iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020281

Ensembl Protein ID

ENSCAFP00000007423.3

UniProt Accession

A0A0A0MPB6; A0A0A0MPB6_CANLF

Genbank Protein ID

ENSCAFP00000007423

Protein Name

Peroxisome proliferator-activated receptor gamma

Genbank Nucleotide ID

AAEX03012061

Gene Name

PPARG

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000004991.3	ENSCAFT00000008018.3	ENSCAFP00000007423.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.22	0.00e+00	1001.00	IUUC-Hsa-046916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Protein Sequence
(Fasta)

MDWSFARNRQ NISVNYRKSL FHAVMGETLG DSLIDPESDS FADTLSASTS QETTMVDTEM 60
PFWPTNFGIS SVDLSVMDDH SHSFDIKPFT TVDFSSISTP HYEDIPFSRA DPMVADYKYD 120

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Nucleotide Sequence
(Fasta)

CAAGTCTTGC CAAAGCAGTG AGCAACATCA TGACACAACA TTTGTCACAG CTGGCTCTCT 60
AACAGGACAG TACCAGCCAA TTCAGGCCTA GTCCTTTGTG GATTTATTCC CACCTCTCCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01291--PROXISOMPAGR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0090575--C:RNA polymerase II transcription factor complex
GO:0008144--F:drug binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048469--P:cell maturation
GO:0032869--P:cellular response to insulin stimulus
GO:0042593--P:glucose homeostasis
GO:0042953--P:lipoprotein transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0010742--P:macrophage derived foam cell differentiation
GO:0030224--P:monocyte differentiation
GO:0010887--P:negative regulation of cholesterol storage
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217--P:regulation of blood pressure
GO:0055098--P:response to low-density lipoprotein particle
GO:0032526--P:response to retinoic acid
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001214	Ailuropoda melanoleuca	96.04	0.00e+00	971.00
IUUC-Aca-005129	Anolis carolinensis	89.16	0.00e+00	880.00
IUUC-Ame-010818	Astyanax mexicanus	65.99	0.00e+00	645.00
IUUC-Bta-013226	Bos taurus	97.03	0.00e+00	989.00
IUUC-Cja-019236	Callithrix jacchus	98.22	0.00e+00	1000.00
IUUC-Cpo-021587	Cavia porcellus	96.65	0.00e+00	936.00
IUUC-Csa-023400	Chlorocebus sabaeus	99.16	0.00e+00	952.00
IUUC-Cho-024593	Choloepus hoffmanni	86.34	0.00e+00	856.00
IUUC-Dre-028176	Danio rerio	60.82	6.00e-154	536.00
IUUC-Dno-029063	Dasypus novemcinctus	94.06	0.00e+00	951.00
IUUC-Dme-031794	Drosophila melanogaster	34.70	1.00e-55	211.00
IUUC-Ete-032520	Echinops telfairi	94.65	0.00e+00	955.00
IUUC-Fca-035935	Felis catus	99.21	0.00e+00	1012.00
IUUC-Fal-037524	Ficedula albicollis	92.63	0.00e+00	889.00
IUUC-Gga-041223	Gallus gallus	93.26	0.00e+00	892.00
IUUC-Gac-042156	Gasterosteus aculeatus	62.33	0.00e+00	639.00
IUUC-Ggo-045265	Gorilla gorilla	98.22	0.00e+00	1002.00
IUUC-Hsa-046916	Homo sapiens	98.22	0.00e+00	1001.00
IUUC-Lch-049759	Latimeria chalumnae	81.11	0.00e+00	684.00
IUUC-Loc-051870	Lepisosteus oculatus	74.38	0.00e+00	749.00
IUUC-Laf-054483	Loxodonta africana	96.63	0.00e+00	983.00
IUUC-Meu-056587	Macropus eugenii	94.60	0.00e+00	920.00
IUUC-Mga-059530	Meleagris gallopavo	93.26	0.00e+00	892.00
IUUC-Mmr-060576	Microcebus murinus	96.63	0.00e+00	986.00
IUUC-Mdo-061854	Monodelphis domestica	98.53	0.00e+00	942.00
IUUC-Mmu-063724	Mus musculus	96.63	0.00e+00	988.00
IUUC-Mpu-066888	Mustela putorius furo	99.37	0.00e+00	987.00
IUUC-Mlu-067978	Myotis lucifugus	98.42	0.00e+00	1037.00
IUUC-Nle-070069	Nomascus leucogenys	98.61	0.00e+00	1003.00
IUUC-Opr-070630	Ochotona princeps	93.85	0.00e+00	792.00
IUUC-Ont-071399	Oreochromis niloticus	59.67	3.00e-180	624.00
IUUC-Ocu-074862	Oryctolagus cuniculus	98.32	0.00e+00	945.00
IUUC-Ola-087266	Oryzias latipes	56.42	1.00e-159	556.00
IUUC-Oga-089143	Otolemur garnettii	96.63	0.00e+00	989.00
IUUC-Oar-089725	Ovis aries	97.03	0.00e+00	988.00
IUUC-Ptr-091580	Pan troglodytes	98.42	0.00e+00	1002.00
IUUC-Psi-093041	Pelodiscus sinensis	91.18	0.00e+00	869.00
IUUC-Pfo-097438	Poecilia formosa	59.18	3.00e-178	617.00
IUUC-Pab-098333	Pongo abelii	98.74	0.00e+00	943.00
IUUC-Pca-100861	Procavia capensis	97.69	0.00e+00	939.00
IUUC-Pva-102186	Pteropus vampyrus	88.91	0.00e+00	884.00
IUUC-Rno-105583	Rattus norvegicus	96.63	0.00e+00	987.00
IUUC-Sha-107484	Sarcophilus harrisii	96.33	0.00e+00	944.00
IUUC-Sar-112996	Sorex araneus	85.54	0.00e+00	651.00
IUUC-Ssc-115945	Sus scrofa	98.22	0.00e+00	998.00
IUUC-Tsy-119098	Tarsius syrichta	88.71	0.00e+00	873.00
IUUC-Tni-120902	Tetraodon nigroviridis	61.30	7.00e-174	603.00
IUUC-Tbe-127225	Tupaia belangeri	76.44	0.00e+00	721.00
IUUC-Ttr-129292	Tursiops truncatus	98.61	0.00e+00	1004.00
IUUC-Vpa-130378	Vicugna pacos	92.51	0.00e+00	796.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence