iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046429

UUCD1 version

UUC-HoS-00194

Ensembl Protein ID

ENSP00000309141.5

UniProt Accession

Q86UD3; A8K264; B9EJE7; MARH3_HUMAN

Genbank Protein ID

BAF82818.1; EAW62412.1; EAW62413.1; AAH47569.1; AAI46949.1; AAI46965.1

Protein Name

E3 ubiquitin-protein ligase MARCH3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING finger protein 173; RING-type E3 ubiquitin transferase MARCH3

Genbank Nucleotide ID

AK290129; AC004507; CH471062; BC047569; BC146948; BC146964

Gene Name

MARCH3; RNF173

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000173926.5	ENST00000308660.5	ENSP00000309141.5
ENSG00000173926.5	ENST00000515241.1	ENSP00000421979.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17604280

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.003	19.7	71	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHv.....fhadClqkwpglknssskefrCPlC 45
           C iC+e  +++ l+ pC  +     +h++Cl++w     sss++ +C lC
   Q: 71   CRICHEGSSQEDLLSPCECTgtlgtIHRSCLEHW----LSSSNTSYCELC 116
           ******99777889***98788898*********....88********** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTTSRCSHLP EVLPDCTSSA APVVKTVEDC GSLVNGQPQY VMQVSAKDGQ LLSTVVRTLA 60
TQSPFNDRPM CRICHEGSSQ EDLLSPCECT GTLGTIHRSC LEHWLSSSNT SYCELCHFRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTCCCGCA GCGCCCGCCG GCAGCCACGG CACTTCGCAA TAACCAACTT CCCCGCCGCC 60
GGCGCGTCCC GCCAGCCTGC CCTCGGCCGC AGGCGACTGG ACGGCGGTTA CGGGGCGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005764--C:lysosome
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016567--P:protein ubiquitination

KEGG

hsa:115123

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000798	Aegilops tauschii	38.89	1.00e-08	54.30
IUUC-Aml-001957	Ailuropoda melanoleuca	98.81	4.00e-148	516.00
IUUC-Aca-005012	Anolis carolinensis	96.47	4.00e-144	503.00
IUUC-Aly-006064	Arabidopsis lyrata	38.89	2.00e-08	52.80
IUUC-Bta-012331	Bos taurus	98.02	1.00e-147	515.00
IUUC-Bdi-014827	Brachypodium distachyon	36.07	9.00e-09	54.30
IUUC-Bol-016602	Brassica oleracea	34.67	1.00e-09	56.60
IUUC-Bra-016852	Brassica rapa	36.51	1.00e-09	57.00
IUUC-Cel-018164	Caenorhabditis elegans	37.17	1.00e-18	87.80
IUUC-Cja-019689	Callithrix jacchus	99.21	1.00e-148	518.00
IUUC-Cfa-020911	Canis familiaris	98.81	4.00e-148	516.00
IUUC-Cpo-022306	Cavia porcellus	97.23	4.00e-144	503.00
IUUC-Cre-022957	Chlamydomonas reinhardtii	37.80	4.00e-08	52.40
IUUC-Csa-024010	Chlorocebus sabaeus	99.21	4.00e-148	516.00
IUUC-Cho-024645	Choloepus hoffmanni	97.89	2.00e-110	390.00
IUUC-Dno-029999	Dasypus novemcinctus	98.42	3.00e-148	517.00
IUUC-Dor-030860	Dipodomys ordii	98.81	1.00e-148	518.00
IUUC-Ete-032571	Echinops telfairi	97.63	2.00e-146	511.00
IUUC-Eca-034097	Equus caballus	98.81	2.00e-148	517.00
IUUC-Eeu-034645	Erinaceus europaeus	99.24	2.00e-74	271.00
IUUC-Fca-036126	Felis catus	97.63	2.00e-146	511.00
IUUC-Fal-036875	Ficedula albicollis	81.82	2.00e-119	421.00
IUUC-Gga-041200	Gallus gallus	94.88	2.00e-120	425.00
IUUC-Gma-043460	Glycine max	35.82	6.00e-10	58.20
IUUC-Ggo-044825	Gorilla gorilla	100.00	1.00e-149	522.00
IUUC-Hvu-047111	Hordeum vulgare	38.89	9.00e-09	54.30
IUUC-Itr-048087	Ictidomys tridecemlineatus	99.21	1.00e-148	518.00
IUUC-Lch-049917	Latimeria chalumnae	91.30	7.00e-137	479.00
IUUC-Loc-052071	Lepisosteus oculatus	88.93	1.00e-132	465.00
IUUC-Laf-054385	Loxodonta africana	98.02	2.00e-147	514.00
IUUC-Mcc-054854	Macaca mulatta	99.60	7.00e-149	519.00
IUUC-Mtr-057809	Medicago truncatula	35.82	7.00e-10	57.80
IUUC-Mmr-061764	Microcebus murinus	97.83	1.00e-105	375.00
IUUC-Mmu-063185	Mus musculus	99.21	1.00e-148	518.00
IUUC-Mac-064882	Musa acuminata	38.00	1.00e-08	53.90
IUUC-Mpu-066646	Mustela putorius furo	98.81	4.00e-148	516.00
IUUC-Mlu-067494	Myotis lucifugus	97.63	4.00e-147	513.00
IUUC-Nle-069945	Nomascus leucogenys	99.60	7.00e-149	519.00
IUUC-Opr-070431	Ochotona princeps	98.02	4.00e-147	513.00
IUUC-Ocu-074430	Oryctolagus cuniculus	98.02	3.00e-147	514.00
IUUC-Oba-075948	Oryza barthii	32.14	3.00e-09	55.80
IUUC-Ogl-077439	Oryza glaberrima	32.14	3.00e-09	55.80
IUUC-Ogu-078523	Oryza glumaepatula	31.11	2.00e-09	55.80
IUUC-Olo-080950	Oryza longistaminata	35.29	8.00e-09	54.30
IUUC-Ome-081221	Oryza meridionalis	32.14	2.00e-09	56.20
IUUC-Oni-082096	Oryza nivara	32.14	3.00e-09	55.80
IUUC-Opu-083949	Oryza punctata	32.14	2.00e-09	56.20
IUUC-Oru-085237	Oryza rufipogon	32.14	3.00e-09	55.80
IUUC-Osa-085964	Oryza sativa	32.14	3.00e-09	55.80
IUUC-Oga-088072	Otolemur garnettii	98.42	1.00e-147	515.00
IUUC-Oar-089761	Ovis aries	98.42	4.00e-148	516.00
IUUC-Ptr-090839	Pan troglodytes	99.60	2.00e-149	520.00
IUUC-Pan-092795	Papio anubis	99.60	7.00e-149	519.00
IUUC-Psi-093674	Pelodiscus sinensis	97.23	1.00e-146	511.00
IUUC-Pma-094464	Petromyzon marinus	69.07	1.00e-75	275.00
IUUC-Pab-098050	Pongo abelii	99.60	7.00e-149	519.00
IUUC-Pop-099863	Populus trichocarpa	35.21	2.00e-09	56.60
IUUC-Pca-100548	Procavia capensis	92.49	3.00e-134	470.00
IUUC-Pva-103060	Pteropus vampyrus	98.81	4.00e-148	516.00
IUUC-Rno-104870	Rattus norvegicus	98.81	1.00e-148	518.00
IUUC-Sit-110468	Setaria italica	37.70	3.00e-09	55.80
IUUC-Sly-110996	Solanum lycopersicum	40.00	1.00e-11	63.50
IUUC-Stu-112782	Solanum tuberosum	40.00	2.00e-11	63.20
IUUC-Sar-113720	Sorex araneus	98.02	9.00e-148	515.00
IUUC-Sbi-114312	Sorghum bicolor	31.25	1.00e-09	57.00
IUUC-Ssc-116322	Sus scrofa	98.42	1.00e-147	515.00
IUUC-Tsy-119057	Tarsius syrichta	99.21	1.00e-148	518.00
IUUC-Tca-121215	Theobroma cacao	39.68	7.00e-10	57.80
IUUC-Tae-124189	Triticum aestivum	32.93	2.00e-09	56.20
IUUC-Tur-126784	Triticum urartu	39.44	8.00e-09	55.10
IUUC-Tbe-128101	Tupaia belangeri	98.81	4.00e-148	516.00
IUUC-Ttr-128776	Tursiops truncatus	99.21	7.00e-149	519.00
IUUC-Vpa-130717	Vicugna pacos	96.84	1.00e-107	381.00
IUUC-Vvi-131510	Vitis vinifera	42.59	4.00e-09	56.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence