iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045109

UUCD1 version

UUC-GoG-01099

Ensembl Protein ID

ENSGGOP00000024481.1

UniProt Accession

G3S8R8; G3S8R8_GORGO

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000025937.1	ENSGGOT00000025366.1	ENSGGOP00000024481.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-90	303.7	180	522

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 180  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 264
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k                  s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 265  DAHEFLIAILDVLHRHSKD----------------DSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 337
           *****************22................1223456899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 338  CATFDSqnperadstvsrddhipgipSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 424
           98776689999*******************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 425  INTFISFPLELDMTPFLASTKESRMKegqpptdcvpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 511
           *****************99665555578888888888**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 512  -SEGYLLFYHKQ 522
           .********985 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

LDGSGDPGGL GDWLLEGEFG QGPTGCSHVE SFKVGKNWQK NLRLIYQRFV WSGTPETRKR 60
KAKSCICHVC STHMNRLHSC LSCVFFGCFT EKHIHKHAET KQHHLAVDLY HGVIYCFMCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGACGGGT CGGGGGATCC TGGCGGCTTG GGGGACTGGT TGCTGGAGGG CGAGTTTGGT 60
CAGGGCCCCA CAGGCTGCTC TCATGTGGAG AGCTTTAAAG TAGGTAAGAA CTGGCAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	91.25	0.00e+00	959.00
IUUC-Csa-023824	Chlorocebus sabaeus	96.01	0.00e+00	1006.00
IUUC-Eca-033872	Equus caballus	92.23	0.00e+00	966.00
IUUC-Fca-035534	Felis catus	91.14	0.00e+00	979.00
IUUC-Hsa-045765	Homo sapiens	96.96	0.00e+00	1019.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	92.23	0.00e+00	934.00
IUUC-Mcc-055420	Macaca mulatta	95.93	0.00e+00	1036.00
IUUC-Mmr-061690	Microcebus murinus	92.50	0.00e+00	992.00
IUUC-Mmu-063435	Mus musculus	76.65	0.00e+00	800.00
IUUC-Mac-065419	Musa acuminata	33.87	5.00e-73	268.00
IUUC-Mpu-065679	Mustela putorius furo	90.89	0.00e+00	954.00
IUUC-Mlu-067084	Myotis lucifugus	89.67	0.00e+00	972.00
IUUC-Nle-069859	Nomascus leucogenys	96.77	0.00e+00	1018.00
IUUC-Ocu-074365	Oryctolagus cuniculus	90.72	0.00e+00	950.00
IUUC-Ptr-091479	Pan troglodytes	96.77	0.00e+00	1020.00
IUUC-Pan-091707	Papio anubis	95.82	0.00e+00	1002.00
IUUC-Pab-097894	Pongo abelii	96.79	0.00e+00	1022.00
IUUC-Pgr-103657	Puccinia graminis	29.25	6.00e-38	152.00
IUUC-Rno-105644	Rattus norvegicus	76.85	0.00e+00	809.00
IUUC-Sar-113426	Sorex araneus	79.85	0.00e+00	807.00
IUUC-Ssc-115500	Sus scrofa	89.77	0.00e+00	940.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence