iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004372

UUCD1 version

UUC-AnC-00613

Ensembl Protein ID

ENSACAP00000006994.3

UniProt Accession

G1KG76; G1KG76_ANOCA

Protein Name

Uncharacterized protein

Gene Name

CISH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000007162.3	ENSACAT00000007145.3	ENSACAP00000006994.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.30e-13	50.5	218	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 10   eprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
             +SLqhLCRl I+r++  +++     LPLPk++kdYL+ +++
   Q: 218  GAPSLQHLCRLQINRSTEETEQ-----LPLPKRMKDYLKLYPF 255
           489**************99655.....************9986 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MLFPWSWRDM ILCVQGSHPL LAEEKIRRRS LGGLTVNVSE QVMQPLPVVP FQDEAAPPPS 60
VAPTLESKPL QARDPEEDLL CIAKTFSYLR ESGWYWGSIT ASEAKQQLQK TPEGTFLVRD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAACGGGTT GGCCGGCGAG CGCAGCCTCC GCACCGAGCC CCCGCCTCCA CGGTTCCTCC 60
TGATCGCCTT TAAACGCGCG CTCGGTGTCT CGATCCCTGT CGGTTTTCCT GGACAGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

acs:100552117

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	64.00	2.00e-78	285.00
IUUC-Ame-010787	Astyanax mexicanus	47.18	3.00e-52	197.00
IUUC-Bta-012826	Bos taurus	63.04	6.00e-85	306.00
IUUC-Cja-020004	Callithrix jacchus	61.66	5.00e-78	283.00
IUUC-Cfa-020150	Canis familiaris	62.80	1.00e-77	282.00
IUUC-Csa-023173	Chlorocebus sabaeus	61.51	1.00e-77	282.00
IUUC-Dre-028606	Danio rerio	46.55	4.00e-37	147.00
IUUC-Dno-028956	Dasypus novemcinctus	62.40	2.00e-80	291.00
IUUC-Dor-030148	Dipodomys ordii	57.59	4.00e-74	270.00
IUUC-Ete-032313	Echinops telfairi	60.70	1.00e-76	278.00
IUUC-Eca-033422	Equus caballus	63.08	5.00e-85	306.00
IUUC-Eeu-034806	Erinaceus europaeus	61.75	3.00e-77	281.00
IUUC-Fca-036374	Felis catus	62.31	1.00e-84	305.00
IUUC-Fal-036801	Ficedula albicollis	77.61	2.00e-107	381.00
IUUC-Gmo-038483	Gadus morhua	45.69	6.00e-39	153.00
IUUC-Gga-040891	Gallus gallus	76.83	2.00e-100	358.00
IUUC-Gac-042147	Gasterosteus aculeatus	41.63	1.00e-37	149.00
IUUC-Ggo-045511	Gorilla gorilla	61.51	2.00e-77	281.00
IUUC-Hsa-046678	Homo sapiens	63.60	2.00e-81	295.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	64.62	3.00e-87	314.00
IUUC-Lch-050555	Latimeria chalumnae	63.45	3.00e-80	290.00
IUUC-Laf-054141	Loxodonta africana	63.46	1.00e-86	312.00
IUUC-Mcc-055401	Macaca mulatta	61.51	2.00e-77	281.00
IUUC-Meu-056592	Macropus eugenii	68.00	4.00e-84	303.00
IUUC-Mga-059515	Meleagris gallopavo	76.86	7.00e-92	329.00
IUUC-Mmr-060848	Microcebus murinus	62.95	3.00e-79	287.00
IUUC-Mdo-062720	Monodelphis domestica	68.24	2.00e-92	331.00
IUUC-Mmu-063348	Mus musculus	62.41	2.00e-84	305.00
IUUC-Mpu-065834	Mustela putorius furo	63.08	4.00e-80	290.00
IUUC-Mlu-067687	Myotis lucifugus	65.12	8.00e-77	279.00
IUUC-Nle-069277	Nomascus leucogenys	61.30	7.00e-81	293.00
IUUC-Ont-071890	Oreochromis niloticus	50.55	9.00e-39	152.00
IUUC-Oan-073672	Ornithorhynchus anatinus	74.12	1.00e-97	348.00
IUUC-Ocu-073875	Oryctolagus cuniculus	64.54	6.00e-82	296.00
IUUC-Ola-087140	Oryzias latipes	51.23	5.00e-28	116.00
IUUC-Oga-087943	Otolemur garnettii	63.46	3.00e-83	301.00
IUUC-Oar-090194	Ovis aries	61.69	3.00e-79	287.00
IUUC-Ptr-090934	Pan troglodytes	61.11	3.00e-77	281.00
IUUC-Pan-092121	Papio anubis	61.69	6.00e-82	296.00
IUUC-Psi-093733	Pelodiscus sinensis	77.50	6.00e-100	356.00
IUUC-Pma-094671	Petromyzon marinus	46.39	4.00e-35	140.00
IUUC-Pfo-096313	Poecilia formosa	51.08	2.00e-45	175.00
IUUC-Pab-098439	Pongo abelii	61.69	9.00e-82	296.00
IUUC-Pca-101010	Procavia capensis	61.54	2.00e-82	298.00
IUUC-Pva-103112	Pteropus vampyrus	62.31	1.00e-82	299.00
IUUC-Rno-105917	Rattus norvegicus	63.46	3.00e-82	297.00
IUUC-Sha-106954	Sarcophilus harrisii	68.99	3.00e-90	324.00
IUUC-Sar-113001	Sorex araneus	63.35	1.00e-77	282.00
IUUC-Ssc-115922	Sus scrofa	71.53	7.00e-50	188.00
IUUC-Tgu-117338	Taeniopygia guttata	79.34	3.00e-101	360.00
IUUC-Tru-118511	Takifugu rubripes	47.31	6.00e-35	139.00
IUUC-Tsy-119434	Tarsius syrichta	63.35	3.00e-80	290.00
IUUC-Tni-119837	Tetraodon nigroviridis	47.28	7.00e-34	136.00
IUUC-Ttr-128340	Tursiops truncatus	52.55	6.00e-56	209.00
IUUC-Vpa-130443	Vicugna pacos	64.20	1.00e-85	308.00
IUUC-Xtr-131784	Xenopus tropicalis	60.62	5.00e-78	283.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence