iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028518

Ensembl Protein ID

ENSDARP00000040554.5

UniProt Accession

Q66I04; Q66I04_DANRE

Genbank Protein ID

AAH81601.1

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

CU571330

Gene Name

lyn; zgc:92124

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000031715.5	ENSDART00000040555.5	ENSDARP00000040554.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-16	61.1	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++ v +ly+yea + d+L +kkG+++++i   e+ ++W+k+ + ++ k+G++P+n+v++++
   Q: 62   KEKIVVALYPYEAIHADDLGFKKGEKLKII---EEHGEWWKARSLTTRKEGFIPSNYVAEAD 120
           56889*************************...999**********************9986 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MGCKKSKLDG DQNGCVLEPV NKEHPVRTDQ TYVRDPTSYK PPITSQNAGL LPGQVFQKME 60
EKEKIVVALY PYEAIHADDL GFKKGEKLKI IEEHGEWWKA RSLTTRKEGF IPSNYVAEAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTGGTT CCTCATTCTG CGTTTGTGTG CGTGTGTGTG GCGCTTCAAT GAGAGTCAGA 60
GAGCGCGCAC TCGACGGTCA TTCCTCTCAG AAACAAGTCC CTTTAAATGC GAGTTAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007417--P:central nervous system development
GO:0097028--P:dendritic cell differentiation
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0070667--P:negative regulation of mast cell proliferation
GO:0031175--P:neuron projection development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0002576--P:platelet degranulation
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0002902--P:regulation of B cell apoptotic process
GO:0050855--P:regulation of B cell receptor signaling pathway
GO:0043304--P:regulation of mast cell degranulation
GO:0090022--P:regulation of neutrophil chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0009611--P:response to wounding
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

dre:447804

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	76.46	0.00e+00	811.00
IUUC-Apl-004139	Anas platyrhynchos	77.46	0.00e+00	818.00
IUUC-Aca-004333	Anolis carolinensis	78.21	0.00e+00	830.00
IUUC-Ame-011257	Astyanax mexicanus	86.02	0.00e+00	923.00
IUUC-Bta-013257	Bos taurus	76.16	0.00e+00	813.00
IUUC-Cja-018827	Callithrix jacchus	76.36	0.00e+00	809.00
IUUC-Cfa-020816	Canis familiaris	76.31	0.00e+00	811.00
IUUC-Cpo-021423	Cavia porcellus	76.85	0.00e+00	823.00
IUUC-Csa-024244	Chlorocebus sabaeus	76.16	0.00e+00	807.00
IUUC-Dno-029322	Dasypus novemcinctus	76.89	0.00e+00	815.00
IUUC-Dor-030706	Dipodomys ordii	73.61	0.00e+00	723.00
IUUC-Eca-034193	Equus caballus	76.46	0.00e+00	818.00
IUUC-Fal-037273	Ficedula albicollis	78.25	0.00e+00	826.00
IUUC-Gmo-039677	Gadus morhua	82.10	0.00e+00	786.00
IUUC-Gga-040417	Gallus gallus	76.95	0.00e+00	817.00
IUUC-Gac-042490	Gasterosteus aculeatus	79.57	0.00e+00	857.00
IUUC-Ggo-045096	Gorilla gorilla	75.97	0.00e+00	807.00
IUUC-Hsa-046214	Homo sapiens	75.97	0.00e+00	807.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	76.65	0.00e+00	816.00
IUUC-Lch-049991	Latimeria chalumnae	78.65	0.00e+00	818.00
IUUC-Loc-052309	Lepisosteus oculatus	85.49	0.00e+00	913.00
IUUC-Laf-053568	Loxodonta africana	76.55	0.00e+00	817.00
IUUC-Mcc-054849	Macaca mulatta	76.16	0.00e+00	807.00
IUUC-Meu-056170	Macropus eugenii	68.87	0.00e+00	660.00
IUUC-Mmr-061519	Microcebus murinus	76.26	0.00e+00	815.00
IUUC-Mdo-062090	Monodelphis domestica	73.56	0.00e+00	763.00
IUUC-Mmu-063760	Mus musculus	76.46	0.00e+00	814.00
IUUC-Mpu-065677	Mustela putorius furo	76.65	0.00e+00	817.00
IUUC-Mlu-067386	Myotis lucifugus	76.74	0.00e+00	815.00
IUUC-Nle-069742	Nomascus leucogenys	76.16	0.00e+00	808.00
IUUC-Ont-071537	Oreochromis niloticus	81.71	0.00e+00	885.00
IUUC-Oan-073193	Ornithorhynchus anatinus	76.94	0.00e+00	825.00
IUUC-Ocu-074501	Oryctolagus cuniculus	76.74	0.00e+00	817.00
IUUC-Ola-086726	Oryzias latipes	80.35	0.00e+00	874.00
IUUC-Oga-088069	Otolemur garnettii	75.87	0.00e+00	806.00
IUUC-Oar-090091	Ovis aries	76.16	0.00e+00	812.00
IUUC-Ptr-091409	Pan troglodytes	75.97	0.00e+00	807.00
IUUC-Pan-092268	Papio anubis	76.16	0.00e+00	808.00
IUUC-Psi-093685	Pelodiscus sinensis	76.88	0.00e+00	817.00
IUUC-Pfo-096217	Poecilia formosa	80.70	0.00e+00	874.00
IUUC-Pab-098601	Pongo abelii	76.16	0.00e+00	808.00
IUUC-Rno-105557	Rattus norvegicus	76.07	0.00e+00	811.00
IUUC-Sha-106643	Sarcophilus harrisii	76.25	0.00e+00	809.00
IUUC-Ssc-116317	Sus scrofa	71.68	0.00e+00	747.00
IUUC-Tgu-116865	Taeniopygia guttata	78.25	0.00e+00	828.00
IUUC-Tru-118284	Takifugu rubripes	79.57	0.00e+00	851.00
IUUC-Tsy-119440	Tarsius syrichta	74.22	0.00e+00	785.00
IUUC-Tni-120005	Tetraodon nigroviridis	78.60	0.00e+00	847.00
IUUC-Ttr-128481	Tursiops truncatus	70.82	0.00e+00	676.00
IUUC-Xtr-131907	Xenopus tropicalis	69.81	0.00e+00	724.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence