iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.10e-12	47.8	34	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv++ v+g++f+ah++vLaa+Ss+F++ + ++ +    +l+v++ + v  + f+ l++F Yt kl +
   Q: 34   CDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDA---ELTVTLPEeVTVKGFEPLIQFAYTAKLIL 98
           8*****************************777664...579****66*****************987 PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

Protein Sequence
(Fasta)

MSVSESAVFA YESSVHSTNV LLSLNDQRKK DVLCDVTVLV EGQRFRAHRS VLAACSSYFH 60
SRIVGQTDAE LTVTLPEEVT VKGFEPLIQF AYTAKLILSK DNVDEVCRCV EFLSVHNIEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGAGGAA CGGAGCGCAG GGGAGGAGAC GGGCGGCTGT CCGCGCAGAG GGAGTGAGTC 60
ACCTGACCGC CGCTTGCCGC CTGCAGTCGG GCCGCGCCGC GTCTCGGCTC CGGTAAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000210--BTB/POZ_dom
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR011333--SKP1/BTB/POZ
IPR008917--TF_DNA-bd

PROSITE

PS50097--BTB
PS50217--BZIP
PS00036--BZIP_BASIC

Pfam

PF00651--BTB
PF03131--bZIP_Maf

SMART

SM00338--BRLZ
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001205--F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0006302--P:double-strand break repair
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117--P:regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

mmu:12013

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002273	Ailuropoda melanoleuca	77.06	0.00e+00	1068.00
IUUC-Apl-003378	Anas platyrhynchos	63.20	0.00e+00	749.00
IUUC-Aca-004992	Anolis carolinensis	52.96	0.00e+00	645.00
IUUC-Ame-011817	Astyanax mexicanus	34.78	2.00e-76	280.00
IUUC-Bta-012599	Bos taurus	73.66	0.00e+00	1056.00
IUUC-Cja-019778	Callithrix jacchus	79.46	0.00e+00	1131.00
IUUC-Cfa-020459	Canis familiaris	78.27	0.00e+00	1112.00
IUUC-Cpo-021433	Cavia porcellus	75.88	0.00e+00	1078.00
IUUC-Csa-023346	Chlorocebus sabaeus	80.27	0.00e+00	1126.00
IUUC-Cho-024893	Choloepus hoffmanni	76.76	0.00e+00	1102.00
IUUC-Dre-028155	Danio rerio	37.98	7.00e-45	175.00
IUUC-Dno-029607	Dasypus novemcinctus	77.81	0.00e+00	1107.00
IUUC-Dor-031026	Dipodomys ordii	56.62	1.00e-127	450.00
IUUC-Ete-032304	Echinops telfairi	69.00	0.00e+00	912.00
IUUC-Eca-033379	Equus caballus	75.48	0.00e+00	875.00
IUUC-Eeu-035358	Erinaceus europaeus	76.21	0.00e+00	863.00
IUUC-Fca-035499	Felis catus	78.67	0.00e+00	1126.00
IUUC-Fal-037171	Ficedula albicollis	62.00	0.00e+00	699.00
IUUC-Gga-041169	Gallus gallus	59.06	0.00e+00	781.00
IUUC-Ggo-044485	Gorilla gorilla	79.86	0.00e+00	1140.00
IUUC-Hsa-046202	Homo sapiens	80.27	0.00e+00	1123.00
IUUC-Itr-047970	Ictidomys tridecemlineatus	79.62	0.00e+00	1145.00
IUUC-Loc-052298	Lepisosteus oculatus	45.58	1.00e-57	217.00
IUUC-Laf-054320	Loxodonta africana	75.54	0.00e+00	876.00
IUUC-Mcc-055644	Macaca mulatta	80.54	0.00e+00	1128.00
IUUC-Mga-059196	Meleagris gallopavo	58.74	0.00e+00	769.00
IUUC-Mmr-061053	Microcebus murinus	80.70	0.00e+00	1154.00
IUUC-Mdo-062091	Monodelphis domestica	58.81	0.00e+00	718.00
IUUC-Mpu-065768	Mustela putorius furo	77.30	0.00e+00	1082.00
IUUC-Mlu-067451	Myotis lucifugus	71.79	0.00e+00	959.00
IUUC-Nle-069507	Nomascus leucogenys	79.86	0.00e+00	1142.00
IUUC-Oan-073692	Ornithorhynchus anatinus	67.96	2.00e-97	350.00
IUUC-Ocu-074850	Oryctolagus cuniculus	81.73	0.00e+00	1046.00
IUUC-Oga-088762	Otolemur garnettii	78.98	0.00e+00	1125.00
IUUC-Oar-089511	Ovis aries	77.86	0.00e+00	990.00
IUUC-Ptr-091232	Pan troglodytes	80.00	0.00e+00	1156.00
IUUC-Pan-091803	Papio anubis	80.54	0.00e+00	1129.00
IUUC-Pab-098303	Pongo abelii	80.00	0.00e+00	1142.00
IUUC-Pca-100147	Procavia capensis	68.37	0.00e+00	647.00
IUUC-Pva-102920	Pteropus vampyrus	78.39	0.00e+00	1119.00
IUUC-Rno-105893	Rattus norvegicus	92.42	0.00e+00	1308.00
IUUC-Sha-107059	Sarcophilus harrisii	64.68	0.00e+00	837.00
IUUC-Sar-113133	Sorex araneus	71.65	5.00e-150	525.00
IUUC-Ssc-115328	Sus scrofa	77.01	0.00e+00	1060.00
IUUC-Tgu-116625	Taeniopygia guttata	61.38	0.00e+00	808.00
IUUC-Tru-118149	Takifugu rubripes	39.63	4.00e-45	176.00
IUUC-Tni-120068	Tetraodon nigroviridis	33.73	3.00e-72	266.00
IUUC-Ttr-128805	Tursiops truncatus	77.04	0.00e+00	778.00
IUUC-Xtr-132494	Xenopus tropicalis	45.91	2.00e-163	569.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence