iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051981

Ensembl Protein ID

ENSLOCP00000019384.1

UniProt Accession

W5NFH5; W5NFH5_LEPOC

Genbank Protein ID

ENSLOCP00000019384

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01016203

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000015748.1	ENSLOCT00000019416.1	ENSLOCP00000019384.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.90e-100	334.5	300	700

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.......kkkeklneenp........................................ 42
           tGl+NlgNtCYmNS+LQ+Ls+++ +re++l+                ++                                        
   Q: 300  TGLRNLGNTCYMNSILQVLSHLHIFRECFLQldlnqdlD------FLASaangnsrpalcklvmrngkggespsptskrsllaglsgga 382
           7******************************75544331......33335566677899999999************************ PP
   S: 43   ..............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkee 117
                         ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         e
   Q: 383  srtrnmeliqpkepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWHLIPAFRGYAQQDAQEFLCELLDKVQQEL---------E 462
           ***9999999999999999************************************************************.........5 PP
   S: 118  eeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLesftkee 198
           ++++ + +    +++k  kk  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+++L++ft++e
   Q: 463  TTGSLQPAHVPASQRKLIKKVMNVVNTIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYHCNGKetsaqypcLLTEMLAKFTETE 551
           666777777778999*********************************************9998877789999999************* PP
   S: 199  elegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke.. 274
            leg n y c++c++k++           a+k+l+++klP+vL lhLkRf++s + ++reki  +v+f + L+++p+c+++++++ +  
   Q: 552  ALEG-NIYACDQCNSKRRrfsskpvilteAQKQLMVHKLPQVLRLHLKRFRWSGR-NHREKIGVHVSFDQILNMEPYCCRDSTGNLKpd 638
           ***9.77*******9999999*******************************997.8889********************998887777 PP
   S: 275  kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + +YeL+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++ +ev++   ++aY+lfY++
   Q: 639  CFIYELSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNICTVDEVCK---AQAYILFYTQ 700
           99**************************9999********************...********98 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI EEHALKHFQE 60
QRHPVAMEVN ELYVFCYLCD DYVLNDNAMG DLKLLRSTLS AIKSQNYEVT TRSGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAACAAC GCAGCTCGAT TTTCTGATAA CGAATGCTAA CTTGCTTGAT TGCCAAGGGC 60
ACTTTTTACT GCTGAAATAT ACCTGTTCAG CAGAAACCGC TCCGTATCAA CAGCAACCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	68.39	0.00e+00	945.00
IUUC-Apl-003673	Anas platyrhynchos	73.78	0.00e+00	1022.00
IUUC-Aca-004434	Anolis carolinensis	73.91	0.00e+00	1033.00
IUUC-Ame-010986	Astyanax mexicanus	71.45	0.00e+00	959.00
IUUC-Bta-012774	Bos taurus	68.35	0.00e+00	948.00
IUUC-Cfa-020957	Canis familiaris	67.83	0.00e+00	955.00
IUUC-Cin-025587	Ciona intestinalis	48.44	5.00e-112	399.00
IUUC-Csv-025814	Ciona savignyi	42.76	5.00e-146	511.00
IUUC-Dre-027878	Danio rerio	72.54	0.00e+00	939.00
IUUC-Dno-029832	Dasypus novemcinctus	68.35	0.00e+00	950.00
IUUC-Ete-032627	Echinops telfairi	66.48	0.00e+00	925.00
IUUC-Eca-033863	Equus caballus	66.81	0.00e+00	928.00
IUUC-Eeu-035225	Erinaceus europaeus	64.75	0.00e+00	879.00
IUUC-Fca-036288	Felis catus	67.97	0.00e+00	936.00
IUUC-Fal-037207	Ficedula albicollis	72.77	0.00e+00	995.00
IUUC-Gga-040457	Gallus gallus	73.22	0.00e+00	997.00
IUUC-Gac-042371	Gasterosteus aculeatus	69.73	1.00e-165	576.00
IUUC-Lch-050260	Latimeria chalumnae	70.36	0.00e+00	946.00
IUUC-Laf-054491	Loxodonta africana	66.85	0.00e+00	915.00
IUUC-Meu-055971	Macropus eugenii	49.80	9.00e-117	414.00
IUUC-Mga-059523	Meleagris gallopavo	73.36	0.00e+00	1013.00
IUUC-Mmr-060885	Microcebus murinus	69.28	0.00e+00	964.00
IUUC-Mdo-063018	Monodelphis domestica	73.57	0.00e+00	1003.00
IUUC-Mmu-064012	Mus musculus	61.96	0.00e+00	839.00
IUUC-Mpu-066207	Mustela putorius furo	68.58	0.00e+00	961.00
IUUC-Mlu-066929	Myotis lucifugus	65.47	0.00e+00	893.00
IUUC-Ont-071637	Oreochromis niloticus	72.13	0.00e+00	952.00
IUUC-Ocu-074836	Oryctolagus cuniculus	65.56	0.00e+00	910.00
IUUC-Oar-089953	Ovis aries	68.30	0.00e+00	958.00
IUUC-Pma-094293	Petromyzon marinus	63.88	1.00e-73	269.00
IUUC-Pfo-096860	Poecilia formosa	69.13	0.00e+00	912.00
IUUC-Pva-102984	Pteropus vampyrus	67.88	0.00e+00	956.00
IUUC-Rno-106019	Rattus norvegicus	61.84	0.00e+00	867.00
IUUC-Sha-106965	Sarcophilus harrisii	73.04	0.00e+00	998.00
IUUC-Ssc-115299	Sus scrofa	67.69	0.00e+00	954.00
IUUC-Tgu-117160	Taeniopygia guttata	73.13	0.00e+00	1012.00
IUUC-Tru-118156	Takifugu rubripes	69.36	0.00e+00	922.00
IUUC-Tni-119733	Tetraodon nigroviridis	65.67	0.00e+00	924.00
IUUC-Tbe-128084	Tupaia belangeri	65.18	0.00e+00	919.00
IUUC-Ttr-128928	Tursiops truncatus	68.54	0.00e+00	962.00
IUUC-Vpa-130706	Vicugna pacos	67.42	0.00e+00	952.00
IUUC-Xtr-132061	Xenopus tropicalis	71.91	0.00e+00	956.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence