 version UUC-MuM-00431
Ensembl Protein ID ENSMUSP00000061305.9
UniProt Accession Q5BJ29; Q6ZQ36; FBXL7_MOUSE
Genbank Protein ID BAC98037.1; AAH91646.1
Protein Name F-box/LRR-repeat protein 7; F-box and leucine-rich repeat protein 7
Genbank Nucleotide ID AK129227; BC091646
Gene Name Fbxl7; Kiaa0840
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000043556.9 ENSMUST00000059204.9 ENSMUSP00000061305.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 3.00e-08 35.0 71 157
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 64   rgpsaaakpkaglrseaaaapapapaptp....tpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           rg s+++   +g       +p p+    p    +   + ++ ++drlp++ +v+i+++l++++l+r+arvcrrw++la +++lw+t+
   Q: 71   RGSSTSSSSITGETVAMVHSPPPTRLTHPlirlASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 157
           5555555555555555555555554444411112334567889********************************99999****997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.
Protein Sequence
(Fasta)
MGANNGKQYG SEGKGSSSVS SDVSSSTDHT PTKAQRNVAT SEDSDLSMRT LSTPSPALIC 60
PPTLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063408|E3,F-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCGCGA ACAATGGCAA ACAGTACGGC AGTGAGGGTG AGTGGGCCGA ACGTACCCCC 60
TCCCCCGACT CCCGGATCGC GCCCCCTCCC TTTCCTCTCG CACACAGCTC AGGCGCACCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063408|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0433--Leucine-rich repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF13516--LRR_6
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0008283--P:cell proliferation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:448987
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002298 Ailuropoda melanoleuca 97.55 0.00e+00 885.00
IUUC-Apl-003410 Anas platyrhynchos 95.99 0.00e+00 877.00
IUUC-Aca-004422 Anolis carolinensis 91.65 0.00e+00 882.00
IUUC-Aly-006311 Arabidopsis lyrata 27.01 1.00e-27 118.00
IUUC-Ago-007947 Ashbya gossypii 26.29 9.00e-24 106.00
IUUC-Afl-008576 Aspergillus flavus 26.61 3.00e-26 114.00
IUUC-Aor-010050 Aspergillus oryzae 26.61 2.00e-26 114.00
IUUC-Ame-010878 Astyanax mexicanus 82.74 0.00e+00 741.00
IUUC-Bgr-012097 Blumeria graminis 26.20 2.00e-27 118.00
IUUC-Bta-013145 Bos taurus 97.55 0.00e+00 887.00
IUUC-Bra-016671 Brassica rapa 30.88 4.00e-29 122.00
IUUC-Cja-019612 Callithrix jacchus 97.55 0.00e+00 883.00
IUUC-Cfa-020920 Canis familiaris 87.05 0.00e+00 797.00
IUUC-Cpo-022293 Cavia porcellus 97.33 0.00e+00 886.00
IUUC-Csa-024100 Chlorocebus sabaeus 98.87 0.00e+00 884.00
IUUC-Dre-028464 Danio rerio 81.30 0.00e+00 761.00
IUUC-Dno-028849 Dasypus novemcinctus 96.85 0.00e+00 875.00
IUUC-Dor-030835 Dipodomys ordii 88.40 5.00e-90 325.00
IUUC-Dme-031686 Drosophila melanogaster 49.21 7.00e-109 388.00
IUUC-Eca-034259 Equus caballus 97.70 0.00e+00 925.00
IUUC-Fca-035850 Felis catus 97.52 0.00e+00 877.00
IUUC-Fal-037009 Ficedula albicollis 95.32 0.00e+00 919.00
IUUC-Fox-037823 Fusarium oxysporum 26.07 6.00e-34 139.00
IUUC-Gmo-038560 Gadus morhua 72.85 2.00e-100 358.00
IUUC-Gga-040391 Gallus gallus 95.55 0.00e+00 874.00
IUUC-Gac-041464 Gasterosteus aculeatus 70.93 0.00e+00 656.00
IUUC-Ggo-044556 Gorilla gorilla 98.89 0.00e+00 892.00
IUUC-Hsa-046685 Homo sapiens 98.37 0.00e+00 938.00
IUUC-Itr-048013 Ictidomys tridecemlineatus 98.37 0.00e+00 939.00
IUUC-Lch-050268 Latimeria chalumnae 90.42 0.00e+00 808.00
IUUC-Loc-051910 Lepisosteus oculatus 90.02 0.00e+00 859.00
IUUC-Laf-053599 Loxodonta africana 97.33 0.00e+00 882.00
IUUC-Mcc-055225 Macaca mulatta 98.37 0.00e+00 938.00
IUUC-Meu-056341 Macropus eugenii 95.82 0.00e+00 909.00
IUUC-Mga-059525 Meleagris gallopavo 95.77 0.00e+00 870.00
IUUC-Mmr-060571 Microcebus murinus 98.17 0.00e+00 937.00
IUUC-Mdo-062229 Monodelphis domestica 96.88 0.00e+00 880.00
IUUC-Mpu-065742 Mustela putorius furo 97.35 0.00e+00 931.00
IUUC-Mlu-067442 Myotis lucifugus 95.05 0.00e+00 889.00
IUUC-Nle-069404 Nomascus leucogenys 98.12 0.00e+00 925.00
IUUC-Opr-070457 Ochotona princeps 97.29 0.00e+00 920.00
IUUC-Ont-072288 Oreochromis niloticus 70.68 0.00e+00 682.00
IUUC-Oan-073492 Ornithorhynchus anatinus 94.59 0.00e+00 855.00
IUUC-Ocu-074513 Oryctolagus cuniculus 97.75 0.00e+00 876.00
IUUC-Ola-086573 Oryzias latipes 70.68 0.00e+00 654.00
IUUC-Olu-087656 Ostreococcus lucimarinus 27.10 1.00e-06 47.40
IUUC-Oga-088674 Otolemur garnettii 96.88 0.00e+00 917.00
IUUC-Oar-090268 Ovis aries 91.31 0.00e+00 831.00
IUUC-Ptr-091375 Pan troglodytes 98.37 0.00e+00 938.00
IUUC-Pan-091683 Papio anubis 98.66 0.00e+00 892.00
IUUC-Psi-093199 Pelodiscus sinensis 96.21 0.00e+00 877.00
IUUC-Pma-094494 Petromyzon marinus 54.07 2.00e-113 402.00
IUUC-Pno-094936 Phaeosphaeria nodorum 25.11 9.00e-21 95.90
IUUC-Pfo-097004 Poecilia formosa 69.80 0.00e+00 677.00
IUUC-Pab-098590 Pongo abelii 98.42 0.00e+00 881.00
IUUC-Pca-100228 Procavia capensis 84.15 0.00e+00 751.00
IUUC-Pva-103166 Pteropus vampyrus 96.87 0.00e+00 911.00
IUUC-Ptt-103850 Puccinia triticina 23.02 9.00e-08 52.40
IUUC-Rno-104887 Rattus norvegicus 99.77 0.00e+00 898.00
IUUC-Sha-107379 Sarcophilus harrisii 96.44 0.00e+00 877.00
IUUC-Ssl-108575 Sclerotinia sclerotiorum 27.73 3.00e-16 80.90
IUUC-Sly-111591 Solanum lycopersicum 34.40 2.00e-30 127.00
IUUC-Stu-112488 Solanum tuberosum 33.83 7.00e-30 125.00
IUUC-Sar-113379 Sorex araneus 95.62 0.00e+00 908.00
IUUC-Ssc-115408 Sus scrofa 98.00 0.00e+00 890.00
IUUC-Tgu-117432 Taeniopygia guttata 95.62 0.00e+00 905.00
IUUC-Tru-117799 Takifugu rubripes 70.08 0.00e+00 677.00
IUUC-Tsy-119149 Tarsius syrichta 70.81 5.00e-54 204.00
IUUC-Tni-120688 Tetraodon nigroviridis 71.08 0.00e+00 674.00
IUUC-Tbe-127372 Tupaia belangeri 97.29 0.00e+00 915.00
IUUC-Ttr-128176 Tursiops truncatus 96.24 0.00e+00 909.00
IUUC-Vpa-130343 Vicugna pacos 98.77 4.00e-141 494.00
IUUC-Xtr-132187 Xenopus tropicalis 94.01 0.00e+00 865.00
IUUC-Xma-134176 Xiphophorus maculatus 69.80 0.00e+00 676.00
Created Date 25-Jun-2017

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