iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.06	0.00e+00	631.00	IUUC-Hsa-046597

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MESGSRPSLG QVILLGTSSM VTAVLYSIYR QKAQVAQELK GAKKIHLGED LKAILSEAPG 60
KCVPYAVIEG AVRSVKETLN SQFVENCKGV IQRLTLQEHK MVWNRTTHLW NDYSKIIHQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCATCAACGG GCGCCCGGCC TACGGTTTCC GGGAAGGGCT GCGCAGCTGC GTAGGGGTCG 60
CGGGTGATTT CGAGGCAGCT GGCGCGGCTC GGGGTCGCCA TGGAGAGCGG ATCGCGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR022170--GIDE
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

Pfam

PF12483--GIDE

Gene Ontology

GO:0030424--C:axon
GO:0031307--C:integral component of mitochondrial outer membrane
GO:0043025--C:neuronal cell body
GO:0005777--C:peroxisome
GO:0004871--F:signal transducer activity
GO:0019789--F:SUMO transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257--P:activation of JUN kinase activity
GO:0071360--P:cellular response to exogenous dsRNA
GO:0000266--P:mitochondrial fission
GO:0051646--P:mitochondrion localization
GO:0030308--P:negative regulation of cell growth
GO:0071650--P:negative regulation of chemokine (C-C motif) ligand 5 production
GO:0050689--P:negative regulation of defense response to virus by host
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0060339--P:negative regulation of type I interferon-mediated signaling pathway
GO:1903861--P:positive regulation of dendrite extension
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090141--P:positive regulation of mitochondrial fission
GO:1904925--P:positive regulation of mitophagy in response to mitochondrial depolarization
GO:0033235--P:positive regulation of protein sumoylation
GO:0031648--P:protein destabilization
GO:0050821--P:protein stabilization
GO:0051881--P:regulation of mitochondrial membrane potential
GO:1901028--P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

KEGG

rno:298576

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000342	Aegilops tauschii	25.90	3.00e-12	67.40
IUUC-Aml-002287	Ailuropoda melanoleuca	90.06	0.00e+00	635.00
IUUC-Atr-002698	Amborella trichopoda	23.46	1.00e-07	50.80
IUUC-Aca-005039	Anolis carolinensis	38.84	2.00e-64	239.00
IUUC-Aly-006181	Arabidopsis lyrata	28.94	8.00e-21	94.40
IUUC-Ath-007438	Arabidopsis thaliana	29.23	1.00e-21	97.40
IUUC-Ame-010671	Astyanax mexicanus	61.93	3.00e-127	447.00
IUUC-Bta-012407	Bos taurus	78.75	3.00e-161	560.00
IUUC-Bdi-014735	Brachypodium distachyon	25.44	6.00e-17	81.60
IUUC-Bol-015493	Brassica oleracea	27.22	1.00e-20	93.60
IUUC-Bra-016933	Brassica rapa	26.69	9.00e-19	87.40
IUUC-Cja-019709	Callithrix jacchus	90.34	1.00e-170	591.00
IUUC-Cfa-020818	Canis familiaris	90.34	0.00e+00	647.00
IUUC-Cpo-022490	Cavia porcellus	90.62	0.00e+00	627.00
IUUC-Csa-023259	Chlorocebus sabaeus	90.06	0.00e+00	643.00
IUUC-Cho-024730	Choloepus hoffmanni	89.49	0.00e+00	638.00
IUUC-Cin-025301	Ciona intestinalis	31.53	8.00e-46	177.00
IUUC-Dre-028644	Danio rerio	61.93	8.00e-129	452.00
IUUC-Dno-028925	Dasypus novemcinctus	89.20	0.00e+00	641.00
IUUC-Dor-030692	Dipodomys ordii	92.90	0.00e+00	647.00
IUUC-Dme-031761	Drosophila melanogaster	30.95	3.00e-31	129.00
IUUC-Ete-032329	Echinops telfairi	80.11	6.00e-153	533.00
IUUC-Eca-034008	Equus caballus	86.36	1.00e-179	622.00
IUUC-Eeu-034895	Erinaceus europaeus	75.32	8.00e-123	432.00
IUUC-Fca-036104	Felis catus	90.06	0.00e+00	641.00
IUUC-Fal-036900	Ficedula albicollis	71.14	3.00e-139	487.00
IUUC-Gmo-039049	Gadus morhua	58.24	2.00e-106	379.00
IUUC-Gga-040254	Gallus gallus	68.47	2.00e-138	484.00
IUUC-Gac-042277	Gasterosteus aculeatus	59.94	4.00e-132	464.00
IUUC-Gma-043979	Glycine max	26.28	1.00e-18	87.00
IUUC-Ggo-045509	Gorilla gorilla	90.06	0.00e+00	643.00
IUUC-Hsa-046597	Homo sapiens	90.06	0.00e+00	643.00
IUUC-Hvu-047335	Hordeum vulgare	25.83	2.00e-17	82.40
IUUC-Itr-048691	Ictidomys tridecemlineatus	92.61	0.00e+00	644.00
IUUC-Lch-050344	Latimeria chalumnae	66.48	9.00e-142	496.00
IUUC-Lpe-051343	Leersia perrieri	27.35	2.00e-12	66.60
IUUC-Loc-052376	Lepisosteus oculatus	66.19	3.00e-144	504.00
IUUC-Laf-054414	Loxodonta africana	89.20	0.00e+00	640.00
IUUC-Mcc-054604	Macaca mulatta	89.77	0.00e+00	642.00
IUUC-Meu-056087	Macropus eugenii	82.10	2.00e-165	575.00
IUUC-Mtr-057779	Medicago truncatula	26.02	1.00e-18	87.40
IUUC-Mga-060188	Meleagris gallopavo	70.51	1.00e-137	482.00
IUUC-Mmr-060704	Microcebus murinus	90.91	0.00e+00	651.00
IUUC-Mdo-062842	Monodelphis domestica	81.53	2.00e-161	561.00
IUUC-Mmu-064324	Mus musculus	96.88	0.00e+00	660.00
IUUC-Mpu-065940	Mustela putorius furo	88.64	1.00e-177	615.00
IUUC-Mlu-067028	Myotis lucifugus	90.91	0.00e+00	653.00
IUUC-Nle-069254	Nomascus leucogenys	83.62	6.00e-170	589.00
IUUC-Opr-070827	Ochotona princeps	86.36	2.00e-178	617.00
IUUC-Ont-072008	Oreochromis niloticus	61.08	1.00e-134	472.00
IUUC-Oan-072935	Ornithorhynchus anatinus	78.98	9.00e-164	569.00
IUUC-Ocu-074526	Oryctolagus cuniculus	90.34	0.00e+00	625.00
IUUC-Oba-075954	Oryza barthii	27.35	2.00e-12	66.20
IUUC-Obr-076592	Oryza brachyantha	25.73	1.00e-19	90.50
IUUC-Ogl-077732	Oryza glaberrima	25.73	1.00e-19	90.50
IUUC-Ogu-078565	Oryza glumaepatula	27.35	2.00e-12	66.60
IUUC-Oin-080188	Oryza indica	25.73	1.00e-19	90.50
IUUC-Olo-080705	Oryza longistaminata	25.63	5.00e-10	59.30
IUUC-Ome-081154	Oryza meridionalis	27.35	1.00e-12	67.40
IUUC-Oni-082201	Oryza nivara	27.35	2.00e-12	66.20
IUUC-Opu-083497	Oryza punctata	27.57	1.00e-12	67.00
IUUC-Oru-084332	Oryza rufipogon	27.35	2.00e-12	66.20
IUUC-Osa-086059	Oryza sativa	27.35	6.00e-13	67.80
IUUC-Ola-087288	Oryzias latipes	56.82	3.00e-123	434.00
IUUC-Oga-088402	Otolemur garnettii	90.62	0.00e+00	648.00
IUUC-Oar-089851	Ovis aries	90.74	1.00e-86	311.00
IUUC-Ptr-091226	Pan troglodytes	89.77	0.00e+00	642.00
IUUC-Pan-092575	Papio anubis	89.49	0.00e+00	641.00
IUUC-Psi-094062	Pelodiscus sinensis	76.14	2.00e-158	551.00
IUUC-Pma-094501	Petromyzon marinus	35.69	2.00e-44	172.00
IUUC-Ppa-095285	Physcomitrella patens	25.23	8.00e-13	67.80
IUUC-Pfo-096146	Poecilia formosa	57.39	4.00e-120	424.00
IUUC-Pab-098524	Pongo abelii	89.77	0.00e+00	642.00
IUUC-Pop-099864	Populus trichocarpa	27.57	2.00e-17	83.20
IUUC-Pca-100314	Procavia capensis	89.49	0.00e+00	639.00
IUUC-Ppe-101663	Prunus persica	26.18	2.00e-17	82.80
IUUC-Pva-102947	Pteropus vampyrus	89.49	0.00e+00	639.00
IUUC-Sha-107500	Sarcophilus harrisii	67.30	5.00e-114	404.00
IUUC-Smo-109194	Selaginella moellendorffii	26.36	2.00e-18	86.70
IUUC-Sit-109922	Setaria italica	25.44	1.00e-18	87.00
IUUC-Sly-111826	Solanum lycopersicum	26.89	4.00e-19	89.00
IUUC-Stu-112907	Solanum tuberosum	26.51	3.00e-18	85.90
IUUC-Sar-113522	Sorex araneus	87.18	3.00e-156	543.00
IUUC-Sbi-114536	Sorghum bicolor	25.73	1.00e-20	94.00
IUUC-Ssc-115445	Sus scrofa	91.19	0.00e+00	628.00
IUUC-Tgu-116551	Taeniopygia guttata	71.31	7.00e-138	483.00
IUUC-Tru-118407	Takifugu rubripes	57.10	7.00e-116	410.00
IUUC-Tsy-118794	Tarsius syrichta	88.35	3.00e-180	624.00
IUUC-Tni-120128	Tetraodon nigroviridis	63.98	4.00e-93	333.00
IUUC-Tca-121508	Theobroma cacao	26.38	3.00e-20	92.40
IUUC-Tae-125185	Triticum aestivum	26.76	5.00e-21	95.10
IUUC-Tur-126470	Triticum urartu	26.47	7.00e-21	94.70
IUUC-Tbe-127432	Tupaia belangeri	89.77	1.00e-178	618.00
IUUC-Ttr-128573	Tursiops truncatus	88.35	0.00e+00	632.00
IUUC-Vpa-130583	Vicugna pacos	88.78	1.00e-162	565.00
IUUC-Vvi-131710	Vitis vinifera	27.44	2.00e-15	76.60
IUUC-Xtr-132009	Xenopus tropicalis	63.84	2.00e-132	464.00
IUUC-Xma-134121	Xiphophorus maculatus	56.53	6.00e-124	436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence