iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010293.3	ENSCAFT00000045397.1	ENSCAFP00000039850.1
ENSCAFG00000010293.3	ENSCAFT00000016332.3	ENSCAFP00000015107.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.10e-14	54.4	224	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++++     +d+LPLP+++ dYL+++++q
   Q: 224  LVQPFVRRSSARSLQHLCRLVINRLVPD-----VDCLPLPRRMADYLRQYPFQ 271
           57999***********************.....8****************986 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

HLEHTSHHHH HHDDSAHPTP SRPCSLLAVE RIGQRALWAQ SLELPEPAMQ PLPAGAFLEE 60
VTEETPAEPE SEPKVLDPEE DLLCIAKTFS YLRESGWYWG SITASEARQH LQKMPEGTFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCCTCT GCGTGCAGGG GTAAGCGCGC TCGCCGCCCC NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	95.26	3.00e-124	437.00
IUUC-Aca-004372	Anolis carolinensis	60.40	3.00e-80	291.00
IUUC-Ame-010787	Astyanax mexicanus	47.92	3.00e-49	187.00
IUUC-Bta-012826	Bos taurus	89.16	9.00e-121	426.00
IUUC-Cja-020004	Callithrix jacchus	89.06	4.00e-112	397.00
IUUC-Csa-023173	Chlorocebus sabaeus	89.06	4.00e-112	397.00
IUUC-Dre-028606	Danio rerio	43.86	5.00e-32	130.00
IUUC-Dno-028956	Dasypus novemcinctus	89.29	2.00e-120	424.00
IUUC-Dor-030148	Dipodomys ordii	74.30	3.00e-95	341.00
IUUC-Ete-032313	Echinops telfairi	83.33	5.00e-104	370.00
IUUC-Eca-033422	Equus caballus	93.20	1.00e-125	442.00
IUUC-Eeu-034806	Erinaceus europaeus	91.76	1.00e-114	405.00
IUUC-Fca-036374	Felis catus	94.00	1.00e-122	432.00
IUUC-Fal-036801	Ficedula albicollis	64.03	3.00e-81	294.00
IUUC-Gmo-038483	Gadus morhua	39.90	4.00e-33	134.00
IUUC-Gga-040891	Gallus gallus	66.27	2.00e-78	285.00
IUUC-Gac-042147	Gasterosteus aculeatus	43.35	8.00e-34	137.00
IUUC-Ggo-045511	Gorilla gorilla	89.68	5.00e-113	400.00
IUUC-Hsa-046678	Homo sapiens	89.24	2.00e-111	394.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	91.97	1.00e-123	435.00
IUUC-Lch-050555	Latimeria chalumnae	62.94	1.00e-67	249.00
IUUC-Laf-054141	Loxodonta africana	87.65	9.00e-117	412.00
IUUC-Mcc-055401	Macaca mulatta	88.67	6.00e-111	393.00
IUUC-Meu-056592	Macropus eugenii	69.72	1.00e-88	319.00
IUUC-Mga-059515	Meleagris gallopavo	66.01	4.00e-78	284.00
IUUC-Mmr-060848	Microcebus murinus	94.00	3.00e-120	424.00
IUUC-Mdo-062720	Monodelphis domestica	69.20	2.00e-86	311.00
IUUC-Mmu-063348	Mus musculus	89.16	3.00e-121	427.00
IUUC-Mpu-065834	Mustela putorius furo	94.40	6.00e-121	426.00
IUUC-Mlu-067687	Myotis lucifugus	87.60	6.00e-96	343.00
IUUC-Nle-069277	Nomascus leucogenys	89.24	3.00e-109	387.00
IUUC-Ont-071890	Oreochromis niloticus	45.03	6.00e-35	140.00
IUUC-Oan-073672	Ornithorhynchus anatinus	65.08	4.00e-83	300.00
IUUC-Ocu-073875	Oryctolagus cuniculus	90.87	9.00e-121	426.00
IUUC-Ola-087140	Oryzias latipes	45.03	3.00e-24	104.00
IUUC-Oga-087943	Otolemur garnettii	90.40	1.00e-116	412.00
IUUC-Oar-090194	Ovis aries	88.93	5.00e-123	433.00
IUUC-Ptr-090934	Pan troglodytes	88.89	1.00e-110	392.00
IUUC-Pan-092121	Papio anubis	89.24	9.00e-110	389.00
IUUC-Psi-093733	Pelodiscus sinensis	61.18	3.00e-82	297.00
IUUC-Pfo-096313	Poecilia formosa	46.31	2.00e-42	164.00
IUUC-Pab-098439	Pongo abelii	89.24	8.00e-111	392.00
IUUC-Pca-101010	Procavia capensis	87.25	3.00e-114	404.00
IUUC-Pva-103112	Pteropus vampyrus	90.36	3.00e-116	410.00
IUUC-Rno-105917	Rattus norvegicus	89.56	5.00e-113	400.00
IUUC-Sha-106954	Sarcophilus harrisii	66.80	6.00e-88	317.00
IUUC-Smo-109292	Selaginella moellendorffii	31.15	1.90e-01	30.80
IUUC-Sar-113001	Sorex araneus	91.37	3.00e-119	421.00
IUUC-Ssc-115922	Sus scrofa	92.54	1.00e-61	228.00
IUUC-Tgu-117338	Taeniopygia guttata	64.82	2.00e-82	298.00
IUUC-Tru-118511	Takifugu rubripes	45.56	9.00e-33	132.00
IUUC-Tsy-119434	Tarsius syrichta	90.00	6.00e-115	406.00
IUUC-Tni-119837	Tetraodon nigroviridis	41.84	2.00e-29	122.00
IUUC-Ttr-128340	Tursiops truncatus	76.00	1.00e-74	272.00
IUUC-Vpa-130443	Vicugna pacos	91.60	1.00e-123	435.00
IUUC-Xtr-131784	Xenopus tropicalis	53.88	4.00e-67	247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence