iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000047219.2	ENSRNOT00000074000.2	ENSRNOP00000065953.2
ENSRNOG00000047219.2	ENSRNOT00000080049.1	ENSRNOP00000071414.1

Annotation

mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-91	307.3	706	1068

Active Site

Position(s)	Description	Evidence
1036	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
           +++k  ++v+fv      E+g+d++Gv++efl++++k++++p l+lf+++++d++ l+p+p+s++++ ++l+lFef+G++lgka+++
   Q: 706  HAMKGAIRVKFVSdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHE-NYLQLFEFVGKMLGKAVYE 790
           789999*****9999999*****************************99987665.59*******76.******************* PP
   S: 85   grlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVt 166
           g ++d+p++++f++++lg+       s+++l+++d+e+yk+l++ik++ + d+ +lgl+l++  +e+++g+  ++eL+pgG++ipVt
   Q: 791  GIVVDVPFASFFLSQMLGHhhsvfYSSVDELPSLDSEFYKNLTSIKRY-DGDVADLGLTLSY--DEDVMGQLVCHELVPGGKTIPVT 874
           *******************777777999********************.6788887766666..6999******************* PP
   S: 167  neNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketky.kggytedspaiqwFwe 251
            eNk +Y++l++++r+++ ik+q++a+ +Gf+++ p+ +  ++ +++++    G+ +  d+edlkk+t     g++++s++i w+w 
   Q: 875  DENKISYIHLMAHFRMHS-IKNQTAALISGFRSIKPEWIRCSLPASNVSS--PGQcPRSDLEDLKKHTDVpYTGLSRESRVIVWLWG 958
           *****************9.**************98877667788877765..67779***********444688************* PP
   S: 252  vl.eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeY 313
           +l ++f + e    LqFvT++sr Pl Gfa+lk                        + +f+irk +   rlP+s+TCfn+LkLP+Y
   Q: 959  ILaSDFHAGETELVLQFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
           **99*************************************************************8888****************** PP
   S: 314  sskeilkekLlyAieetkgFels 336
           s+k++l+ekL+yAi++++gFels
   Q: 1046 SKKSVLREKLRYAISMNTGFELS 1068
           ********************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MFTVSQTSRA WFLDKARQAR EERLEQKERE RSAVLIQALV RSFLCRRRLH KDVRREIDEF 60
FTADESGSSK RSALCIFKIA RKLLFICKTT EDNERMEKLC RSILSSMDAE NEPKVWYVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTTTTT TTAAACCACC ACAGTATCTT ACATTCAGCA ACATTACAAT GCCATGCCTG 60
CAAAAAAAAA AAAAAAAGTA CTAATTCTGA ATCTTTCTTA GGCCAGAAAG ACCAACTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	38.31	1.00e-90	328.00
IUUC-Aml-002107	Ailuropoda melanoleuca	88.89	0.00e+00	1901.00
IUUC-Atr-003017	Amborella trichopoda	37.52	7.00e-95	342.00
IUUC-Apl-003328	Anas platyrhynchos	83.08	0.00e+00	1716.00
IUUC-Aly-005794	Arabidopsis lyrata	37.06	4.00e-91	330.00
IUUC-Ath-007269	Arabidopsis thaliana	37.59	1.00e-93	338.00
IUUC-Ago-007748	Ashbya gossypii	35.06	2.00e-49	190.00
IUUC-Acl-008158	Aspergillus clavatus	30.20	3.00e-46	181.00
IUUC-Afl-008398	Aspergillus flavus	30.49	9.00e-50	192.00
IUUC-Afu-008937	Aspergillus fumigatus	29.94	8.00e-48	186.00
IUUC-Ani-009252	Aspergillus nidulans	30.14	2.00e-52	201.00
IUUC-Ang-009773	Aspergillus niger	28.41	3.00e-49	191.00
IUUC-Aor-009940	Aspergillus oryzae	30.49	9.00e-50	192.00
IUUC-Ate-010395	Aspergillus terreus	30.30	2.00e-48	188.00
IUUC-Bgr-012269	Blumeria graminis	30.27	3.00e-48	185.00
IUUC-Bta-013547	Bos taurus	88.98	0.00e+00	1924.00
IUUC-Bci-013743	Botrytis cinerea	31.10	2.00e-53	205.00
IUUC-Bdi-014502	Brachypodium distachyon	37.96	8.00e-95	342.00
IUUC-Bol-015093	Brassica oleracea	37.77	2.00e-94	340.00
IUUC-Bra-016722	Brassica rapa	37.77	5.00e-95	343.00
IUUC-Cel-018447	Caenorhabditis elegans	36.31	4.00e-177	615.00
IUUC-Cja-019855	Callithrix jacchus	88.89	0.00e+00	1905.00
IUUC-Cfa-020066	Canis familiaris	88.49	0.00e+00	1877.00
IUUC-Cpo-021504	Cavia porcellus	87.96	0.00e+00	1906.00
IUUC-Cre-022673	Chlamydomonas reinhardtii	35.29	3.00e-63	237.00
IUUC-Csa-023579	Chlorocebus sabaeus	89.45	0.00e+00	1915.00
IUUC-Cho-024430	Choloepus hoffmanni	79.32	0.00e+00	1412.00
IUUC-Cin-025750	Ciona intestinalis	44.45	0.00e+00	874.00
IUUC-Csv-026016	Ciona savignyi	45.72	0.00e+00	934.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	32.92	3.00e-57	217.00
IUUC-Cne-026841	Cryptococcus neoformans	36.19	6.00e-62	233.00
IUUC-Cme-027265	Cyanidioschyzon merolae	38.37	1.00e-74	275.00
IUUC-Dre-028271	Danio rerio	77.22	0.00e+00	1638.00
IUUC-Dno-029054	Dasypus novemcinctus	89.45	0.00e+00	1913.00
IUUC-Dor-030938	Dipodomys ordii	86.58	0.00e+00	1066.00
IUUC-Dse-031416	Dothistroma septosporum	31.58	1.00e-49	192.00
IUUC-Dme-031602	Drosophila melanogaster	46.00	0.00e+00	885.00
IUUC-Ete-033041	Echinops telfairi	71.86	0.00e+00	1261.00
IUUC-Eca-034411	Equus caballus	89.73	0.00e+00	1892.00
IUUC-Eeu-035201	Erinaceus europaeus	76.56	0.00e+00	700.00
IUUC-Fca-036594	Felis catus	88.33	0.00e+00	1863.00
IUUC-Fal-037317	Ficedula albicollis	79.93	0.00e+00	1728.00
IUUC-Fox-037788	Fusarium oxysporum	29.65	1.00e-59	224.00
IUUC-Fso-038088	Fusarium solani	28.87	8.00e-58	219.00
IUUC-Gmo-039412	Gadus morhua	74.51	0.00e+00	1617.00
IUUC-Ggr-039941	Gaeumannomyces graminis	31.21	1.00e-55	212.00
IUUC-Gga-040149	Gallus gallus	83.38	0.00e+00	1752.00
IUUC-Gac-042088	Gasterosteus aculeatus	76.23	0.00e+00	1696.00
IUUC-Gma-042728	Glycine max	39.72	4.00e-94	340.00
IUUC-Ggo-045279	Gorilla gorilla	88.98	0.00e+00	1910.00
IUUC-Hsa-045660	Homo sapiens	88.70	0.00e+00	1903.00
IUUC-Hvu-047102	Hordeum vulgare	38.31	3.00e-91	330.00
IUUC-Itr-048021	Ictidomys tridecemlineatus	89.86	0.00e+00	1008.00
IUUC-Kpa-049307	Komagataella pastoris	29.78	1.00e-50	194.00
IUUC-Lch-050664	Latimeria chalumnae	78.64	0.00e+00	1712.00
IUUC-Lpe-050755	Leersia perrieri	35.74	1.00e-83	305.00
IUUC-Loc-052791	Lepisosteus oculatus	78.88	0.00e+00	1667.00
IUUC-Lma-053096	Leptosphaeria maculans	32.58	5.00e-52	200.00
IUUC-Laf-053902	Loxodonta africana	89.26	0.00e+00	1915.00
IUUC-Mcc-054730	Macaca mulatta	89.36	0.00e+00	1915.00
IUUC-Meu-056527	Macropus eugenii	75.58	0.00e+00	1550.00
IUUC-Mor-057021	Magnaporthe oryzae	33.54	2.00e-46	181.00
IUUC-Mpo-057570	Magnaporthe poae	31.39	4.00e-53	203.00
IUUC-Mtr-057671	Medicago truncatula	38.39	9.00e-95	342.00
IUUC-Mla-059124	Melampsora laricipopulina	37.12	2.00e-67	249.00
IUUC-Mga-059260	Meleagris gallopavo	82.95	0.00e+00	1747.00
IUUC-Mvi-060445	Microbotryum violaceum	33.17	1.00e-70	262.00
IUUC-Mmr-060804	Microcebus murinus	88.42	0.00e+00	1850.00
IUUC-Mdo-062575	Monodelphis domestica	79.38	0.00e+00	1659.00
IUUC-Mmu-063636	Mus musculus	92.34	0.00e+00	1907.00
IUUC-Mac-064989	Musa acuminata	37.96	1.00e-92	335.00
IUUC-Mpu-066677	Mustela putorius furo	88.29	0.00e+00	1771.00
IUUC-Mlu-067952	Myotis lucifugus	88.42	0.00e+00	1829.00
IUUC-Nfi-068280	Neosartorya fischeri	30.14	3.00e-48	187.00
IUUC-Ncr-068869	Neurospora crassa	29.83	1.00e-53	205.00
IUUC-Nle-069153	Nomascus leucogenys	88.70	0.00e+00	1902.00
IUUC-Opr-070554	Ochotona princeps	88.16	0.00e+00	1725.00
IUUC-Ont-071372	Oreochromis niloticus	77.89	0.00e+00	1686.00
IUUC-Oan-073327	Ornithorhynchus anatinus	69.89	0.00e+00	723.00
IUUC-Ocu-074183	Oryctolagus cuniculus	88.33	0.00e+00	1880.00
IUUC-Oba-075213	Oryza barthii	37.52	3.00e-91	330.00
IUUC-Obr-076320	Oryza brachyantha	38.00	3.00e-94	340.00
IUUC-Ogl-077093	Oryza glaberrima	37.69	5.00e-94	339.00
IUUC-Ogu-078947	Oryza glumaepatula	34.38	1.00e-91	331.00
IUUC-Oin-080058	Oryza indica	37.69	2.00e-93	337.00
IUUC-Olo-080742	Oryza longistaminata	37.52	1.00e-92	335.00
IUUC-Ome-081741	Oryza meridionalis	36.95	1.00e-85	311.00
IUUC-Oni-082385	Oryza nivara	34.38	9.00e-92	332.00
IUUC-Opu-083529	Oryza punctata	38.00	6.00e-94	338.00
IUUC-Oru-085128	Oryza rufipogon	35.28	5.00e-80	292.00
IUUC-Osa-085557	Oryza sativa	37.94	4.00e-93	335.00
IUUC-Ola-087337	Oryzias latipes	77.05	0.00e+00	1617.00
IUUC-Olu-087699	Ostreococcus lucimarinus	38.01	6.00e-64	238.00
IUUC-Oga-088342	Otolemur garnettii	88.43	0.00e+00	1807.00
IUUC-Oar-090234	Ovis aries	88.21	0.00e+00	1887.00
IUUC-Ptr-091661	Pan troglodytes	89.08	0.00e+00	1911.00
IUUC-Pan-092728	Papio anubis	89.18	0.00e+00	1910.00
IUUC-Psi-093251	Pelodiscus sinensis	81.85	0.00e+00	1603.00
IUUC-Pma-094195	Petromyzon marinus	67.53	0.00e+00	1357.00
IUUC-Ppa-095544	Physcomitrella patens	36.59	7.00e-94	339.00
IUUC-Pfo-097472	Poecilia formosa	77.31	0.00e+00	1686.00
IUUC-Pab-098570	Pongo abelii	88.70	0.00e+00	1904.00
IUUC-Pop-098928	Populus trichocarpa	32.13	3.00e-82	300.00
IUUC-Pca-100110	Procavia capensis	77.87	0.00e+00	1593.00
IUUC-Ppe-101281	Prunus persica	37.32	5.00e-90	326.00
IUUC-Pva-102887	Pteropus vampyrus	84.42	0.00e+00	1768.00
IUUC-Ptt-103967	Puccinia triticina	35.43	5.00e-60	226.00
IUUC-Pte-104105	Pyrenophora teres	30.35	2.00e-55	211.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	31.89	1.00e-52	202.00
IUUC-Sce-106446	Saccharomyces cerevisiae	32.73	8.00e-45	175.00
IUUC-Sha-107331	Sarcophilus harrisii	80.80	0.00e+00	1682.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	36.49	9.00e-67	248.00
IUUC-Spo-108097	Schizosaccharomyces pombe	31.80	4.00e-67	249.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	28.00	9.00e-53	202.00
IUUC-Smo-109488	Selaginella moellendorffii	36.48	2.00e-91	330.00
IUUC-Sit-109811	Setaria italica	38.07	3.00e-94	340.00
IUUC-Sly-111013	Solanum lycopersicum	37.75	1.00e-85	311.00
IUUC-Sar-113287	Sorex araneus	80.19	0.00e+00	682.00
IUUC-Sbi-114433	Sorghum bicolor	38.07	4.00e-95	343.00
IUUC-Sre-115038	Sporisorium reilianum	36.01	9.00e-67	249.00
IUUC-Ssc-116103	Sus scrofa	89.17	0.00e+00	1883.00
IUUC-Tgu-117275	Taeniopygia guttata	82.63	0.00e+00	1734.00
IUUC-Tru-118681	Takifugu rubripes	76.56	0.00e+00	1697.00
IUUC-Tsy-118985	Tarsius syrichta	86.60	0.00e+00	994.00
IUUC-Tni-120850	Tetraodon nigroviridis	83.50	0.00e+00	684.00
IUUC-Tca-121770	Theobroma cacao	37.79	4.00e-95	343.00
IUUC-Tre-121892	Trichoderma reesei	34.04	2.00e-60	228.00
IUUC-Tvi-122354	Trichoderma virens	34.16	5.00e-63	236.00
IUUC-Tae-125466	Triticum aestivum	33.64	1.00e-87	318.00
IUUC-Tur-126086	Triticum urartu	38.31	3.00e-90	327.00
IUUC-Tme-127102	Tuber melanosporum	29.56	1.00e-64	242.00
IUUC-Tbe-127461	Tupaia belangeri	86.18	0.00e+00	1767.00
IUUC-Ttr-129269	Tursiops truncatus	88.33	0.00e+00	1858.00
IUUC-Uma-129343	Ustilago maydis	36.47	1.00e-68	255.00
IUUC-Vda-129748	Verticillium dahliae	30.08	5.00e-46	179.00
IUUC-Vpa-130523	Vicugna pacos	77.81	1.00e-117	417.00
IUUC-Vvi-131524	Vitis vinifera	37.61	4.00e-92	333.00
IUUC-Xtr-132146	Xenopus tropicalis	79.22	0.00e+00	1702.00
IUUC-Xma-133526	Xiphophorus maculatus	77.03	0.00e+00	1678.00
IUUC-Yli-134496	Yarrowia lipolytica	32.61	9.00e-57	215.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence