iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089371

Ensembl Protein ID

ENSOARP00000017230.1

UniProt Accession

W5Q3E2; W5Q3E2_SHEEP

Genbank Protein ID

ENSOARP00000017230

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01063337

Gene Name

HECTD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000016040.1	ENSOART00000017472.1	ENSOARP00000017230.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.70e-103	344.6	392	730

Active Site

Position(s)	Description	Evidence
698	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y++++ ++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 392  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSYCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDI 475
           589*************************************************9977765.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++ +dl +++pel++ l e++++ e ++ee  +  tf+v +e++g +k+++LkpgG++ipV
   Q: 476  RFPPCCYKKLLSPpivpsdqntpvgicSVTTDDLCQIMPELAHGLSELLSY-EGNVEED-FYSTFQVFQEEFGIIKSYNLKPGGDKIPV 562
           ************9666666666665555**********************9.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l++ t+y+g y +++ +i++Fw+v+ 
   Q: 563  TNQNRKEYVQLYIDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YAKTDLTIRYFWDVVL 650
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  + +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 651  GFPLDLQKKLLHFTTGSDRVPVGGMADLN---FKISKnETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 730
           *****************************...9999967777**************************************985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

GLDRGFKGQI SAFSSVISTV NQKKEATENR SSPTHLVFPN IKNVRDLPPI SLDVRQKQRI 60
STDPLSSEIK APVLPEPILP VQPKTMKDFL EDVEKAKSSG DWKTVYDFYL TTFDSFPELS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCCCATC GTGTCGGCGG GCGCCAGTGC CCCTGCGGTA GGTGCCGGGC GGGGGCCGCG 60
GGGCGCCCCG ACGGCCGGTC GCGAGGGGGG CGAGGGGCGC CCGGGGACCC GCTTCTCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	95.50	0.00e+00	1437.00
IUUC-Apl-003589	Anas platyrhynchos	85.91	0.00e+00	1277.00
IUUC-Aca-004350	Anolis carolinensis	81.64	0.00e+00	1207.00
IUUC-Ago-007908	Ashbya gossypii	34.60	6.00e-80	292.00
IUUC-Acl-008288	Aspergillus clavatus	35.20	5.00e-95	343.00
IUUC-Afl-008402	Aspergillus flavus	34.00	9.00e-89	321.00
IUUC-Afu-008762	Aspergillus fumigatus	34.32	6.00e-92	332.00
IUUC-Ani-009176	Aspergillus nidulans	36.01	2.00e-91	330.00
IUUC-Ang-009791	Aspergillus niger	36.03	2.00e-91	331.00
IUUC-Aor-009921	Aspergillus oryzae	33.83	4.00e-88	319.00
IUUC-Ate-010295	Aspergillus terreus	36.10	1.00e-98	354.00
IUUC-Ame-010660	Astyanax mexicanus	82.94	8.00e-154	535.00
IUUC-Bgr-011981	Blumeria graminis	34.96	1.00e-91	331.00
IUUC-Bta-012945	Bos taurus	99.45	0.00e+00	1463.00
IUUC-Bci-013697	Botrytis cinerea	36.45	1.00e-78	288.00
IUUC-Cja-019263	Callithrix jacchus	93.32	0.00e+00	1377.00
IUUC-Cfa-020486	Canis familiaris	96.90	0.00e+00	1291.00
IUUC-Cpo-021755	Cavia porcellus	93.42	0.00e+00	1392.00
IUUC-Csa-023814	Chlorocebus sabaeus	93.92	0.00e+00	1308.00
IUUC-Cho-024980	Choloepus hoffmanni	77.26	0.00e+00	1096.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	42.27	8.00e-96	345.00
IUUC-Dre-028551	Danio rerio	76.88	0.00e+00	1139.00
IUUC-Dno-029497	Dasypus novemcinctus	92.46	0.00e+00	1254.00
IUUC-Dor-030867	Dipodomys ordii	82.58	0.00e+00	1192.00
IUUC-Dse-031239	Dothistroma septosporum	32.21	2.00e-86	314.00
IUUC-Ete-032902	Echinops telfairi	79.32	0.00e+00	1148.00
IUUC-Eca-033678	Equus caballus	95.62	0.00e+00	1412.00
IUUC-Eeu-035262	Erinaceus europaeus	78.43	0.00e+00	1048.00
IUUC-Fca-035590	Felis catus	95.89	0.00e+00	1443.00
IUUC-Fal-037123	Ficedula albicollis	82.04	0.00e+00	1204.00
IUUC-Fox-037941	Fusarium oxysporum	40.68	5.00e-100	359.00
IUUC-Fso-038388	Fusarium solani	41.47	9.00e-103	368.00
IUUC-Gmo-039553	Gadus morhua	66.30	0.00e+00	846.00
IUUC-Ggr-040110	Gaeumannomyces graminis	40.48	7.00e-97	348.00
IUUC-Gga-040406	Gallus gallus	86.16	0.00e+00	1310.00
IUUC-Gac-042141	Gasterosteus aculeatus	75.80	0.00e+00	1098.00
IUUC-Ggo-045504	Gorilla gorilla	92.64	0.00e+00	1372.00
IUUC-Hsa-045786	Homo sapiens	93.42	0.00e+00	1378.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	89.97	0.00e+00	1225.00
IUUC-Kpa-049152	Komagataella pastoris	33.98	1.00e-74	274.00
IUUC-Lch-049824	Latimeria chalumnae	81.48	0.00e+00	1102.00
IUUC-Loc-052173	Lepisosteus oculatus	80.03	0.00e+00	1176.00
IUUC-Laf-054017	Loxodonta africana	95.05	0.00e+00	1326.00
IUUC-Mcc-055713	Macaca mulatta	93.60	0.00e+00	1366.00
IUUC-Meu-056212	Macropus eugenii	70.37	5.00e-118	418.00
IUUC-Mor-057045	Magnaporthe oryzae	36.40	1.00e-88	321.00
IUUC-Mla-059187	Melampsora laricipopulina	43.95	1.00e-86	313.00
IUUC-Mga-059884	Meleagris gallopavo	79.78	0.00e+00	1156.00
IUUC-Mmr-061344	Microcebus murinus	94.51	0.00e+00	1399.00
IUUC-Mdo-062653	Monodelphis domestica	88.84	0.00e+00	1305.00
IUUC-Mmu-063775	Mus musculus	91.11	0.00e+00	1283.00
IUUC-Mpu-066069	Mustela putorius furo	96.68	0.00e+00	1321.00
IUUC-Mlu-067925	Myotis lucifugus	95.21	0.00e+00	1388.00
IUUC-Nfi-068439	Neosartorya fischeri	34.32	5.00e-92	332.00
IUUC-Ncr-068903	Neurospora crassa	37.88	1.00e-91	332.00
IUUC-Nle-070046	Nomascus leucogenys	93.19	0.00e+00	1386.00
IUUC-Opr-071085	Ochotona princeps	79.53	4.00e-137	481.00
IUUC-Ont-072126	Oreochromis niloticus	73.16	0.00e+00	1135.00
IUUC-Oan-072933	Ornithorhynchus anatinus	88.72	0.00e+00	1166.00
IUUC-Ocu-073800	Oryctolagus cuniculus	95.77	0.00e+00	1285.00
IUUC-Ola-086988	Oryzias latipes	75.98	0.00e+00	1104.00
IUUC-Oga-088117	Otolemur garnettii	96.90	0.00e+00	1130.00
IUUC-Ptr-090551	Pan troglodytes	92.42	0.00e+00	1342.00
IUUC-Pan-092067	Papio anubis	94.11	0.00e+00	1371.00
IUUC-Psi-092963	Pelodiscus sinensis	87.26	0.00e+00	1258.00
IUUC-Pfo-096562	Poecilia formosa	74.71	0.00e+00	1102.00
IUUC-Pab-098680	Pongo abelii	93.70	0.00e+00	1381.00
IUUC-Pca-100986	Procavia capensis	76.33	0.00e+00	892.00
IUUC-Pva-102219	Pteropus vampyrus	79.86	0.00e+00	1064.00
IUUC-Pgr-103315	Puccinia graminis	36.28	2.00e-94	340.00
IUUC-Ptt-103736	Puccinia triticina	41.91	4.00e-94	339.00
IUUC-Rno-105270	Rattus norvegicus	91.78	0.00e+00	1291.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.65	2.00e-68	253.00
IUUC-Sha-106819	Sarcophilus harrisii	90.00	0.00e+00	1355.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.41	9.00e-84	305.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	33.88	7.00e-83	302.00
IUUC-Sar-113134	Sorex araneus	85.62	0.00e+00	1221.00
IUUC-Ssc-115441	Sus scrofa	96.85	0.00e+00	1399.00
IUUC-Tgu-117166	Taeniopygia guttata	84.38	0.00e+00	1230.00
IUUC-Tsy-118898	Tarsius syrichta	80.90	0.00e+00	1103.00
IUUC-Tre-122108	Trichoderma reesei	39.15	3.00e-89	323.00
IUUC-Tvi-122644	Trichoderma virens	39.72	7.00e-95	342.00
IUUC-Tme-127004	Tuber melanosporum	34.56	1.00e-100	362.00
IUUC-Tbe-127292	Tupaia belangeri	78.63	0.00e+00	1063.00
IUUC-Ttr-128352	Tursiops truncatus	92.74	0.00e+00	1347.00
IUUC-Vda-129969	Verticillium dahliae	40.44	9.00e-92	332.00
IUUC-Vpa-130218	Vicugna pacos	94.25	0.00e+00	1004.00
IUUC-Xtr-132594	Xenopus tropicalis	79.18	0.00e+00	1145.00
IUUC-Xma-134157	Xiphophorus maculatus	74.69	0.00e+00	1030.00
IUUC-Yli-134470	Yarrowia lipolytica	30.69	1.00e-75	278.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence