iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049638

Ensembl Protein ID

ENSLACP00000019297.1

UniProt Accession

H3BBM6; H3BBM6_LATCH

Genbank Protein ID

ENSLACP00000019297

Protein Name

Presenilin

Genbank Nucleotide ID

AFYH01050133

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000016973.1	ENSLACT00000019431.1	ENSLACP00000019297.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.00e-07	32.0	286	318

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgslea 34
           +eta+e++++iFP+l+ys+ +v+L+ +++ +++
   Q: 286  VETAQERNEPIFPALIYSSAMVWLVGMAKHDTT 318
           89***********************99986666 PP

Organism

Latimeria chalumnae

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

LITFMNTSDS EEDHCNERTA LMSSGSPPML SYQDDQETSA SPNNQPKKTK QRRSGGSRSS 60
NVTDNGTPES RPDERGAIVE NEEEEELTLK YGAKHVIMLF VPVTLCMMVV VATIKSVSYY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCAAAATA CCTCGCTACG GCACTGCTGC CAACCATTTG TAAACGTGCA CAAAATCCCA 60
GTGCTTCACG GGACACCCAA AGCCCAGGAT TTTTAAAATG CATGCCTTAA AACTAGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0022008--P:neurogenesis
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	43.82	1.00e-09	58.50
IUUC-Aml-002356	Ailuropoda melanoleuca	62.45	4.00e-116	411.00
IUUC-Apl-003959	Anas platyrhynchos	68.76	6.00e-143	500.00
IUUC-Aca-005160	Anolis carolinensis	69.25	8.00e-147	513.00
IUUC-Aly-005455	Arabidopsis lyrata	29.77	4.00e-16	79.00
IUUC-Ath-006730	Arabidopsis thaliana	31.63	3.00e-17	82.80
IUUC-Ame-010686	Astyanax mexicanus	70.27	1.00e-125	442.00
IUUC-Bta-013097	Bos taurus	67.88	2.00e-140	492.00
IUUC-Cja-018824	Callithrix jacchus	68.03	7.00e-138	483.00
IUUC-Cfa-020253	Canis familiaris	67.66	6.00e-141	493.00
IUUC-Cpo-021401	Cavia porcellus	68.68	5.00e-140	490.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.56	3.00e-28	119.00
IUUC-Csa-023369	Chlorocebus sabaeus	69.11	2.00e-142	498.00
IUUC-Csv-025967	Ciona savignyi	58.62	8.00e-106	377.00
IUUC-Dre-028526	Danio rerio	64.66	2.00e-135	475.00
IUUC-Dor-031127	Dipodomys ordii	67.46	4.00e-138	484.00
IUUC-Ete-033081	Echinops telfairi	61.67	4.00e-60	225.00
IUUC-Eca-034387	Equus caballus	68.95	1.00e-136	479.00
IUUC-Eeu-034846	Erinaceus europaeus	60.06	5.00e-99	354.00
IUUC-Fca-035396	Felis catus	67.97	8.00e-146	509.00
IUUC-Fal-037457	Ficedula albicollis	69.16	3.00e-143	501.00
IUUC-Gmo-038550	Gadus morhua	83.84	3.00e-98	351.00
IUUC-Gga-040706	Gallus gallus	69.55	1.00e-142	499.00
IUUC-Gac-042511	Gasterosteus aculeatus	60.88	2.00e-117	416.00
IUUC-Gma-043822	Glycine max	31.91	4.00e-14	72.00
IUUC-Ggo-045338	Gorilla gorilla	69.11	2.00e-142	498.00
IUUC-Hsa-046455	Homo sapiens	69.11	2.00e-142	498.00
IUUC-Hvu-047141	Hordeum vulgare	43.82	5.00e-10	58.90
IUUC-Itr-048731	Ictidomys tridecemlineatus	68.09	3.00e-141	494.00
IUUC-Lpe-051132	Leersia perrieri	35.51	3.00e-14	72.80
IUUC-Loc-052427	Lepisosteus oculatus	67.74	7.00e-148	516.00
IUUC-Laf-053758	Loxodonta africana	67.31	3.00e-144	504.00
IUUC-Mcc-054755	Macaca mulatta	69.11	4.00e-142	498.00
IUUC-Mor-057000	Magnaporthe oryzae	33.33	1.70e+00	28.50
IUUC-Mtr-058392	Medicago truncatula	35.00	5.00e-13	68.90
IUUC-Mmr-060890	Microcebus murinus	68.03	6.00e-141	493.00
IUUC-Mdo-062197	Monodelphis domestica	69.49	1.00e-149	523.00
IUUC-Mmu-063823	Mus musculus	68.31	1.00e-140	492.00
IUUC-Mac-064858	Musa acuminata	34.68	5.00e-13	68.20
IUUC-Mpu-066181	Mustela putorius furo	67.88	2.00e-141	495.00
IUUC-Nle-069596	Nomascus leucogenys	66.34	1.00e-127	449.00
IUUC-Opr-070344	Ochotona princeps	68.09	1.00e-141	496.00
IUUC-Ont-071867	Oreochromis niloticus	67.03	8.00e-127	446.00
IUUC-Oan-073378	Ornithorhynchus anatinus	64.87	8.00e-129	453.00
IUUC-Ocu-074652	Oryctolagus cuniculus	68.75	2.00e-140	492.00
IUUC-Oba-075256	Oryza barthii	37.38	7.00e-12	64.70
IUUC-Ogl-077097	Oryza glaberrima	34.78	2.00e-13	70.10
IUUC-Ogu-078570	Oryza glumaepatula	34.78	2.00e-13	70.10
IUUC-Oin-079244	Oryza indica	35.51	2.00e-13	70.90
IUUC-Ome-081814	Oryza meridionalis	34.78	1.00e-13	70.90
IUUC-Oni-082057	Oryza nivara	35.51	1.00e-13	70.90
IUUC-Opu-084176	Oryza punctata	35.51	3.00e-13	69.30
IUUC-Oru-084618	Oryza rufipogon	35.51	1.00e-13	70.50
IUUC-Osa-085602	Oryza sativa	35.51	1.00e-13	70.50
IUUC-Ola-086707	Oryzias latipes	71.57	3.00e-104	371.00
IUUC-Olu-087811	Ostreococcus lucimarinus	35.48	1.00e-35	143.00
IUUC-Oga-088560	Otolemur garnettii	67.67	1.00e-135	476.00
IUUC-Oar-089200	Ovis aries	68.61	3.00e-140	491.00
IUUC-Ptr-090569	Pan troglodytes	69.11	1.00e-142	499.00
IUUC-Pan-091742	Papio anubis	69.11	2.00e-142	498.00
IUUC-Pma-094612	Petromyzon marinus	71.32	4.00e-115	407.00
IUUC-Ppa-095431	Physcomitrella patens	32.57	6.00e-25	108.00
IUUC-Pab-098531	Pongo abelii	69.11	2.00e-142	498.00
IUUC-Pop-099661	Populus trichocarpa	29.28	6.00e-25	108.00
IUUC-Pca-101120	Procavia capensis	65.66	2.00e-130	459.00
IUUC-Ppe-101495	Prunus persica	32.88	2.00e-20	93.60
IUUC-Pva-102934	Pteropus vampyrus	62.74	2.00e-132	465.00
IUUC-Rno-106052	Rattus norvegicus	68.52	2.00e-142	499.00
IUUC-Sha-106876	Sarcophilus harrisii	68.80	6.00e-144	503.00
IUUC-Smo-109325	Selaginella moellendorffii	33.58	2.00e-25	109.00
IUUC-Stu-112433	Solanum tuberosum	29.16	9.00e-23	101.00
IUUC-Ssc-115380	Sus scrofa	68.74	1.00e-141	495.00
IUUC-Tgu-117280	Taeniopygia guttata	69.38	1.00e-144	505.00
IUUC-Tca-121865	Theobroma cacao	34.44	1.00e-18	87.40
IUUC-Tur-126237	Triticum urartu	43.82	4.00e-10	58.90
IUUC-Tbe-127632	Tupaia belangeri	73.72	7.00e-124	437.00
IUUC-Ttr-129008	Tursiops truncatus	67.39	8.00e-138	483.00
IUUC-Vvi-131312	Vitis vinifera	36.67	1.00e-18	87.80
IUUC-Xtr-132756	Xenopus tropicalis	67.45	5.00e-152	530.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence