iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19141674

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.20e-10	41.7	6	47

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e f   d+++ + CgH+fh++Cl++w        ++ +CP Cr
   Q: 6    CVICAELFgqADEVFATVCGHMFHHNCLNQW------LDRSKTCPQCR 47
           ******9999666******************......**********8 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MLNLNCVICA ELFGQADEVF ATVCGHMFHH NCLNQWLDRS KTCPQCRNKC TTRNIFRVYF 60
NLANLDVSHI DVGSLQEQLD NAMLSMKMVE KERNKDEQQI RDLKETQKKC LKTIAGLEQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCCAAGTT AGTTAGCAAT TAGTTTGTCG TGGAAATATC TATCAGCTAA CAGTTATTGT 60
CTACAATCGA TTCTTGACAA ATACTGGTGT GGTGAATTCC GCTCATTGGA GCATCGTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0005634--C:nucleus
GO:0070182--F:DNA polymerase binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008219--P:cell death
GO:0045977--P:positive regulation of mitotic cell cycle, embryonic
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001411	Ailuropoda melanoleuca	28.36	5.00e-22	98.20
IUUC-Aca-004476	Anolis carolinensis	27.72	5.00e-21	94.70
IUUC-Bta-013084	Bos taurus	31.03	7.00e-23	100.00
IUUC-Bol-015543	Brassica oleracea	34.18	5.00e-11	61.60
IUUC-Bra-017106	Brassica rapa	34.18	5.00e-11	61.60
IUUC-Cel-018227	Caenorhabditis elegans	27.51	6.00e-13	67.80
IUUC-Cja-019856	Callithrix jacchus	27.62	3.00e-23	102.00
IUUC-Cfa-020075	Canis familiaris	28.20	2.00e-22	99.40
IUUC-Cpo-022481	Cavia porcellus	28.12	9.00e-23	100.00
IUUC-Csa-023793	Chlorocebus sabaeus	26.75	2.00e-23	102.00
IUUC-Cin-025749	Ciona intestinalis	39.06	4.00e-12	63.90
IUUC-Csv-026190	Ciona savignyi	25.53	8.00e-18	83.60
IUUC-Dre-027984	Danio rerio	29.28	2.00e-22	99.40
IUUC-Dno-029478	Dasypus novemcinctus	26.58	3.00e-22	98.60
IUUC-Dor-030526	Dipodomys ordii	40.23	5.00e-14	71.60
IUUC-Ete-033012	Echinops telfairi	28.86	1.00e-23	103.00
IUUC-Eca-034084	Equus caballus	27.92	2.00e-23	102.00
IUUC-Eeu-034579	Erinaceus europaeus	24.52	9.00e-11	60.50
IUUC-Fca-035772	Felis catus	28.36	4.00e-22	98.20
IUUC-Fal-037098	Ficedula albicollis	29.21	2.00e-22	99.40
IUUC-Gmo-038704	Gadus morhua	24.18	8.00e-18	84.00
IUUC-Gga-041109	Gallus gallus	24.41	3.00e-16	79.00
IUUC-Gac-042636	Gasterosteus aculeatus	25.65	2.00e-23	102.00
IUUC-Ggo-045184	Gorilla gorilla	26.75	2.00e-23	103.00
IUUC-Hsa-046651	Homo sapiens	26.75	1.00e-23	103.00
IUUC-Itr-048550	Ictidomys tridecemlineatus	26.10	7.00e-24	104.00
IUUC-Lch-049575	Latimeria chalumnae	27.20	2.00e-21	96.30
IUUC-Loc-051999	Lepisosteus oculatus	26.94	2.00e-23	102.00
IUUC-Laf-053347	Loxodonta africana	27.92	7.00e-24	104.00
IUUC-Mcc-054668	Macaca mulatta	35.19	1.00e-15	75.90
IUUC-Meu-056862	Macropus eugenii	25.76	2.00e-15	76.30
IUUC-Mmr-061219	Microcebus murinus	26.35	2.00e-24	105.00
IUUC-Mdo-062103	Monodelphis domestica	28.41	7.00e-22	97.40
IUUC-Mmu-064005	Mus musculus	24.14	2.00e-20	92.80
IUUC-Mpu-066570	Mustela putorius furo	28.36	5.00e-22	98.20
IUUC-Mlu-067806	Myotis lucifugus	28.68	5.00e-25	107.00
IUUC-Nle-069123	Nomascus leucogenys	26.43	5.00e-23	101.00
IUUC-Opr-071063	Ochotona princeps	25.00	2.00e-21	96.30
IUUC-Ont-071973	Oreochromis niloticus	27.01	2.00e-24	105.00
IUUC-Oan-072840	Ornithorhynchus anatinus	37.50	7.00e-12	60.50
IUUC-Ocu-074582	Oryctolagus cuniculus	25.93	7.00e-22	97.80
IUUC-Oba-075061	Oryza barthii	48.94	1.00e-09	56.20
IUUC-Ogl-077736	Oryza glaberrima	50.00	1.00e-09	56.20
IUUC-Ogu-078297	Oryza glumaepatula	51.06	2.00e-10	58.90
IUUC-Oin-080049	Oryza indica	50.00	1.00e-09	56.60
IUUC-Olo-080373	Oryza longistaminata	51.06	1.00e-10	58.20
IUUC-Ome-081676	Oryza meridionalis	50.00	2.00e-09	56.20
IUUC-Oni-082200	Oryza nivara	50.00	9.00e-10	56.60
IUUC-Oru-084737	Oryza rufipogon	50.00	9.00e-10	56.60
IUUC-Ola-086959	Oryzias latipes	26.37	1.00e-22	99.80
IUUC-Oga-088807	Otolemur garnettii	29.90	2.00e-20	93.20
IUUC-Oar-089273	Ovis aries	25.80	5.00e-16	78.20
IUUC-Ptr-090768	Pan troglodytes	27.07	7.00e-24	104.00
IUUC-Pan-091880	Papio anubis	26.67	2.00e-23	102.00
IUUC-Psi-093782	Pelodiscus sinensis	28.14	8.00e-24	103.00
IUUC-Ppa-095896	Physcomitrella patens	37.78	7.00e-12	65.10
IUUC-Pfo-096068	Poecilia formosa	26.34	2.00e-18	85.90
IUUC-Pab-098063	Pongo abelii	25.08	9.00e-18	84.00
IUUC-Pca-100327	Procavia capensis	28.25	3.00e-25	108.00
IUUC-Pva-102924	Pteropus vampyrus	28.68	3.00e-24	105.00
IUUC-Rno-105799	Rattus norvegicus	29.10	3.00e-21	95.90
IUUC-Sha-107643	Sarcophilus harrisii	25.41	4.00e-12	65.10
IUUC-Sly-111144	Solanum lycopersicum	32.17	1.00e-09	57.00
IUUC-Sar-113187	Sorex araneus	27.96	8.00e-21	94.00
IUUC-Ssc-115838	Sus scrofa	31.03	9.00e-23	99.80
IUUC-Tgu-116674	Taeniopygia guttata	28.04	1.00e-18	87.00
IUUC-Tru-117753	Takifugu rubripes	27.24	3.00e-25	108.00
IUUC-Tsy-119416	Tarsius syrichta	40.23	1.00e-13	70.10
IUUC-Tni-120767	Tetraodon nigroviridis	28.15	4.00e-22	98.60
IUUC-Ttr-128687	Tursiops truncatus	29.21	1.00e-23	103.00
IUUC-Xtr-131905	Xenopus tropicalis	26.52	3.00e-24	105.00
IUUC-Xma-133304	Xiphophorus maculatus	26.96	1.00e-20	93.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence