iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-047913

Ensembl Protein ID

ENSSTOP00000002415.2

UniProt Accession

I3M0X8; I3M0X8_ICTTR

Genbank Protein ID

ENSSTOP00000002415

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01001183

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000002681.2	ENSSTOT00000002699.2	ENSSTOP00000002415.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.80e-13	49.1	352	380
ULD/UDP/UBQ/UBQ_Other	1.80e-10	40.5	225	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W+C++CTf+N+P++++CemCs++R+c
   Q: 352  QPGWSCPSCTFINAPNRPGCEMCSTQRPC 380
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlk......vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk.dgstihl 69
           qvtv++++++ +   +      v+ ++t++ L+e++++++g+pp+ qr+++ G+ L  + ++La+yg++ dg+ ++l
   Q: 225  QVTVEDATSAaSSASSahislqVHTHCTISALQEQVFSEFGFPPAVQRWVI-GRWLcVPERSLASYGVQqDGDPAFL 300
           56666666666666666655569****************************.88888*********77615555555 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MAPPAGGATA ADPGSAAVLL AVHAAVRPLG AGSNAETQLR RLQLSADPER PGRFRLGGNP 60
LILDSPIPQV SLEWPLESIS YTIRGPSQHE LQPPPGGPGT LSLRFLNTQE AQQWAALLRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CGGCGGGCGG GGCCACGGCC GCAGACCCGG GCTCAGCCGC AGTGCTCCTG 60
GCTGTGCACG CCGCGGTGAG ACCGCTGGGC GCCGGGTCCA ACGCTGAGAC GCAGCTGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	75.00	8.00e-120	422.00
IUUC-Apl-004151	Anas platyrhynchos	57.45	7.00e-15	71.20
IUUC-Acl-008308	Aspergillus clavatus	44.00	2.50e-02	33.10
IUUC-Afl-008658	Aspergillus flavus	37.93	2.10e-02	33.10
IUUC-Afu-008913	Aspergillus fumigatus	44.00	2.80e-02	32.70
IUUC-Aor-009946	Aspergillus oryzae	37.93	2.10e-02	33.10
IUUC-Bta-012948	Bos taurus	74.41	1.00e-122	432.00
IUUC-Cja-019031	Callithrix jacchus	75.89	7.00e-121	426.00
IUUC-Cfa-020863	Canis familiaris	69.13	3.00e-102	364.00
IUUC-Cpo-022499	Cavia porcellus	74.79	1.00e-124	439.00
IUUC-Csa-023641	Chlorocebus sabaeus	75.34	5.00e-120	423.00
IUUC-Cne-026853	Cryptococcus neoformans	46.15	6.00e-03	35.40
IUUC-Dno-029459	Dasypus novemcinctus	53.90	3.00e-53	201.00
IUUC-Dor-030914	Dipodomys ordii	60.84	3.00e-79	288.00
IUUC-Ete-032940	Echinops telfairi	65.48	2.00e-88	318.00
IUUC-Eca-033537	Equus caballus	73.61	3.00e-118	417.00
IUUC-Eeu-035176	Erinaceus europaeus	60.00	8.00e-55	207.00
IUUC-Fca-035971	Felis catus	75.80	2.00e-114	405.00
IUUC-Gmo-039219	Gadus morhua	34.95	6.00e-43	167.00
IUUC-Ggo-044678	Gorilla gorilla	73.51	2.00e-124	438.00
IUUC-Hsa-046578	Homo sapiens	76.16	6.00e-127	446.00
IUUC-Mcc-055686	Macaca mulatta	70.41	2.00e-120	424.00
IUUC-Meu-055912	Macropus eugenii	50.00	7.00e-55	207.00
IUUC-Mvi-060474	Microbotryum violaceum	50.00	3.30e-02	32.70
IUUC-Mmr-060584	Microcebus murinus	73.70	4.00e-127	447.00
IUUC-Mdo-062191	Monodelphis domestica	53.98	1.00e-77	283.00
IUUC-Mmu-063740	Mus musculus	67.95	3.00e-104	371.00
IUUC-Mpu-066878	Mustela putorius furo	73.91	2.00e-100	358.00
IUUC-Mlu-067878	Myotis lucifugus	73.77	3.00e-119	421.00
IUUC-Nle-069748	Nomascus leucogenys	74.92	1.00e-116	412.00
IUUC-Ont-072270	Oreochromis niloticus	36.76	2.00e-45	176.00
IUUC-Obr-076087	Oryza brachyantha	54.17	5.00e-04	37.70
IUUC-Oga-088300	Otolemur garnettii	74.14	1.00e-132	465.00
IUUC-Oar-089549	Ovis aries	75.13	3.00e-127	447.00
IUUC-Ptr-090961	Pan troglodytes	75.74	5.00e-114	403.00
IUUC-Pan-092687	Papio anubis	76.71	1.00e-123	435.00
IUUC-Pab-097872	Pongo abelii	71.64	6.00e-115	407.00
IUUC-Pca-100363	Procavia capensis	69.76	4.00e-64	238.00
IUUC-Pva-102595	Pteropus vampyrus	71.80	2.00e-103	368.00
IUUC-Rno-105856	Rattus norvegicus	67.48	3.00e-103	368.00
IUUC-Sha-106838	Sarcophilus harrisii	51.94	1.00e-66	246.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	45.16	3.00e-03	36.20
IUUC-Sar-113611	Sorex araneus	62.11	7.00e-25	107.00
IUUC-Ssc-116263	Sus scrofa	72.88	2.00e-126	444.00
IUUC-Tru-118089	Takifugu rubripes	39.40	1.00e-49	190.00
IUUC-Tni-120004	Tetraodon nigroviridis	39.55	2.00e-43	169.00
IUUC-Tbe-127471	Tupaia belangeri	63.41	3.00e-94	338.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence