iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074183

UUCD1 version

UUC-OrC-00516

Ensembl Protein ID

ENSOCUP00000011989.2

UniProt Accession

G1T6F4; G1T6F4_RABIT

Protein Name

Uncharacterized protein

Gene Name

UBE3B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000013932.3	ENSOCUT00000013946.3	ENSOCUP00000011989.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-113	377.8	705	1070

Active Site

Position(s)	Description	Evidence
1038	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           ++++k +++v+fv+     E+g+d++Gv++efl++++k++++p l+lf+++++d++ l+p+p+s++++ ++l+lFef+G++lgka++
   Q: 705  QHAMKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHE-NYLQLFEFVGKMLGKAVY 789
           7899********************************************99987665.59*******76.****************** PP
   S: 84   dgrlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           +g ++d+p++++f+++llg+       s+++l+++d+e+yk+l++ik++ + di +lgl+l++  +e+++g+  ++eL+pgG++ipV
   Q: 790  EGIVVDVPFASFFLSQLLGHhhsvfYSSVDELPSLDSEFYKNLTSIKRY-DGDIADLGLTLSY--DEDVMGQLVCHELIPGGKTIPV 873
           ********************777777999********************.6788887777766..6999****************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwe 251
           tneNk +Y++l++++r++++ik+q++a+ +Gf+++i +e++++F++ el+ li+G+ +eid+edlkk+t y gg++ ++++i+w+w+
   Q: 874  TNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIRPEWIRMFSAPELQRLISGDnAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD 960
           ********************************************************9****************************** PP
   S: 252  vl.eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeY 313
           +l ++f+ +er++fL+FvT++sr Pl Gfa+lk                        + +f+irk +   rlP+s+TCfn+LkLP+Y
   Q: 961  ILaSDFTPDERAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1047
           **99*************************************************************8888****************** PP
   S: 314  sskeilkekLlyAieetkgFels 336
           s+k +l+ekL+yAi++++gFels
   Q: 1048 SKKGVLREKLRYAISMNTGFELS 1070
           ********************985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MFTVSQTSRA WFIDRARQAR EERLVQKERE RAVVAIQAHV RSFLCRRRLQ RDIRKEIDEF 60
FKADDAGSSR RSALCIFKIA RKLLFLFRIK EDDERFQKLC RSILSSMEAE SEAKVWYVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAACAGAGC AAGCTCTCTG GAGTGTGAAG CTGTCCTCAG CCGTGAGGCC TGAGCAGCAT 60
CACTGATGAT TACCTGACGT CTCTGCAGCA CAAGCAGGTC CCCAGGTGAG CACTCCAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS
IPR027401--Myosin-like_IQ_dom

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ocu:100338868

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	39.32	1.00e-105	378.00
IUUC-Aml-002107	Ailuropoda melanoleuca	95.05	0.00e+00	2047.00
IUUC-Atr-003017	Amborella trichopoda	38.30	3.00e-110	393.00
IUUC-Apl-003328	Anas platyrhynchos	87.00	0.00e+00	1828.00
IUUC-Aly-005794	Arabidopsis lyrata	38.93	1.00e-109	391.00
IUUC-Ath-007269	Arabidopsis thaliana	39.29	3.00e-112	400.00
IUUC-Bta-013547	Bos taurus	94.77	0.00e+00	2069.00
IUUC-Bdi-014502	Brachypodium distachyon	38.97	4.00e-110	392.00
IUUC-Bol-015093	Brassica oleracea	39.64	2.00e-112	400.00
IUUC-Bra-016722	Brassica rapa	40.00	3.00e-114	406.00
IUUC-Cel-018447	Caenorhabditis elegans	37.76	0.00e+00	681.00
IUUC-Cja-019855	Callithrix jacchus	94.95	0.00e+00	2048.00
IUUC-Cfa-020066	Canis familiaris	94.81	0.00e+00	2025.00
IUUC-Cpo-021504	Cavia porcellus	93.74	0.00e+00	2061.00
IUUC-Csa-023579	Chlorocebus sabaeus	95.42	0.00e+00	2055.00
IUUC-Cho-024430	Choloepus hoffmanni	84.33	0.00e+00	1512.00
IUUC-Cin-025750	Ciona intestinalis	47.25	0.00e+00	968.00
IUUC-Csv-026016	Ciona savignyi	48.14	0.00e+00	1018.00
IUUC-Dre-028271	Danio rerio	80.09	0.00e+00	1744.00
IUUC-Dno-029054	Dasypus novemcinctus	95.23	0.00e+00	2055.00
IUUC-Dor-030938	Dipodomys ordii	92.66	0.00e+00	1174.00
IUUC-Dme-031602	Drosophila melanogaster	47.47	0.00e+00	956.00
IUUC-Ete-033041	Echinops telfairi	74.63	0.00e+00	1331.00
IUUC-Eca-034411	Equus caballus	95.14	0.00e+00	2028.00
IUUC-Eeu-035201	Erinaceus europaeus	84.27	0.00e+00	801.00
IUUC-Fca-036594	Felis catus	94.11	0.00e+00	2003.00
IUUC-Fal-037317	Ficedula albicollis	83.23	0.00e+00	1835.00
IUUC-Gmo-039412	Gadus morhua	76.83	0.00e+00	1715.00
IUUC-Gga-040149	Gallus gallus	86.73	0.00e+00	1859.00
IUUC-Gac-042088	Gasterosteus aculeatus	79.10	0.00e+00	1796.00
IUUC-Gma-042728	Glycine max	41.21	5.00e-114	405.00
IUUC-Ggo-045279	Gorilla gorilla	95.23	0.00e+00	2051.00
IUUC-Hsa-045660	Homo sapiens	94.95	0.00e+00	2046.00
IUUC-Hvu-047102	Hordeum vulgare	39.08	4.00e-105	376.00
IUUC-Itr-048021	Ictidomys tridecemlineatus	91.75	0.00e+00	1040.00
IUUC-Lch-050664	Latimeria chalumnae	81.51	0.00e+00	1817.00
IUUC-Lpe-050755	Leersia perrieri	37.01	2.00e-98	353.00
IUUC-Loc-052791	Lepisosteus oculatus	82.03	0.00e+00	1767.00
IUUC-Laf-053902	Loxodonta africana	94.39	0.00e+00	2046.00
IUUC-Mcc-054730	Macaca mulatta	95.33	0.00e+00	2054.00
IUUC-Meu-056527	Macropus eugenii	78.92	0.00e+00	1654.00
IUUC-Mtr-057671	Medicago truncatula	40.32	3.00e-114	406.00
IUUC-Mga-059260	Meleagris gallopavo	86.38	0.00e+00	1857.00
IUUC-Mmr-060804	Microcebus murinus	94.21	0.00e+00	2003.00
IUUC-Mdo-062575	Monodelphis domestica	82.91	0.00e+00	1767.00
IUUC-Mmu-063636	Mus musculus	92.15	0.00e+00	1949.00
IUUC-Mac-064989	Musa acuminata	39.12	2.00e-107	383.00
IUUC-Mpu-066677	Mustela putorius furo	94.94	0.00e+00	1919.00
IUUC-Mlu-067952	Myotis lucifugus	94.77	0.00e+00	1972.00
IUUC-Nle-069153	Nomascus leucogenys	94.86	0.00e+00	2048.00
IUUC-Opr-070554	Ochotona princeps	95.30	0.00e+00	1873.00
IUUC-Ont-071372	Oreochromis niloticus	80.19	0.00e+00	1776.00
IUUC-Oan-073327	Ornithorhynchus anatinus	68.75	0.00e+00	717.00
IUUC-Oba-075213	Oryza barthii	38.34	2.00e-106	380.00
IUUC-Obr-076320	Oryza brachyantha	38.51	2.00e-109	390.00
IUUC-Ogl-077093	Oryza glaberrima	38.51	3.00e-109	390.00
IUUC-Ogu-078947	Oryza glumaepatula	36.69	6.00e-110	392.00
IUUC-Oin-080058	Oryza indica	38.51	5.00e-109	389.00
IUUC-Olo-080742	Oryza longistaminata	38.34	8.00e-108	385.00
IUUC-Ome-081741	Oryza meridionalis	37.57	2.00e-101	364.00
IUUC-Oni-082385	Oryza nivara	36.69	5.00e-110	392.00
IUUC-Opu-083529	Oryza punctata	38.51	7.00e-109	389.00
IUUC-Oru-085128	Oryza rufipogon	36.96	5.00e-96	345.00
IUUC-Osa-085557	Oryza sativa	38.51	1.00e-108	387.00
IUUC-Ola-087337	Oryzias latipes	79.35	0.00e+00	1716.00
IUUC-Oga-088342	Otolemur garnettii	94.49	0.00e+00	1961.00
IUUC-Oar-090234	Ovis aries	94.81	0.00e+00	2046.00
IUUC-Ptr-091661	Pan troglodytes	95.23	0.00e+00	2050.00
IUUC-Pan-092728	Papio anubis	94.86	0.00e+00	2048.00
IUUC-Psi-093251	Pelodiscus sinensis	86.59	0.00e+00	1723.00
IUUC-Pma-094195	Petromyzon marinus	69.55	0.00e+00	1450.00
IUUC-Ppa-095544	Physcomitrella patens	38.03	1.00e-110	394.00
IUUC-Pfo-097472	Poecilia formosa	79.63	0.00e+00	1778.00
IUUC-Pab-098570	Pongo abelii	95.05	0.00e+00	2047.00
IUUC-Pca-100110	Procavia capensis	82.80	0.00e+00	1711.00
IUUC-Ppe-101281	Prunus persica	39.18	2.00e-108	387.00
IUUC-Pva-102887	Pteropus vampyrus	89.73	0.00e+00	1900.00
IUUC-Rno-106028	Rattus norvegicus	88.33	0.00e+00	1843.00
IUUC-Sha-107331	Sarcophilus harrisii	84.42	0.00e+00	1801.00
IUUC-Smo-109488	Selaginella moellendorffii	37.14	5.00e-107	382.00
IUUC-Sit-109811	Setaria italica	34.85	4.00e-109	389.00
IUUC-Sly-111013	Solanum lycopersicum	39.59	3.00e-104	373.00
IUUC-Sar-113287	Sorex araneus	83.68	0.00e+00	703.00
IUUC-Sbi-114433	Sorghum bicolor	38.51	2.00e-109	390.00
IUUC-Ssc-116103	Sus scrofa	95.23	0.00e+00	2027.00
IUUC-Tgu-117275	Taeniopygia guttata	86.45	0.00e+00	1848.00
IUUC-Tru-118681	Takifugu rubripes	78.60	0.00e+00	1788.00
IUUC-Tsy-118985	Tarsius syrichta	89.52	0.00e+00	1024.00
IUUC-Tni-120850	Tetraodon nigroviridis	90.98	0.00e+00	773.00
IUUC-Tca-121770	Theobroma cacao	39.18	9.00e-112	398.00
IUUC-Tae-125466	Triticum aestivum	36.66	7.00e-108	385.00
IUUC-Tur-126086	Triticum urartu	39.25	5.00e-105	376.00
IUUC-Tbe-127461	Tupaia belangeri	90.37	0.00e+00	1863.00
IUUC-Ttr-129269	Tursiops truncatus	94.58	0.00e+00	2009.00
IUUC-Vpa-130523	Vicugna pacos	76.68	2.00e-127	450.00
IUUC-Vvi-131524	Vitis vinifera	39.22	1.00e-110	394.00
IUUC-Xtr-132146	Xenopus tropicalis	82.74	0.00e+00	1828.00
IUUC-Xma-133526	Xiphophorus maculatus	79.44	0.00e+00	1773.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence